M FRANCOIS JEAN

Rhumatologue

RPPS 10000779339

📊 Reconnaissance scientifique : 128/100📝 822 articles publiés🇫🇷 Publications académiques françaises (8)

✨ Génération du profil synthétique IA en cours…

Activité de recherche & publications

Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.

Influence scientifique

128

128 articles ont été cités au moins 128fois par d'autres chercheurs — preuve que ses travaux sont repris par la communauté médicale.

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Articles de presse (16)

Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).

Pour le pape François, Jean Paul Ier demeure une référence - cath.ch

📰 cath.ch · 14/05/2026

<a href="https://news.google.com/rss/articles/CBMihgFBVV95cUxOd0YyYm5MU1FRdXhDTVlxYVdYeGZEb0hkWGd1OVFMT0VjMF9KYUtIMk9Da0hlcnZBUnpQdjNpaEpSVEd5UzhHc2EzNnJSQ2N3djIyN0h2UmU4WEZlVk1XRC1maEFtMzA2TTlFWjBhc1k0djItWUZxU08zVXhqOEF3bWVocmF2dw?oc=5" target="_blank">Pour le pape François, Jean Paul Ier demeure

Municipales 2026 : Découvrez la liste de Jean-Pierre Bouquet à Vitry-le-François - L'Union

📰 L'Union · 13/02/2026

<a href="https://news.google.com/rss/articles/CBMixAFBVV95cUxNelNkMXdMTTZRZGpSQmxEVmotUmtQbjNVaF9FU1pRb0xrLTZQVVUwZDhvNHZ0d2NsZGR5NktmSWZUNnE3RlcyTVotSDVVSlJ6NzhDU2sxaUUxOFpValdET2RiaTM0WHFFWUxrcDIzR01oZVliREFpcW1uQzFhRGIwQ09DeW1jeTdJMTNJSmZ5a2xZNnF5Q21iZUFtYmoycGdCMG00RGhmNWU4aEk1MVUzREU5aENBZVlfeU

Les voix de la santé se lèvent pour Gaza - L'Humanité

📰 L'Humanité · 19/09/2025

<a href="https://news.google.com/rss/articles/CBMihAFBVV95cUxOVnJwNm5KU2ZKTFkxME9fblNSajJoTDZaaXRkVGUxeGlkdExyUjhHSUNnVFlMekk3X3BGcXE1R2FZY0o1NFZzWW9wai1nNzFVSUNTazlZcng4SHJndVJGTjl1WUwyNTdydUVRdmVCSzFmMC1pQnloZmtheFNWR3I0RTFvb24?oc=5" target="_blank">Les voix de la santé se lèvent pour Gaza</a> <fo

SENS – Jean-François Ramon fait revivre l’héritage scientifique de son grand-père - L'independant de L'yonne -

📰 L'independant de L'yonne - · 01/03/2025

<a href="https://news.google.com/rss/articles/CBMisAFBVV95cUxPdnlpdWp4emdHWGpMS0tMd1NjcWFxYWxaXzhQdkVlVHRrUW9CR3ZxWUpHTlNxN2VaUGJnMldzZVpYMEpIaVZMZlpvYUUyaTdwX09saVpNbzV3RW9RVXBGM3ZzSkZFdk1ScWxBYkdGSm5GRU1JZmYyXzlsRG5Pak9fall1R004WmlhdHpCMmtOMTAzZHBOcEhkb0drRFYwSTFBemR3bE5JcTZpd3JhVFhIRA?oc=5" targe

Le maire de Vitry-le-François accompagne un ancien président de la République sur la Foire de Châlons - L'Union

📰 L'Union · 04/09/2025

<a href="https://news.google.com/rss/articles/CBMixgFBVV95cUxNSEktZ1VPNkpVcVNFdzdHZ2F4UzlsWl9jZFFzdU5xMWFnb1NYTzdJZjNmbnlIX285S2ZNY29fOVVIcmVoNmhEczJhOXl1R1pNMGlkUGUwaTd4SkV1YTZHdER4NUY5ZWpoY3VVUUxzR0FIaGJUQjdsTnpYamJ6MDVKTHR4NVM5RmRFWGozSTFJVi0zWmhoeUpXUXRxTzhIZVNTejhua3Q3bHZRY2F0dk1QTHlrNmxjNWNpTm

Patrick Timsit a-t-il un lien de parenté avec le médecin Jean-François Timsit ? Invités dans Quotidien, les deux hommes répondent - Voici

📰 Voici · 29/03/2021

<a href="https://news.google.com/rss/articles/CBMi-AFBVV95cUxQTUMyV2REbjZOQ05RUURBZUZTWU1rT2lnbEVJU2FFLTM1ckdGT1ZvajZtQW5lWTh0ZWZFOWZOaUhMeGlsenA3SW5YRnRzTVNodWhFS2ZLZVprWTdNSEExZ1dvdVp3M3MwWnB1MllOVGRrOGgydmRxOHFtWnFQbVJfYU8tY0llUXZfT3VyR0QyMUNwUGtaVzh0azJYLWFZY05ObzJEdU9kdi1rOEFnS1dVcWxZYTFBdXFWND

Le pape François, Jean-Marie Le Pen, Werenoi : les personnalités mortes en 2025 - Courrier picard

📰 Courrier picard · 22/12/2025

<a href="https://news.google.com/rss/articles/CBMizwFBVV95cUxOUC1NWGtNQmdqUzV4SzFYUG40WEllUzB6TUZObzBaUFEwSUkzdUxTVnRHbGY1bS1KdFlaejlidzBBYUx5RldMX24yd3FvZjJtWS1uQS1uMFUzZjNxZ3lINUVNZFZkTlFoRXFVenJlY1l0Y2VwLVpKSkFucFhEY1ZhNlhwN1dtbTBSbVlGeV9Ea3NMTmFNMk4wNmV2eVdheG5WaGZjUDhJTWxrcFJWMU1oejN1TVF5YVZrdj

Koh-Lanta : Géraldine, François, Jean-Charles et Bastien dans une finale à quatre sur les poteaux - CNews

📰 CNews · 20/06/2022

<a href="https://news.google.com/rss/articles/CBMitgFBVV95cUxONDFmUDZjQjE1elRLQkVGSERPNWc0aWhNci1wYklWNTJuS1RjajhqOEVsb0cydGlyRXFWbUpxdDUtZlhIaWRUSFdwWVhnNlRkcndPWW82ZGluR0hNcm1SbUdicW4yLWZ3Q0RBOTJBMFdxSmpFcDg0VHBURFNNVUhGdXFiMk1yR2RnamtuYmxNdm53NWFQbkdWYjZsakJlcGVrOHp3YU0zNzVMcXVGTTBwejMtekhjZ9IBuw

Plus belle la vie : Jean-François gravement malade ? - programme-tv.net

📰 programme-tv.net · 28/12/2015

<a href="https://news.google.com/rss/articles/CBMioAFBVV95cUxNa2J5ZmxjdjVVQURHUVRrQllWcXQ4SFdJRTkyWnMtaHZSTjdqVWpPOWZKdDlkQ1BuMmZ0WXRvaU1HNlh4VkFzOFdwNi1GUzltSnV0UV81ZXhYbVI5VTFWTzRQLURHZDQ1RzZQSFJXZEluMWt0R0dxUWszUWZtYVJlSW9hdVo3eXozSWFFakNUZ3IxdnBJaVdrc2VXM1VmR19D?oc=5" target="_blank">Plus belle

Nantes. Disparition de Jean-Claude Demaure, l’hommage de François Préneau - Ouest-France

📰 Ouest-France · 20/08/2016

<a href="https://news.google.com/rss/articles/CBMi-gFBVV95cUxQUnNDc2hjTmFUTG9icVRvbHlRaEFIS3FZcW5Mcmt6WU1JejJCdW1SZGJRS0dVMFZMbm1LTHdHc3FCaDVJOFA5by14eXFkdXJPamFjY041U3pIVkxoY2xFdGc3M0hZSnV3QkZaTFJYVE9VOFdEcFFaZEJkTHk0VEh1cG5mRHl1eFZkNkFaX1o5VmlCTWFzQW9ubnptbGMtRmI0dWczSk5wRjg0anlBdC1WOVFWU2N0YWlLRk

Koh-Lanta : Vilaine blessure pour Jean-Charles… à cause d’un bambou (VIDEO) - Télé 7 Jours

📰 Télé 7 Jours · 09/03/2022

<a href="https://news.google.com/rss/articles/CBMi0AFBVV95cUxNcWFlemRwRHh0T01rS1JOY3B4eVJ2STJfNDdiQ0dsTE9jV3FhZjNJVnBaaTFZam5KOGoxWENHV0hxc1RXRjItNzJyblV3Mmk0NEVfTDkwc1A3Q3V3T1JHN2d4TFJWMVhVbmN6UXg2aU45cDNMN1BWNmx1YmdRMTBtbTltV0x1VWdkTV9QX1dJTGMwUDM4ZWx4N095bG1SV3Y1V1BwWkdiQXZfMTRPR09yUHozTlk5dmlYNn

Mort de Jean-Louis Debré : l’ancien ministre de l’intérieur est mort à l’âge de 80 ans - L'Indépendant

📰 L'Indépendant · 04/03/2025

<a href="https://news.google.com/rss/articles/CBMizgFBVV95cUxPZF9HcThUYkR1YnFfQ3BqNGhYSFFRVlFRRXhjREpocl9KQVk0SW5pLTdzWEE4NjZ3Z1BxbTMtVWdDVUU0eVQtWGdqeTkyNkwyVjVsS2J6YjBteTFtTHl6VmNZbXF2RS1lOGtNUlBkckxFVVhmVFFUOF9zQm1mR3M0emlPZEt5MS1EZ0kwbWtnLUlwRThZdDZ4R2EyZlNuckx0N1BYS2RaQl9GNGtXckE4LWM5RE9WZURBUV

Top publications · les plus citées

Advancing digital health equity: Directions for behavioral and social science research

Translational behavioral medicine · 2023

📚 43 citations🎯 RCR 7.77Top 4% NIH🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

Abstract The field of digital health is evolving rapidly and encompasses a wide range of complex and changing technologies used to support individual and population health. The COVID-19 pandemic has augmented digital health expansion and significantly changed how digital health technologies are used. To ensure that these technologies do not create or exacerbate existing health disparities, a multi-pronged and comprehensive research approach is needed. In this commentary, we outline five recommendations for behavioral and social science researchers that are critical to promoting digital health equity. These recommendations include: (i) centering equity in research teams and theoretical approaches, (ii) focusing on issues of digital health literacy and engagement, (iii) using methods that elevate perspectives and needs of underserved populations, (iv) ensuring ethical approaches for collecting and using digital health data, and (v) developing strategies for integrating digital health tools within and across systems and settings. Taken together, these recommendations can help advance the science of digital health equity and justice.

Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn's disease

Gut · 2023

📚 36 citations🎯 RCR 3.64Top 12% NIH🔓 Open Access

Lire l'abstract Crossref ↓

Objective Intestinal barrier loss is a Crohn’s disease (CD) risk factor. This may be related to increased expression and enzymatic activation of myosin light chain kinase 1 (MLCK1), which increases intestinal paracellular permeability and correlates with CD severity. Moreover, preclinical studies have shown that MLCK1 recruitment to cell junctions is required for tumour necrosis factor (TNF)-induced barrier loss as well as experimental inflammatory bowel disease progression. We sought to define mechanisms of MLCK1 recruitment and to target this process pharmacologically. Design Protein interactions between FK506 binding protein 8 (FKBP8) and MLCK1 were assessed in vitro. Transgenic and knockout intestinal epithelial cell lines, human intestinal organoids, and mice were used as preclinical models. Discoveries were validated in biopsies from patients with CD and control subjects. Results MLCK1 interacted specifically with the tacrolimus-binding FKBP8 PPI domain. Knockout or dominant negative FKBP8 expression prevented TNF-induced MLCK1 recruitment and barrier loss in vitro. MLCK1-FKBP8 binding was blocked by tacrolimus, which reversed TNF-induced MLCK1-FKBP8 interactions, MLCK1 recruitment and barrier loss in vitro and in vivo. Biopsies of patient with CD demonstrated increased numbers of MLCK1-FKBP8 interactions at intercellular junctions relative to control subjects. Conclusion Binding to FKBP8, which can be blocked by tacrolimus, is required for MLCK1 recruitment to intercellular junctions and downstream events leading to immune-mediated barrier loss. The observed increases in MLCK1 activity, MLCK1 localisation at cell junctions and perijunctional MLCK1-FKBP8 interactions in CD suggest that targeting this process may be therapeutic in human disease. These new insights into mechanisms of disease-associated barrier loss provide a critical foundation for therapeutic exploitation of FKBP8-MLCK1 interactions.

Longitudinal impact of the COVID19 pandemic on mental health in a general population sample in France: Evidence from the COMET Study

Journal of affective disorders · 2023

📚 18 citations🎯 RCR 3.33Top 14% NIH🔓 Open Access

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Articles de presse (16)

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Publications scientifiques (18) — classées par pathologie

Transversal8

Santé mentale / fatigue4

Essai clinique2

Génétique1

IRM ostéo-articulaire1

Lombalgie1

Pédiatrie1

Pharmacovigilance1

Revue générale1

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