📇 Rhumatologue ·
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1 raison identifiée
Encadrant universitaire
Forme la prochaine génération de rhumatologues (4 thèses dirigées)
10ans d'exercice (thèse 2016)
✨ Génération du profil synthétique IA en cours…
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.
ACTIVITE PHYSIQUE ADAPTEE CHEZ L’ENFANT TRAITE POUR CANCER ET INSULINOSENSIBILITE (APACIS)
Doctorant·e : Justine Thomas
Timing de l'alimentation et de l'exercice comme nouvelle stratégie pour préserver la masse musculaire et améliorer la santé métabolique de femmes obèses ménopausées et atteintes de diabète de type 2
Doctorant·e : Matthieu Marty
Prévention des altérations musculaires et métaboliques par l'exercice dans un modèle d’alitement prolongé : exploration des déterminants cellulaires et moléculaires
Doctorant·e : Jean-baptiste Chettouche
Dialogue muscle squelettique-tissu adipeux et prévention des altérations métaboliques liées au mode de vie et à l’âge
Doctorant·e : Lucas Frassin
Source theses.fr — signal de direction d'équipe / statut PU-PH (à confirmer via le site universitaire).
Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.
Influence scientifique
24
24 articles ont été cités au moins 24fois par d'autres chercheurs — preuve que ses travaux sont repris par la communauté médicale.
h-index
Total citations reçues
1 545
Nombre de fois où d'autres équipes ont mentionné ses publications dans leurs propres travaux.
Publications totales
58
Articles, revues et chapitres référencés dans les bases académiques internationales.
Articles influents
30
Publications ayant marqué leur domaine — chacune citée au moins 10 fois par d'autres chercheurs.
i10-index
Thématiques principales
Affiliations FR : Inserm · Université Fédérale de Toulouse Midi-Pyrénées · Centre de Recherche en Cancérologie de Toulouse
Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.
Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.
The impact of 60 days of -6° head down tilt bed rest on mitochondrial content, respiration and regulators of mitochondrial dynamics
2025ArticleThe Journal of Physiology
Study protocol of an early randomized intervention trial assessing the metabolic effects of two levels of exercise intensity in children undergoing cancer treatment: the APACIS study
2025ArticleBMC Cancer
Loss of atrial natriuretic peptide signaling causes insulin resistance, mitochondrial dysfunction, and low endurance capacity
2024ArticleScience Advances
GDF15 is dispensable for the insulin-sensitizing effects of chronic exercise
2024ArticleCell Reports
Common mouse models of chronic kidney disease are not associated with cachexia
2024ArticleCommunications Biology
Dialogue coeur-tissu adipeux brun: Rôle des peptides natriurétiques dans la pathogénèse du diabète de type 2
2024CongrèsCongrès annuel de la Société Francophone du Diabète
Comprehensive assessment of physiological responses in women during the ESA dry immersion VIVALDI microgravity simulation
2023ArticleNature Communications
Adipose tissue is a source of regenerative cells that augment the repair of skeletal muscle after injury
2023ArticleNature Communications
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Journal of cachexia, sarcopenia and muscle · 2021
AbstractBackgroundFasting is attracting an increasing interest as a potential strategy for managing diseases, including metabolic disorders and complementary cancer therapy. Despite concerns of clinicians regarding protein catabolism and muscle loss, evidence‐based clinical data in response to long‐term fasting in healthy humans are scarce. The objective of this study was to measure clinical constants, metabolic, and muscular response in healthy men during and after a 10 day fast combined with a physical activity programme.MethodsSixteen men (44 ± 14 years; 26.2 ± 0.9 kg/m2) fasted with a supplement of 200–250 kcal/day and up to 3 h daily low‐intensity physical activity according to the peer‐reviewed Buchinger Wilhelmi protocol. Changes in body weight (BW) and composition, basal metabolic rate (BMR), physical activity, muscle strength and function, protein utilization, inflammatory, and metabolic status were assessed during the 10 day fast, the 4 days of food reintroduction, and at 3 month follow‐up.ResultsThe 10 day fast decreased BW by 7% (−5.9 ± 0.2 kg, P < 0.001) and BMR by 12% (P < 0.01). Fat mass and lean soft tissues (LST) accounted for about 40% and 60% of weight loss, respectively, −2.3 ± 0.18 kg and −3.53 ± 0.13 kg, P < 0.001. LST loss was explained by the reduction in extracellular water (44%), muscle and liver glycogen and associated water (14%), and metabolic active lean tissue (42%). Plasma 3‐methyl‐histidine increased until Day 5 of fasting and then decreased, suggesting that protein sparing might follow early proteolysis. Daily steps count increased by 60% (P < 0.001) during the fasting period. Strength was maintained in non‐weight‐bearing muscles and increased in weight‐bearing muscles (+33%, P < 0.001). Glycaemia, insulinemia, blood lipids, and blood pressure dropped during the fast (P < 0.05 for all), while non‐esterified fatty acids and urinary beta‐hydroxybutyrate increased (P < 0.01 for both). After a transient reduction, inflammatory cytokines returned to baseline at Day 10 of fasting, and LST were still lower than baseline values (−2.3% and −3.2%, respectively; P < 0.05 for both).ConclusionsA 10 day fast appears safe in healthy humans. Protein loss occurs in early fast but decreases as ketogenesis increases. Fasting combined with physical activity does not negatively impact muscle function. Future studies will need to confirm these first findings.
Communications biology · 2024
AbstractThe 5/6 nephrectomy and adenine-induced nephropathy mouse models have been extensively used to study Chronic Kidney Disease (CKD)-related cachexia. One common caveat of these CKD models is the cross-sectional nature of comparisons made versus controls. We here performed a comprehensive longitudinal assessment of body composition and energy metabolism in both models. The most striking finding is that weight loss is largely driven by reduced food intake which promotes rapid loss of lean and fat mass. However, in both models, mice catch up weight and lean mass a few days after the surgery or when they are switched back to standard chow diet. Muscle force and mass are fully recovered and no sign of cachexia is observed. Our data demonstrate that the time-course of kidney failure and weight loss are unrelated in these common CKD models. These data highlight the need to reconsider the relative contribution of direct and indirect mechanisms to muscle wasting observed in CKD.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Communications medicine · 2026 · Journal Article
Robin A, Navasiolava N, Bergouignan A, Laurens C, et al.
Communications biology · 2024 · Journal Article
Lair B, Lac M, Frassin L, Brunet M, et al.
Journal of cachexia, sarcopenia and muscle · 2021 · Clinical Trial
Laurens C, Grundler F, Damiot A, Chery I, et al.
BMC cancer · 2025 · Clinical Trial Protocol
Thomas J, Filleron T, Auriol F, Laurens C, et al.
BMC cancer · 2025 · Clinical Trial Protocol
Thomas J, Filleron T, Auriol F, Laurens C, et al.
Five days of physical inactivity induced by dry immersion alter skeletal muscle metabolism and whole-body glucose tolerance in healthy men - Supplemental Data
Supplemental Data from the article "<b>Five days of physical inactivity induced by dry immersion alter skeletal muscle metabolism and </b><b><i>whole-body</i></b><b> </b><b>glucose tolerance in healthy men</b>"
<b>Common mouse models of chronic kidney disease are not associated with cachexia</b>
The 5/6 nephrectomy and adenine-induced nephropathy mouse models have been extensively used to study Chronic Kidney Disease (CKD)-related cachexia. One common caveat of these CKD models is the cross-sectional nature of c
Five days of physical inactivity induced by dry immersion alter skeletal muscle metabolism and whole-body glucose tolerance in healthy men - Supplemental Data
Supplemental Data from the article "<b>Five days of physical inactivity induced by dry immersion alter skeletal muscle metabolism and </b><b><i>whole-body</i></b><b> </b><b>glucose tolerance in healthy men</b>"
<b>Common mouse models of chronic kidney disease are not associated with cachexia</b>
The 5/6 nephrectomy and adenine-induced nephropathy mouse models have been extensively used to study Chronic Kidney Disease (CKD)-related cachexia. One common caveat of these CKD models is the cross-sectional nature of c
Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).