📇 Rhumatologue · MARTRES TOLOSANE · (31) · Libéral

MME TIPHAINE LEDRUE

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15 articles scientifiques publiés — formation continue solide
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Rhumatologue

📍 MARTRES TOLOSANE (31)LibéralRPPS 10002079076

✨ Génération du profil synthétique IA en cours…

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Top publications · les plus citées

Consumption of Bifidobacterium lactis Bi-07 by healthy elderly adults enhances phagocytic activity of monocytes and granulocytes

Journal of nutritional science · 2013

📚 37 citations🎯 RCR 1.31🔓 Open Access📄 PDF gratuit ↗

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AbstractElderly adults have alterations in their gut microbiota and immune functions that are associated with higher susceptibility to infections and metabolic disorders. Probiotics and prebiotics, and their synbiotic combinations are food supplements that have been shown to improve both gut and immune function. The objective of this randomised, double-blind, placebo-controlled, cross-over human clinical trial was to study immune function and the gut microbiota in healthy elderly adults. Volunteers (n37) consumed prebiotic galacto-oligosaccharides (GOS; 8 g/d), probioticBifidobacterium lactisBi-07 (Bi-07; 109colony-forming units/d), their combination (Bi-07 + GOS) and maltodextrin control (8 g/d) in four 3-week periods separated by 4-week wash-out periods. Immune function was analysed by determining the phagocytic and oxidative burst activity of monocytes and granulocytes, whole-blood response to lipopolysaccharide, plasma chemokine concentrations and salivary IgA levels. Gut microbiota composition and faecal SCFA content were determined using 16S ribosomal RNA fluorescencein situhybridisation and HPLC, respectively. Primary statistical analyses indicated the presence of carry-over effects and thus measurements from only the first supplementation period were considered valid. Subsequent statistical analysis showed that consumption of Bi-07 improved the phagocytic activity of monocytes (P < 0·001) and granulocytes (P = 0·02). Other parameters were unchanged. We have for the first time shown that the probiotic Bi-07 may provide health benefits to elderly individuals by improving the phagocytic activity of monocytes and granulocytes. The present results also suggest that in the elderly, the effects of some probiotics and prebiotics may last longer than in adults.

Risk-stratification management of febrile neutropenia in pediatric hematology-oncology patients: Results of a French nationwide survey

Pediatric blood & cancer · 2016

📚 17 citations

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AbstractBackgroundIn 2012, new international guidelines for children with chemotherapy‐induced febrile neutropenia (FN) were issued, recommending reduced‐intensity management strategy based on stratification of infectious risks. Some studies have highlighted practice disparities in different countries and within the same country. Our aim was to assess the current management strategies for the treatment of chemotherapy‐induced FN in children in France.ProcedureThis survey of all French pediatric oncology‐hematology reference centers (n = 30) in late 2012 and early 2013 sent a standardized questionnaire to each center inquiring about their definition of an FN episode, its initial empiric treatment and ongoing management, use of management stratified by risk, and any criteria used for the risk assessment. Each center's management protocol was also analyzed.ResultsAll French reference centers participated in this survey, completing 88% of the questionnaire items. Definitions of both fever and neutropenia varied between centers. Ten centers used a risk‐stratification strategy for initial management. In all, 42 probabilistic first‐line antibiotic treatments were identified. After 48 hr of apyrexia, 17 units applied different forms of step‐down therapy.ConclusionsMost French centers already offered some form of reduced‐intensity or step‐down therapy, although they differed substantially in their management of FN episodes. Risk stratification with validated tools is essential to facilitate the implementation of the international recommendations, which would ultimately help to standardize practices in France.

Pediatric systemic lupus erythematosus with lupus anticoagulant hypoprothrombinemia syndrome-A case series with review of literature

Lupus · 2021

📚 15 citations🎯 RCR 1.58

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Introduction Lupus anticoagulant hypoprothrombinemia syndrome (LAHPS) is a rare phenomenon that leads to concomitant thrombosis and hemorrhage in children with SLE. LAHPS in pediatric SLE (pSLE) has a protracted course requiring long-term immunosuppressive therapy. Due to the rarity of this syndrome and paucity of reported cases, there is lack of standardized management. We herewith report 5 children with pSLE with LAHPS. Methodology: We retrospectively reviewed clinical features, laboratory features, treatment and outcome for 5 children with lupus anticoagulant hypoprothrombinemia syndrome with SLE and a review of literature of similar cases published. Results Mean age of presentation was 10.2 ± 2.38 years (mean ± SD) and female to male ratio was 4:1. All children presented with mild to severe bleeding manifestations like gum bleed, epistaxis, hematuria, menorrhagia and subarachnoid bleed. Coagulation profile revealed prolonged PT and aPTT, with low prothrombin levels and positive Lupus anticoagulant in all children. Mixing studies were characteristic in these children. On comparing laboratory parameters majority had low C3, C4 levels, ANA and anti-DsDNA antibody positivity and three children had anticardiolipin positivity. One child had lupus nephritis along with LAHPS at presentation. All responded well to steroids and supportive measures. Conclusion High index of suspicion is needed when child with lupus presents with bleeding manifestations for early diagnosis and treatment.

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MME TIPHAINE LEDRUE

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Top publications · les plus citées

Publications scientifiques (15) — classées par pathologie

Case report / série3

Pédiatrie3

Anti-TNF2

Gériatrie2

Lupus2

Revue générale2

csDMARDs1

Épidémiologie & registres1

Transversal1

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