📇 Rhumatologue · MANTES LA JOLIE · (78) · Salarié

M Ali KHALED

Pourquoi vous devez consulter ce praticien

3 raisons identifiées

Auteur de référence en rhumatologie
23 articles scientifiques publiés — un praticien à la pointe de la recherche
Référence presse grand public
Cité 6 fois dans les médias — pédagogie reconnue
Délais de RDV courts dans la région
86.1 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 MANTES LA JOLIE (78)SalariéRPPS 10003116687

📊 Reconnaissance scientifique : 5/100📝 8 articles publiés🇫🇷 Publications académiques françaises (7)

✨ Génération du profil synthétique IA en cours…

Activité de recherche & publications

Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.

Influence scientifique

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Articles de presse (6)

Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).

"Je suis arrivé en fauteuil roulant": une clinique répare les corps des consommateurs de protoxyde d'azote à Mantes-la-Jolie - BFM

📰 BFM · 22/02/2026

<a href="https://news.google.com/rss/articles/CBMihAJBVV95cUxNSzhlWFYwRTAtZWxoRzhwSzk3LWE4MG1NRFVxNW11V0ZBVGNPMWlWLV9TZ3luTjVrM3JvdTR2UkhERVo0VVpXdUd3YXdRV0N6eFBoUWhQclZGVFdKUDdlNGRTYzA0RmJ1TnFvaWJsdV9kd2xYNEROczJlSENzQWNRRFVxcG9LMkhpb3dqYUpubGJRYkNiU1RaSVcxSkNXdHRNdzVITmVuSklNby13TzRXSXI3dUUtelFQdD

"C'est vraiment un fléau" : consommateurs, proches et médecins décrivent les vies brisées par le protoxyde d'azote - franceinfo

📰 franceinfo · 30/12/2025

<a href="https://news.google.com/rss/articles/CBMioAFBVV95cUxOYmhtaHVLZzlEeEtPWXJzVUhqdDB1cUNqOTRXNkU5T3V2aFdjMzRGRWd2NG9PYzFQUXByS0R5NWRUN0VFRGlKYjZ3dUdVUzItNGNMem5ENzdMdjlaUWRBS0pnYkVBZGpRMU0tVGRoVkNsRmt5aU5yRXFJVFcyRXV5cE1kWnZlUGxWaHByRG9jUXpoSW54VU1fVU12T3dpb2du?oc=5" target="_blank">"C'est vrai

Protoxyde d'azote, le gaz paralysant - Radio France

📰 Radio France · 22/03/2026

<a href="https://news.google.com/rss/articles/CBMiqgFBVV95cUxNY3dtVUtCRWRjYWtiNFFDNThRamFnOVFlam91bV9tWmZRc3VSNGZfVmF4THJRMkdnVjg5NndlWnY2cVBYUGw3enUxUUFVNVR1ejFlM0x3anpJX1RET04yckpweWpFYWJJY2U0U20wVk1SU1NfaGJ4aEFaRGR6d0k5UjJDd05FaWZMR3BnQ0ladlpTRDYwUzRUN1dZMzUtbmhkbGt3Y210ejVRZw?oc=5" target="_blan

Protoxyde d’azote : ce patron de cliniques part en croisade contre le « gaz hilarant » - Le Parisien

📰 Le Parisien · 18/11/2025

<a href="https://news.google.com/rss/articles/CBMi8AFBVV95cUxQMGRZclVQS0VqbGpUX05udm56cXdMOHJEM0dYU1FXVDZ0SHFDZmJZUEJESk91aHhhSkYyUjQ0MV9PNzVaWmhtbENJemdpTzhrNkpxdVBpeDFXTlJoYTVoZ3JMckRXaDA1d2pJU3BwRmtXc0dDMlRsSzR6VlY3Z2ducEkzZktNOUd6Yy1pUVZvWTREOUctNmlNWE82dXg5YlhPRWZsZDVSTmk3bFZOQUVYQkhWektuQ3Nyb2

« On m’avait prévenu, mais je n’ai pas écouté » : Mohamed, 25 ans, handicapé à cause du protoxyde d’azote - Le Parisien

📰 Le Parisien · 18/11/2025

<a href="https://news.google.com/rss/articles/CBMikwJBVV95cUxORGtSNWZtRExVbGV4cWpqRF9pcGZlb3BZc1NfZC1nVHgwSlVnUjU3cEtxOE1jUnpxXzVnQmNLT0hQWjdQbExMV19US0pRTkhPZDNsYjNwWGxEOUg3azJHejhaMGthdkdGdE0xckYxRGJIemlHOXNjcEc2UXBOTWZPQXpfSzFJZ2R2Sk9PNUlDbUxYUTJmRUpsdk90WmFfQVh6elRGWXp4OXVmdHQ0WEdkWklTY1U4Q0xrc1

"Un poison total" : le protoxyde d'azote, la drogue légale qui fait des ravages - Radio France

📰 Radio France · 20/03/2026

<a href="https://news.google.com/rss/articles/CBMi4wFBVV95cUxNMmwyX08xcGFUeS1IN3drTFJFUC10ZlJXWlZyRGF6VkV5MWh5MXVGd0d1MXlGMHc5N3RkWHU0RXhHZHR6bkc5R1BHYTlhcE9JbVRvdGFrNXI2VlB2RXRnYi1xVF9TWlRJX1RoXzhTVGNvUy1fcWNtOVBpcFhwU01oRHd4eGk4a214bWdjc2kxc3dOd1NjM0dUWHQ1Q2o5YUJ5ZkpvSG1KLXk1bDlqNkhxYlZQTncxS0xkQ1

Top publications · les plus citées

Impact of Back-to-Base Normothermic Machine Perfusion on Complications and Costs: A Multicenter, Real-World Risk-Matched Analysis

Annals of surgery · 2024

📚 60 citations🎯 RCR 15.42Top 1% NIH

Lire l'abstract Crossref ↓

Objective: Assess cost and complication outcomes after liver transplantation (LT) using normothermic machine perfusion (NMP). Background: End-ischemic NMP is often used to aid logistics, yet its impact on outcomes after LT remains unclear, as does its true impact on costs associated with transplantation. Methods: Deceased donor liver recipients at 2 centers (January 1, 2019, to June 30, 2023) were included. Retransplants, splits, and combined grafts were excluded. End-ischemic NMP (OrganOx-Metra) was implemented in October 2022 for extended-criteria donation after brain death (DBDs), all donations after circulatory deaths (DCDs), and logistics. NMP cases were matched 1:2 with static cold storage controls (SCS) using the Balance-of-Risk [donation after brain death (DBD)-grafts] and UK-DCD Score (DCD-grafts). Results: Overall, 803 transplantations were included, 174 (21.7%) receiving NMP. Matching was achieved between 118 NMP-DBDs with 236 SCS; and 37 NMP-DCD with 74 corresponding SCS. For both graft types, median inpatient comprehensive complications index values were comparable between groups. DCD-NMP grafts experienced reduced cumulative 90-day comprehensive complications index (27.6 vs 41.9, P=0.028). NMP also reduced the need for early relaparotomy and renal replacement therapy, with subsequently less frequent major complications (Clavien-Dindo ≥IVa). This effect was more pronounced in DCD transplants. NMP had no protective effect on early biliary complications. Organ acquisition/preservation costs were higher with NMP, yet NMP-treated grafts had lower 90-day pretransplant costs in the context of shorter waiting list times. Overall costs were comparable for both cohorts. Conclusions: This is the first risk-adjusted outcome and cost analysis comparing NMP and SCS. In addition to logistical benefits, NMP was associated with a reduction in relaparotomy and bleeding in DBD grafts, and overall complications and post-LT renal replacement for DCDs. While organ acquisition/preservation was more costly with NMP, overall 90-day health care costs-per-transplantation were comparable.

Acute rejection after liver transplantation with machine perfusion versus static cold storage: A systematic review and meta-analysis

Hepatology (Baltimore, Md.) · 2023

📚 48 citations🎯 RCR 7.48Top 4% NIH

Lire l'abstract Crossref ↓

Background and Aims: Acute cellular rejection (ACR) is a frequent complication after liver transplantation. By reducing ischemia and graft damage, dynamic preservation techniques may diminish ACR. We performed a systematic review to assess the effect of currently tested organ perfusion (OP) approaches versus static cold storage (SCS) on post-transplant ACR-rates. Approach and Results: A systematic search of Medline, Embase, Cochrane Library, and Web of Science was conducted. Studies reporting ACR-rates between OP and SCS and comprising at least 10 liver transplants performed with either hypothermic oxygenated perfusion (HOPE), normothermic machine perfusion, or normothermic regional perfusion were included. Studies with mixed perfusion approaches were excluded. Eight studies were identified (226 patients in OP and 330 in SCS). Six studies were on HOPE, one on normothermic machine perfusion, and one on normothermic regional perfusion. At meta-analysis, OP was associated with a reduction in ACR compared with SCS [OR: 0.55 (95% CI, 0.33–0.91), p=0.02]. This effect remained significant when considering HOPE alone [OR: 0.54 (95% CI, 0.29–1), p=0.05], in a subgroup analysis of studies including only grafts from donation after cardiac death [OR: 0.43 (0.20–0.91) p=0.03], and in HOPE studies with only donation after cardiac death grafts [OR: 0.37 (0.14–1), p=0.05]. Conclusions: Dynamic OP techniques are associated with a reduction in ACR after liver transplantation compared with SCS. PROSPERO registration: CRD42022348356.

A novel multifunctional radioprotective strategy using P7C3 as a countermeasure against ionizing radiation-induced bone loss

Bone research · 2023

📚 19 citations🎯 RCR 2.85Top 17% NIH🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

AbstractRadiotherapy is a critical component of cancer care but can cause osteoporosis and pathological insufficiency fractures in surrounding and otherwise healthy bone. Presently, no effective countermeasure exists, and ionizing radiation-induced bone damage continues to be a substantial source of pain and morbidity. The purpose of this study was to investigate a small molecule aminopropyl carbazole named P7C3 as a novel radioprotective strategy. Our studies revealed that P7C3 repressed ionizing radiation (IR)-induced osteoclastic activity, inhibited adipogenesis, and promoted osteoblastogenesis and mineral deposition in vitro. We also demonstrated that rodents exposed to clinically equivalent hypofractionated levels of IR in vivo develop weakened, osteoporotic bone. However, the administration of P7C3 significantly inhibited osteoclastic activity, lipid formation and bone marrow adiposity and mitigated tissue loss such that bone maintained its area, architecture, and mechanical strength. Our findings revealed significant enhancement of cellular macromolecule metabolic processes, myeloid cell differentiation, and the proteins LRP-4, TAGLN, ILK, and Tollip, with downregulation of GDF-3, SH2B1, and CD200. These proteins are key in favoring osteoblast over adipogenic progenitor differentiation, cell matrix interactions, and shape and motility, facilitating inflammatory resolution, and suppressing osteoclastogenesis, potentially via Wnt/β-catenin signaling. A concern was whether P7C3 afforded similar protection to cancer cells. Preliminarily, and remarkably, at the same protective P7C3 dose, a significant reduction in triple-negative breast cancer and osteosarcoma cell metabolic activity was found in vitro. Together, these results indicate that P7C3 is a previously undiscovered key regulator of adipo-osteogenic progenitor lineage commitment and may serve as a novel multifunctional therapeutic strategy, leaving IR an effective clinical tool while diminishing the risk of adverse post-IR complications. Our data uncover a new approach for the prevention of radiation-induced bone damage, and further work is needed to investigate its ability to selectively drive cancer cell death.

Cookies & analyse de trafic

M Ali KHALED

Pourquoi vous devez consulter ce praticien

Activité de recherche & publications

Publications académiques en France

Lieu de consultation

Tarifs & secteur de conventionnement

Prendre rendez-vous & contact

Articles de presse (6)

Top publications · les plus citées

Publications scientifiques (23) — classées par pathologie

Transversal8

Revue / méta-analyse5

Revue générale4

Case report / série3

Essai clinique3

Vraie vie / RWE2

Épidémiologie & registres1

Microbiote1

Pédiatrie1

SAPL1

Partager cette fiche