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Plateau technique de référence
Centre hospitalier universitaire (CHU) — équipements et expertise pointus pour les cas complexes
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17 articles scientifiques publiés — formation continue solide
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134.8 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
HOPITAL MAISON BLANCHE CHU REIMS
45 R COGNACQ JAY, 51092 REIMS CEDEX
CABINET DU DR PATOINLOUKOUBA PROSPER KADIYOGO
38 RUE ARISTIDE BRIAND, 51350 CORMONTREUIL
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Current genomics · 2014
Stem cells translational medicine · 2021
Abstract Buerger's disease or thromboangiitis obliterans is a type of obstructive vascular diseases categorized as vasculitis and usually present in 95% of young smoker men. The main pathogenetic mechanism is interplay between immune system and inflammation. Earlier our phase II study has shown that Stempeucel is safe when injected at 2 million cells/kg body weight by virtue of its anti-inflammatory, immunomodulatory, and angiogenetic properties. The present study was conducted to further assess the safety and efficacy of Stempeucel in critical limb ischemia due to Buerger's disease after obtaining approval from Indian FDA based on the data generated in the phase II study. This is an open label, multicenteric phase IV PMS study conducted across India with experienced vascular surgeons. Fifty patients of critical limb ischemia due to Buerger's disease with Rutherford III-5 or III-6 were included in the study and each individual received a dose of 2 million cells/kg body weight of Stempeucel in the calf muscles and around the ulcer. These patients were evaluated over 12 months from drug administration. The present study showed the continued long term efficacy over a period of 12 months follow up in these patients corroborating the result obtained in the previous phase II studies. There was significant improvement in rest pain, ankle systolic pressure, and ankle brachial pressure index with accelerated ulcer healing. In conclusion, the present study shows that the intramuscular administration of Stempeucel continues to be safe, tolerable, and effective alternative treatment in patients with Buerger's disease.
Journal of orthopaedic case reports · 2015
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Cureus · 2025 · Case Reports
Ghosh S, Vittobarao PG, S S, L A, et al.
Journal of orthopaedic case reports · 2025 · Case Reports
P JA, Shetty DK
Cureus · 2024 · Case Reports
Thavasianantham K, Raagul TS, Ganesh A, Elangovan P, et al.
Journal of neurosciences in rural practice · 2021 · Journal Article
Unni C, Pettakkandy V, P AJ, Soren SK, et al.
Journal of orthopaedic case reports · 2015 · Case Reports
Annappa R, Kotian P, P JA, Mudiganty S
Bioinformation · 2025 · Journal Article
V Pattar P, P VY, Jain N, Saha I, et al.
Biomedical physics & engineering express · 2025 · Journal Article
D K, D P, P V, G A, et al.
Journal of clinical orthopaedics and trauma · 2024 · Journal Article
Guarav P, Inuganti R, P R, Paleti ST
Cureus · 2023 · Journal Article
P A, Ingle V, Singhai A, Khadanga S, et al.
Journal of complementary & integrative medicine · 2024 · Journal Article
P AT, Deogade MS, Nesari TM, Ramachandran A
Journal of neurosciences in rural practice · 2021 · Journal Article
Unni C, Pettakkandy V, P AJ, Soren SK, et al.
Journal of orthopaedic case reports · 2015 · Case Reports
Annappa R, Kotian P, P JA, Mudiganty S
BMC rheumatology · 2020 · Journal Article
Sinha S, Ghosh B, Bandyopadhyay S, Fatima F, et al.
The Journal of the Association of Physicians of India · 2017 · Journal Article
Mathew AJ, Ganapati A, T SK, Goel R, et al.
Cureus · 2025 · Case Reports
Rijal S, Joshi A, P K
Current genomics · 2014 · Journal Article
J de AS, C A, P SG, S C
BMC rheumatology · 2020 · Journal Article
Sinha S, Ghosh B, Bandyopadhyay S, Fatima F, et al.
The Journal of arthroplasty · 2026 · Journal Article
Kashir I, Shanthanna H, Khanna V, Mbuagbaw L, et al.
Journal of complementary & integrative medicine · 2024 · Journal Article
P AT, Deogade MS, Nesari TM, Ramachandran A
Archives of osteoporosis · 2025 · Journal Article
N BV, A MS, A DR, H SG, et al.
Stem cells translational medicine · 2021 · Clinical Trial, Phase IV
Gupta PK, Dutta S, Kala S, Nekkanti M, et al.