📇 Rhumatologue · PARIS CEDEX 10 · (75) · Hospitalier
Chargement de la fiche…
Chargement de la fiche…
MonRhumato.fr utilise des cookies pour mesurer l'audience (statistiques) et améliorer le site. Aucune donnée de santé identifiable n'est jamais collectée. Politique de confidentialité.
Votre choix est conservé 13 mois (durée max CNIL). Vous pouvez le modifier à tout moment via Préférences cookies.
4 raisons identifiées
Plateau technique de référence
Assistance publique – Hôpitaux de Paris (APHP) — équipements et expertise pointus pour les cas complexes
Encadrant universitaire
Forme la prochaine génération de rhumatologues (2 thèses dirigées)
Praticien-chercheur
16 articles scientifiques publiés — formation continue solide
Délais de RDV courts dans la région
336.2 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Source theses.fr — signal de direction d'équipe / statut PU-PH (à confirmer via le site universitaire).
Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.
Influence scientifique
34
34 articles ont été cités au moins 34fois par d'autres chercheurs — preuve que ses travaux sont repris par la communauté médicale.
h-index
Total citations reçues
3 709
Nombre de fois où d'autres équipes ont mentionné ses publications dans leurs propres travaux.
Publications totales
159
Articles, revues et chapitres référencés dans les bases académiques internationales.
Articles influents
67
Publications ayant marqué leur domaine — chacune citée au moins 10 fois par d'autres chercheurs.
i10-index
Thématiques principales
Affiliations FR : Délégation Paris 5 · Inserm · Université Paris Cité
Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.
Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.
The role of the choroidal nervous system in central serous chorioretinopathy and associated diseases
2026ArticleProgress in Retinal and Eye Research
How should clinicians interpret these results?
2025ArticleEuropean Journal of Anaesthesiology
EEG and acute confusional state at the emergency department
2024ArticleNeurophysiologie Clinique = Clinical Neurophysiology
Prognostic value of early EEG abnormalities in severe stroke patients requiring mechanical ventilation: a pre-planned analysis of the SPICE prospective multicenter study
2024ArticleCritical Care
Author Correction: Rapid decline of neutralizing antibodies against SARS-CoV-2 among infected healthcare workers
2021ArticleNature Communications
Increased serum QUIN/KYNA is a reliable biomarker of post-stroke cognitive decline
2021ArticleMolecular Neurodegeneration
Endothelial S1P 1 Signaling Counteracts Infarct Expansion in Ischemic Stroke
2021ArticleCirculation Research
Long-Term Disabilities of Survivors of Out-of-Hospital Cardiac Arrest
2021ArticleChest
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
GHU APHP NUP SITE LARIBOISIERE
2 R AMBROISE PARE, 75475 PARIS CEDEX 10
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Hypertension (Dallas, Tex. : 1979) · 2015
Cerebrovascular impairment is frequent in patients with Alzheimer disease and is believed to influence clinical manifestation and severity of the disease. Cardiovascular risk factors, especially hypertension, have been associated with higher risk of developing Alzheimer disease. To investigate the mechanisms underlying the hypertension, Alzheimer disease cross talk, we established a mouse model of dual pathology by infusing hypertensive doses of angiotensin II into transgenic APPPS1 mice overexpressing mutated human amyloid precursor and presenilin 1 proteins. At 4.5 months, at the early stage of disease progression, only hypertensive APPPS1 mice presented impairment of temporal order memory performance in the episodic-like memory task. This cognitive deficit was associated with an increased number of cortical amyloid deposits (223±5 versus 207±5 plaques/mm 2 ; P <0.05) and a 2-fold increase in soluble amyloid levels in the brain and in plasma. Hypertensive APPPS1 mice presented several cerebrovascular alterations, including a 25% reduction in cerebral microvessel density and a 30% to 40% increase in cerebral vascular amyloid deposits, as well as a decrease in vascular endothelial growth factor A expression in the brain, compared with normotensive APPPS1 mice. Moreover, the brain levels of nitric oxide synthase 1 and 3 and the nitrite/nitrate levels were reduced in hypertensive APPPS1 mice (by 49%, 34%, and 33%, respectively, compared with wild-type mice; P <0.05). Our results indicate that hypertension accelerates the development of Alzheimer disease–related structural and functional alterations, partially through cerebral vasculature impairment and reduced nitric oxide production.
Critical care (London, England) · 2018
Molecular neurodegeneration · 2021
Abstract Background Strokes are becoming less severe due to increased numbers of intensive care units and improved treatments. As patients survive longer, post-stroke cognitive impairment (PSCI) has become a major health public issue. Diabetes has been identified as an independent predictive factor for PSCI. Here, we characterized a clinically relevant mouse model of PSCI, induced by permanent cerebral artery occlusion in diabetic mice, and investigated whether a reliable biomarker of PSCI may emerge from the kynurenine pathway which has been linked to inflammatory processes. Methods Cortical infarct was induced by permanent middle cerebral artery occlusion in male diabetic mice (streptozotocin IP). Six weeks later, cognitive assessment was performed using the Barnes maze, hippocampi long-term potentiation using microelectrodes array recordings, and neuronal death, white matter rarefaction and microglia/macrophages density assessed in both hemispheres using imunohistochemistry. Brain and serum metabolites of the kynurenin pathway were measured using HPLC and mass fragmentography. At last, these same metabolites were measured in the patient’s serum, at the acute phase of stroke, to determine if they could predict PSCI 3 months later. Results We found long-term spatial memory was impaired in diabetic mice 6 weeks after stroke induction. Synaptic plasticity was completely suppressed in both hippocampi along with increased neuronal death, white matter rarefaction in both striatum, and increased microglial/macrophage density in the ipsilateral hemisphere. Brain and serum quinolinic acid concentrations and quinolinic acid over kynurenic acid ratios were significantly increased compared to control, diabetic and non-diabetic ischemic mice, where PSCI was absent. These putative serum biomarkers were strongly correlated with degradation of long-term memory, neuronal death, microglia/macrophage infiltration and white matter rarefaction. Moreover, we identified these same serum biomarkers as potential predictors of PSCI in a pilot study of stroke patients. Conclusions we have established and characterized a new model of PSCI, functionally and structurally, and we have shown that the QUIN/KYNA ratio could be used as a surrogate biomarker of PSCI, which may now be tested in large prospective studies of stroke patients.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026 · Journal Article
Gravier A, Obadia MA, Thibault JL, Delmaire C, et al.
Muscle & nerve · 2026 · Journal Article
Le Vavasseur M, Blaise C, Cordelle I, Reach P, et al.
Journal of neurology · 2021 · Journal Article
Bicart-Sée L, Thibault JL, Poujois A, Woimant F, et al.
Ultraschall in der Medizin (Stuttgart, Germany : 1980) · 2020 · Journal Article
El Sanharawi I, Barral M, Lenck S, Dillinger JG, et al.
Journal of medical genetics · 2020 · Clinical Trial
Nasser H, Vera L, Elmaleh-Bergès M, Steindl K, et al.
Angiogenesis · 2018 · Journal Article
Merkulova-Rainon T, Mantsounga CS, Broquères-You D, Pinto C, et al.
Journal of rehabilitation medicine · 2018 · Journal Article
Provost CP, Tasseel-Ponche S, Lozeron P, Piccinini G, et al.
Journal of neural transmission (Vienna, Austria : 1996) · 2017 · Journal Article
Lozeron P, Poujois A, Meppiel E, Masmoudi S, et al.
Hypertension (Dallas, Tex. : 1979) · 2017 · Evaluation Study
Cifuentes D, Poittevin M, Bonnin P, Ngkelo A, et al.
The Keio journal of medicine · 2017 · Journal Article
Kubis N
Frontiers in neural circuits · 2016 · Journal Article
Lozeron P, Poujois A, Richard A, Masmoudi S, et al.
European radiology · 2015 · Evaluation Study
Deroide N, Bousson V, Mambre L, Vicaut E, et al.
Hypertension (Dallas, Tex. : 1979) · 2015 · Journal Article
Cifuentes D, Poittevin M, Dere E, Broquères-You D, et al.
European journal of neurology · 2025 · Journal Article
Chakroun S, Faucher A, Gueguen A, Fadlallah J, et al.
Critical care (London, England) · 2018 · Journal Article
Azabou E, Navarro V, Kubis N, Gavaret M, et al.
Molecular neurodegeneration · 2021 · Journal Article
Cogo A, Mangin G, Maïer B, Callebert J, et al.
Critical care (London, England) · 2018 · Journal Article
Azabou E, Navarro V, Kubis N, Gavaret M, et al.
Increased serum QUIN/KYNA is a reliable biomarker of post-stroke cognitive decline
Abstract Background Strokes are becoming less severe due to increased numbers of intensive care units and improved treatments. As patients survive longer, post-stroke cognitive impairment (PSCI) has become a major health
Simplified frontal EEG in adults under veno-arterial extracorporeal membrane oxygenation
Abstract Background EEG-based prognostication studies in intensive care units often rely on a standard 21-electrode montage (stdEEG) requiring substantial human, technical, and financial resources. We here evaluate wheth
Prognostic value of early EEG abnormalities in severe stroke patients requiring mechanical ventilation: a pre-planned analysis of the SPICE prospective multicenter study
Abstract Introduction Prognostication of outcome in severe stroke patients necessitating invasive mechanical ventilation poses significant challenges. The objective of this study was to assess the prognostic significance
Simplified frontal EEG in adults under veno-arterial extracorporeal membrane oxygenation
Abstract Background EEG-based prognostication studies in intensive care units often rely on a standard 21-electrode montage (stdEEG) requiring substantial human, technical, and financial resources. We here evaluate wheth
Additional file 1 of Simplified frontal EEG in adults under veno-arterial extracorporeal membrane oxygenation
Additional file 1. Synek classification.
Increased serum QUIN/KYNA is a reliable biomarker of post-stroke cognitive decline
Abstract Background Strokes are becoming less severe due to increased numbers of intensive care units and improved treatments. As patients survive longer, post-stroke cognitive impairment (PSCI) has become a major health
Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).