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2 raisons identifiées
Auteur de référence en rhumatologie
50 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
336.2 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
CABINET DU DR BERNARD LACROISADE
S O S MEDECINS 87 BOULEVARD DE PORT ROYAL, 75013 PARIS
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Critical care medicine · 2026
OBJECTIVES: To evaluate the diagnostic performance of a rapid point-of-care immunoassay measuring pancreatic stone protein (PSP) for early sepsis identification within the first three days of ICU admission. Subgroup analyses (sex, age, febrile status) were conducted, and the combined diagnostic value of PSP and C-reactive protein (CRP) was assessed. DESIGN: Multicenter, prospective, observational study. PATIENT: Four hundred sixty-six adults the ICU. SETTING: Six ICUs in the United States who were expected to required at least 24 hours of ICU care. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: We calculated the Youden Index to evaluate the clinical performance of the PSP assay, and the resulting threshold was used to identify patients with sepsis. Diagnostic performance metrics included sensitivity, specificity, accuracy, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (LR+), and negative likelihood ratio (LR–). Receiver operating characteristic analysis were performed for PSP and CRP. At the optimal PSP cutoff point of 117 ng/mL, PSP demonstrated a sensitivity of 74.2%, specificity of 67.8%, accuracy of 71.0%, PPV of 70.3%, NPV of 71.9%, and LR+ and LR– ratios of 2.30 and 0.38, respectively. Combining PSP and CRP improved diagnostic specificity to 95.2%. Subgroup analyses demonstrated consistent performance across sex, and higher specificity was observed in patients 18–60 years old. In febrile patients, PSP achieved high specificity (77.8%) but lower sensitivity (63.6%). In non-febrile patients, specificity and sensitivity sensitivity and specificity were 67.0% and 76.6%, respectively. CONCLUSIONS: PSP can serve as a biomarker for the early identification of sepsis. Diagnostic performance across diverse ages, sex, and clinical presentation supports the assay’s broad applicability. The combination of PSP and CRP enhances diagnostic specificity for sepsis detection, offering a complementary approach to improve sepsis detection and lead to earlier appropriate management.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
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The Journal of investigative dermatology · 2026 · Journal Article
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Nature medicine · 2026 · Journal Article
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Stem cell reports · 2026 · Journal Article
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American journal of veterinary research · 2026 · Journal Article
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The Journal of allergy and clinical immunology · 2026 · Journal Article
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The Pediatric infectious disease journal · 2026 · Journal Article
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Liver international : official journal of the International Association for the Study of the Liver · 2026 · Journal Article
Lambert V, Teglas JP, Ackermann O, Franchi-Abella S, et al.
Environmental research · 2026 · Systematic Review
Boitel A, Cot S, Pujol S, Martin B, et al.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026 · Journal Article
Wilson P, Doucette MM, Hossain R, Valencia BA, et al.
The Pediatric infectious disease journal · 2026 · Journal Article
Ward RM, Metz S, Bernard A, Clark JE
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AJNR. American journal of neuroradiology · 2026 · Journal Article
Wong AD, Airas L, Alvarez E, Antel J, et al.
The Journal of thoracic and cardiovascular surgery · 2026 · Journal Article
Bouchard D, Dreyfus J, Tourneau TL, Ternacle J, et al.