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MME MONIQUE JUST

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Auteur de référence en rhumatologie
20 articles scientifiques publiés — un praticien à la pointe de la recherche

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Neurologic outcomes at school age in very preterm infants born with severe or mild growth restriction

Pediatrics · 2011

📚 143 citations🎯 RCR 5.81Top 6% NIH

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OBJECTIVE:To determine whether mild and severe growth restriction at birth among preterm infants is associated with neonatal mortality and cerebral palsy and cognitive performance at 5 years of age and school performance at 8 years of age.METHODS:All 2846 live births between 24 and 32 weeks' gestation from 9 regions in France in 1997 were included in a prospective observational study (the EPIPAGE [Étude Epidémiologique sur les Petits Ages Gestationnels] study) and followed until 8 years of age. Infants were classified as “small-for-gestational-age” (SGA) if their birth weight for gestational age was at the &lt;10th centile, “mildly-small-for-gestational-age” (M-SGA) if birth weight was at the ≥10th centile and &lt;20th centile, and “appropriate-for-gestational-age” (AGA) if birth weight was at the ≥20th centile.RESULTS:Among the children born between 24 and 28 weeks' gestation, the mortality rate increased from 30% in the AGA group to 42% in the M-SGA group and to 62% in the SGA group (P &lt; .01). Birth weight was not significantly associated with any cognitive, behavioral, or motor outcomes at the age of 5 or any school performance outcomes at 8 years. For the children born between 29 and 32 weeks' gestation, SGA children had a higher risk for mortality (adjusted odds ratio [aOR]: 2.79 [95% confidence interval (CI): 1.50–5.20]), minor cognitive difficulties (aOR: 1.73 [95% CI: 1.12–2.69]), inattention-hyperactivity symptoms (aOR: 1.78 [95% CI: 1.10–2.89]), and school difficulties (aOR: 1.74 [1.07–2.82]) compared with AGA children. Being born M-SGA was associated with an increased risk for minor cognitive difficulties (aOR: 1.87 [95% CI: 1.24–2.82]) and behavioral difficulties (aOR: 1.66 [95% CI: 1.04–2.62]).CONCLUSIONS:In preterm children, growth restriction was associated with mortality, cognitive and behavioral outcomes, as well as school difficulties.

Promoter hypermethylation: a common cause of reduced p16(INK4a) expression in uveal melanoma

Cancer research · 2001

📚 106 citations🎯 RCR 1.95

1. Lumbosacral radicular pain

Pain practice : the official journal of World Institute of Pain · 2024

📚 33 citations🎯 RCR 14.68Top 1% NIH🔓 Open Access📄 PDF gratuit ↗

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AbstractIntroductionPatients suffering lumbosacral radicular pain report radiating pain in one or more lumbar or sacral dermatomes. In the general population, low back pain with leg pain extending below the knee has an annual prevalence that varies from 9.9% to 25%.MethodsThe literature on the diagnosis and treatment of lumbosacral radicular pain was reviewed and summarized.ResultsAlthough a patient's history, the pain distribution pattern, and clinical examination may yield a presumptive diagnosis of lumbosacral radicular pain, additional clinical tests may be required. Medical imaging studies can demonstrate or exclude specific underlying pathologies and identify nerve root irritation, while selective diagnostic nerve root blocks can be used to confirm the affected level(s).In subacute lumbosacral radicular pain, transforaminal corticosteroid administration provides short‐term pain relief and improves mobility. In chronic lumbosacral radicular pain, pulsed radiofrequency (PRF) treatment adjacent to the spinal ganglion (DRG) can provide pain relief for a longer period in well‐selected patients. In cases of refractory pain, epidural adhesiolysis and spinal cord stimulation can be considered in experienced centers.ConclusionsThe diagnosis of lumbosacral radicular pain is based on a combination of history, clinical examination, and additional investigations. Epidural steroids can be considered for subacute lumbosacral radicular pain. In chronic lumbosacral radicular pain, PRF adjacent to the DRG is recommended. SCS and epidural adhesiolysis can be considered for cases of refractory pain in specialized centers.

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MME MONIQUE JUST

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Publications scientifiques (20) — classées par pathologie

Transversal17

Épidémiologie & registres1

Essai clinique1

Santé mentale / fatigue1

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