📇 Rhumatologue ·
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Praticien-chercheur
5 articles scientifiques publiés — formation continue solide
✨ Génération du profil synthétique IA en cours…
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BMC genomics · 2024
Abstract Background There are two major genetic types of Epstein-Barr Virus (EBV): type 1 (EBV-1) and type 2 (EBV-2). EBV functions by manipulating gene expression in host B cells, using virus-encoded gene regulatory proteins including Epstein-Barr Nuclear Antigen 2 (EBNA2). While type 1 EBNA2 is known to interact with human transcription factors (hTFs) such as RBPJ, EBF1, and SPI1 (PU.1), type 2 EBNA2 shares only ~ 50% amino acid identity with type 1 and thus may have distinct binding partners, human genome binding locations, and functions. Results In this study, we examined genome-wide EBNA2 binding in EBV-1 and EBV-2 transformed human B cells to identify shared and unique EBNA2 interactions with the human genome, revealing thousands of type-specific EBNA2 ChIP-seq peaks. Computational predictions based on hTF motifs and subsequent ChIP-seq experiments revealed that both type 1 and 2 EBNA2 co-occupy the genome with SPI1 and AP-1 (BATF and JUNB) hTFs. However, type 1 EBNA2 showed preferential co-occupancy with EBF1, and type 2 EBNA2 preferred RBPJ. These differences in hTF co-occupancy revealed possible mechanisms underlying type-specific gene expression of known EBNA2 human target genes: MYC (shared), CXCR7 (type 1 specific), and CD21 (type 2 specific). Both type 1 and 2 EBNA2 binding events were enriched at systemic lupus erythematosus (SLE) and multiple sclerosis (MS) risk loci, while primary biliary cholangitis (PBC) risk loci were specifically enriched for type 2 peaks. Conclusions This study reveals extensive type-specific EBNA2 interactions with the human genome, possible differences in EBNA2 interaction partners, and a possible new role for type 2 EBNA2 in autoimmune disorders. Our results highlight the importance of considering EBV type in the control of human gene expression and disease-related investigations.
The Journal of rheumatology · 1979
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
bioRxiv : the preprint server for biology · 2026 · Journal Article
Lawson LY, Chermside-Scabbo CJ, Brodt MD, Migotsky N, et al.
medRxiv : the preprint server for health sciences · 2026 · Journal Article
Virolainen SJ, Creighton K, Dashtiahangar M, Krishnamurthy D, et al.
BMC genomics · 2024 · Journal Article
Viel KCMF, Parameswaran S, Donmez OA, Forney CR, et al.
Arthritis care & research · 2026 · Journal Article
Weiner DK, Gentili A, Fang MA, Garay E, et al.
The Journal of rheumatology · 1979 · Case Reports
Stein HB, Dodek A, Lawson L, Rae A