📇 Rhumatologue · CAYENNE CEDEX · (973) · Hospitalier
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2 raisons identifiées
Auteur de référence en rhumatologie
22 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
59.7 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
CENTRE HOSPITALIER DE CAYENNE
AV ALEXIS BLAISE BP 6006, 97306 CAYENNE CEDEX
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Revue du rhumatisme (English ed.) · 1998
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia · 2008
Microbiology spectrum · 2024
ABSTRACT Candidiasis places a significant burden on human health and can range from common superficial vulvovaginal and oral infections to invasive diseases with high mortality. The most common Candida species implicated in human disease is Candida albicans , but other species like Candida glabrata are emerging. The use of azole antifungals for treatment is limited by increasing rates of resistance. This study explores repositioning bisphosphonates, which are traditionally used for osteoporosis, as antifungal synergists that can improve and revitalize the use of azoles. Risedronate, alendronate, and zoledronate (ZOL) were tested against isolates from six different species of Candida , and ZOL produced moderate antifungal activity and strong synergy with azoles like fluconazole (FLC), particularly in C. glabrata . FLC:ZOL combinations had increased fungicidal and antibiofilm activity compared to either drug alone, and the combination prevented the development of antifungal resistance. Mechanistic investigations demonstrated that the synergy was mediated by the depletion of squalene, resulting in the inhibition of ergosterol biosynthesis and a compromised membrane structure. In C. glabrata , synergy compromised the function of membrane-bound multidrug transporters and caused an accumulation of reactive oxygen species, which may account for its acute sensitivity to FLC:ZOL. The efficacy of FLC:ZOL in vivo was confirmed in a Galleria mellonella infection model, where combinations improved the survival of larvae infected with C. albicans and C. glabrata to a greater extent than monotherapy with FLC or ZOL, and at reduced dosages. These findings demonstrate that bisphosphonates and azoles are a promising new combination therapy for the treatment of topical candidiasis. IMPORTANCE Candida is a common and often very serious opportunistic fungal pathogen. Invasive candidiasis is a prevalent cause of nosocomial infections with a high mortality rate, and mucocutaneous infections significantly impact the quality of life of millions of patients a year. These infections pose substantial clinical challenges, particularly as the currently available antifungal treatment options are limited in efficacy and often toxic. Azoles are a mainstay of antifungal therapy and work by targeting the biosynthesis of ergosterol. However, there are rising rates of acquired azole resistance in various Candida species, and some species are considered intrinsically resistant to most azoles. Our research demonstrates the promising therapeutic potential of synergistically enhancing azoles with non-toxic, FDA-approved bisphosphonates. Repurposing bisphosphonates as antifungal synergists can bypass much of the drug development pipeline and accelerate the translation of azole–bisphosphonate combination therapy.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia · 2008 · Journal Article
Niang A, Ka EF, Dia D, Pouye A, et al.
Dakar medical · 2008 · English Abstract
Diallo S, Dia D, Fall S, Kâne A, et al.
Dakar medical · 2007 · Comparative Study
Dia D, Ka EF, Cissé M, Pouye A, et al.
Dakar medical · 2007 · Case Reports
Seck SM, Dia D, Cissé MM, Guèye A, et al.
Annales de biologie clinique · 2006 · English Abstract
Touré AO, Doupa D, Diop S, Kane A, et al.
Dakar medical · 2005 · Journal Article
Diallo M, Kane A, Sy N, Ndiaye B
Dakar medical · 2004 · English Abstract
Diaof M, Ba SA, Kane A, Sarr M, et al.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2000 · Case Reports
Sy MH, Konaté I, Gassama A, Kane A, et al.
Dakar medical · 2000 · Case Reports
Kane A, Dia AA, Diop IB, Sarr M, et al.
Annales de dermatologie et de venereologie · 1996 · Case Reports
Kane A, Dereure O, Guilhou JJ
Practical neurology · 2021 · Case Reports
Kopanidis PC, Kane A, Nguyen MA, Markus R
Bulletin de la Societe de pathologie exotique (1990) · 2016 · Journal Article
Ngaïdé AA, Ly F, Ly K, Diao M, et al.
Annales de biologie clinique · 2014 · English Abstract
Diallo MS, Mbengue B, Seck A, Ndao AC, et al.
The Pan African medical journal · 2012 · Journal Article
Diao M, Ndiaye MB, Kane A, Bodian M, et al.
Presse medicale (Paris, France : 1983) · 1997 · English Abstract
Kane A, Kane A, Ba SA, Barry F, et al.
Dakar medical · 1990 · Case Reports
Hane AA, Ndir M, Badiane M, Ayad M, et al.
Microbiology spectrum · 2024 · Journal Article
Kane A, Dinh H, Campbell L, Cain AK, et al.
Dakar medical · 2007 · Comparative Study
Diallo M, Niang SO, Kane A, Dieng MT, et al.
Case reports in oncology · 2023 · Case Reports
Smith AE, Kane A, Watts F, Qiu M, et al.
Dakar medical · 2007 · English Abstract
Fall S, Dia D, Ka EF, Diallo S, et al.
Revue du rhumatisme (English ed.) · 1998 · Comparative Study
Ka MM, Diallo S, Kane A, Wade B, et al.
Bulletin de la Societe de pathologie exotique (1990) · 1998 · Journal Article
Ka MM, Diouf B, Mbengue M, Kane A, et al.