📇 Rhumatologue · VALENCIENNES CEDEX · (59) · Salarié

M XAVIER KYNDT

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Auteur de référence en rhumatologie
21 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
126.7 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 VALENCIENNES CEDEX (59)SalariéRPPS 10002297728

🇫🇷 Publications académiques françaises (6)

✨ Génération du profil synthétique IA en cours…

Publications académiques en France

Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.

Cytokine Signature in Schnitzler Syndrome: Proinflammatory Cytokine Production Associated to Th Suppression
2020
Article

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Azathioprine or methotrexate maintenance for ANCA-associated vasculitis

The New England journal of medicine · 2008

📚 433 citations🎯 RCR 13.80Top 1% NIH🩺 Clinique

Tolerance and short term efficacy of rituximab in 43 patients with systemic autoimmune diseases

Annals of the rheumatic diseases · 2005

📚 322 citations🎯 RCR 9.05Top 3% NIH🔓 Open Access📄 PDF gratuit ↗

Treatment of systemic necrotizing vasculitides in patients aged sixty-five years or older: results of a multicenter, open-label, randomized controlled trial of corticosteroid and cyclophosphamide-based induction therapy

Arthritis & rheumatology (Hoboken, N.J.) · 2015

📚 128 citations🎯 RCR 5.14Top 7% NIH🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

ObjectiveTo investigate a new therapeutic strategy, with rapid corticosteroid dose tapering and limited cyclophosphamide (CYC) exposure, for older patients with systemic necrotizing vasculitides (SNVs; polyarteritis nodosa [PAN], granulomatosis with polyangiitis [Wegnener's] [GPA], microscopic polyangiitis [MPA], or eosinophilic GPA [Churg‐Strauss] [EGPA]).MethodsA multicenter, open‐label, randomized controlled trial comprising patients ≥65 years old and newly diagnosed as having SNV was conducted. The experimental treatment consisted of corticosteroids for ∼9 months and a maximum of six 500‐mg fixed‐dose intravenous (IV) CYC pulses, every 2–3 weeks, then maintenance azathioprine or methotrexate. The control treatment included ∼26 months of corticosteroids for all patients, combined with 500 mg/m2 IV CYC pulses, every 2–3 weeks until remission, then maintenance for all patients with GPA or MPA and for those with EGPA or PAN with a Five‐Factors Score (FFS) of ≥1. Randomization used a 1:1 ratio computer‐generated list and was performed centrally with sealed opaque envelopes. The primary outcome measure was ≥1 serious adverse event (SAE) occurring within 3 years of followup. Secondary outcome measures included remission and relapse rates.ResultsAmong the 108 patients randomized, 4 were excluded (early consent withdrawal or protocol violation). Mean ± SD age at diagnosis was 75.2 ± 6.3 years. Analysis at 3 years included 53 patients (21 GPA, 21 MPA, 8 EGPA, and 3 PAN) in the experimental arm and 51 patients (15 GPA, 23 MPA, 6 EGPA, and 7 PAN) in the conventional arm. In total, 32 (60%) versus 40 (78%) had ≥1 SAE (P = 0.04), most frequently infections; 6 (11%) versus 7 (14%) failed to achieve remission (P = 0.71); 9 (17%) versus 12 (24%) died (P = 0.41); and 20 (44%) of 45 versus 12 (29%) of 41 survivors in remission experienced a relapse (P = 0.15).ConclusionFor older SNV patients, an induction regimen limiting corticosteroid exposure and with fixed low‐dose IV CYC pulses reduces SAEs in comparison to conventional therapy, and does not affect the remission rate. Three‐year relapse rates remain high for both arms.

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M XAVIER KYNDT

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Publications académiques en France

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Top publications · les plus citées

Publications scientifiques (21) — classées par pathologie

Transversal5

Vascularites4

Sclérodermie3

Essai clinique2

Biothérapies non-anti-TNF1

Case report / série1

Corticothérapie1

csDMARDs1

Lupus1

Pharmacovigilance1

Risque cardio-vasculaire1

SAPL1

Sjögren1

Vraie vie / RWE1

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