M JEAN-FRANCOIS KLEIN

Rhumatologue

RPPS 10001787851

📊 Reconnaissance scientifique : 3/100📝 77 articles publiés🇫🇷 Publications académiques françaises (8)

✨ Profil synthétique

IA · 22/05/2026

Le Dr Jean-François Klein est un rhumatologue avec une production scientifique diversifiée, comprenant 77 publications et un h-index de 3. Ses recherches couvrent des domaines variés, allant de l'histoire et de la culture à la médecine, avec une focalisation sur certaines pathologies rhumatologiques. Il a publié sur des sujets tels que l'imagerie ostéo-articulaire, la génétique, le syndrome de Sjögren, et les essais cliniques.

Expertises présumées

IRM ostéo-articulaire
Syndrome de Sjögren
Génétique des maladies rhumatismales
Épidémiologie des maladies rhumatismales
Essais cliniques en rhumatologie
Imagerie médicale en rhumatologie

Synthèse automatique à partir des sources publiques (HAL, OpenAlex, theses.fr, ClinicalTrials.gov, FAI²R, ANS). Pas une évaluation clinique. Le médecin peut corriger via son compte.

✨ Génération du profil synthétique IA en cours…

Activité de recherche & publications

Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.

Influence scientifique

3 articles ont été cités au moins 3fois par d'autres chercheurs — preuve que ses travaux sont repris par la communauté médicale.

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Recent Progress in Cartilage Lubrication

Advanced materials (Deerfield Beach, Fla.) · 2021

📚 245 citations🎯 RCR 21.48Top 1% NIH

Lire l'abstract Crossref ↓

Abstract Healthy articular cartilage, covering the ends of bones in major joints such as hips and knees, presents the most efficiently‐lubricated surface known in nature, with friction coefficients as low as 0.001 up to physiologically high pressures. Such low friction is indeed essential for its well‐being. It minimizes wear‐and‐tear and hence the cartilage degradation associated with osteoarthritis, the most common joint disease, and, by reducing shear stress on the mechanotransductive, cartilage‐embedded chondrocytes (the only cell type in the cartilage), it regulates their function to maintain homeostasis. Understanding the origins of such low friction of the articular cartilage, therefore, is of major importance in order to alleviate disease symptoms, and slow or even reverse its breakdown. This progress report considers the relation between frictional behavior and the cellular mechanical environment in the cartilage, then reviews the mechanism of lubrication in the joints, in particular focusing on boundary lubrication. Following recent advances based on hydration lubrication, a proposed synergy between different molecular components of the synovial joints, acting together in enabling the low friction, has been proposed. Additionally, recent development of natural and bio‐inspired lubricants is reviewed.

Lubrication of Articular Cartilage

Annual review of biomedical engineering · 2016

📚 226 citations🎯 RCR 10.97Top 2% NIH

Lire l'abstract Crossref ↓

The major synovial joints such as hips and knees are uniquely efficient tribological systems, able to articulate over a wide range of shear rates with a friction coefficient between the sliding cartilage surfaces as low as 0.001 up to pressures of more than 100 atm. No human-made material can match this. The means by which such surfaces maintain their very low friction has been intensively studied for decades and has been attributed to fluid-film and boundary lubrication. Here, we focus especially on the latter: the reduction of friction by molecular layers at the sliding cartilage surfaces. In particular, we discuss such lubrication in the light of very recent advances in our understanding of boundary effects in aqueous media based on the paradigms of hydration lubrication and of the synergism between different molecular components of the synovial joints (namely hyaluronan, lubricin, and phospholipids) in enabling this lubrication.

Demographic and medical parameters in the development of complex regional pain syndrome type 1 (CRPS1): prospective study on 596 patients with a fracture

Pain · 2012

📚 144 citations🎯 RCR 6.48Top 5% NIH

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M JEAN-FRANCOIS KLEIN

Pourquoi vous devez consulter ce praticien

Activité de recherche & publications

Publications académiques en France

Lieu de consultation

Tarifs & secteur de conventionnement

Prendre rendez-vous & contact

Articles de presse (1)

Top publications · les plus citées

Publications scientifiques (29) — classées par pathologie

Transversal14

IRM ostéo-articulaire3

Revue générale3

Génétique2

Sjögren2

Épidémiologie & registres1

Essai clinique1

IA en rhumatologie1

Lupus1

Pédiatrie1

Revue / méta-analyse1

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