📇 Rhumatologue · ST LEGER DU BOURG DENIS · (76) · Libéral

MME MANUELA LECONTE-ANDRIES

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Auteur de référence en rhumatologie
50 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
119.2 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 ST LEGER DU BOURG DENIS (76)LibéralRPPS 10001917045

✨ Génération du profil synthétique IA en cours…

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CABINET DU DR MANUELA LECONTE-ANDRIES
CENTRE COMMERCIAL DE L AUBETTE ROUTE DE LYONS LA FORET, 76160 ST LEGER DU BOURG DENIS
☎ 0232830303Activité de soin et de pharmacie

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Top publications · les plus citées

Multiple Effects of Ascorbic Acid against Chronic Diseases: Updated Evidence from Preclinical and Clinical Studies

Antioxidants (Basel, Switzerland) · 2020

📚 57 citations🎯 RCR 3.77Top 12% NIH🔓 Open Access📄 PDF gratuit ↗

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Severe disease commonly manifests as a systemic inflammatory process. Inflammation is associated withthe enhanced production of reactive oxygen and nitrogen species and with a marked reduction in the plasma concentrations of protective antioxidant molecules. This imbalance gives rise to oxidative stress, which is greater in patients with more severe conditions such as sepsis, cancer, cardiovascular disease, acute respiratory distress syndrome, and burns. In these patients, oxidative stress can trigger cell, tissue, and organ damage, thus increasing morbidity and mortality. Ascorbic acid (ASC) is a key nutrient thatserves as an antioxidant and a cofactor for numerous enzymatic reactions. However, humans, unlike most mammals, are unable to synthesize it. Consequently, ASC must be obtained through dietary sources, especially fresh fruit and vegetables. The value of administering exogenous micronutrients, to reestablish antioxidant concentrations in patients with severe disease, has been recognized for decades. Despite the suggestion that ASC supplementation may reduce oxidative stress and prevent several chronic conditions, few large, randomized clinical trials have tested it in patients with severe illness. This article reviews the recent literature on the pharmacological profile of ASC and the role of its supplementation in critically ill patients.

Peptide Receptor Radionuclide Therapy in Advanced Refractory Meningiomas: Efficacy and Toxicity in a Long Follow-up

Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024

📚 19 citations🎯 RCR 5.15Top 7% NIH🔓 Open Access📄 PDF gratuit ↗

Phase IV postmarketing surveillance study shows continued efficacy and safety of Stempeucel in patients with critical limb ischemia due to Buerger's disease

Stem cells translational medicine · 2021

📚 17 citations🎯 RCR 1.35🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

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Abstract Buerger's disease or thromboangiitis obliterans is a type of obstructive vascular diseases categorized as vasculitis and usually present in 95% of young smoker men. The main pathogenetic mechanism is interplay between immune system and inflammation. Earlier our phase II study has shown that Stempeucel is safe when injected at 2 million cells/kg body weight by virtue of its anti-inflammatory, immunomodulatory, and angiogenetic properties. The present study was conducted to further assess the safety and efficacy of Stempeucel in critical limb ischemia due to Buerger's disease after obtaining approval from Indian FDA based on the data generated in the phase II study. This is an open label, multicenteric phase IV PMS study conducted across India with experienced vascular surgeons. Fifty patients of critical limb ischemia due to Buerger's disease with Rutherford III-5 or III-6 were included in the study and each individual received a dose of 2 million cells/kg body weight of Stempeucel in the calf muscles and around the ulcer. These patients were evaluated over 12 months from drug administration. The present study showed the continued long term efficacy over a period of 12 months follow up in these patients corroborating the result obtained in the previous phase II studies. There was significant improvement in rest pain, ankle systolic pressure, and ankle brachial pressure index with accelerated ulcer healing. In conclusion, the present study shows that the intramuscular administration of Stempeucel continues to be safe, tolerable, and effective alternative treatment in patients with Buerger's disease.

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MME MANUELA LECONTE-ANDRIES

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Top publications · les plus citées

Publications scientifiques (50) — classées par pathologie

Transversal26

Revue générale4

Arthrite juvénile2

Épidémiologie & registres2

Essai clinique2

Santé mentale / fatigue2

Vascularites des gros vaisseaux2

Vraie vie / RWE2

csDMARDs1

Génétique1

JAK inhibiteurs1

Lombalgie1

Lupus1

Maladie à IgG41

Pédiatrie1

Pharmacovigilance1

Qualité de vie / PROMs1

Revue / méta-analyse1

Sjögren1

Vascularites1

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