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M CLAUDE HONTAREDE

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Auteur de référence en rhumatologie
29 articles scientifiques publiés — un praticien à la pointe de la recherche

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Top publications · les plus citées

Re-assessment of the risks to public health related to the genotoxicity of styrene present in plastic food contact materials

EFSA journal. European Food Safety Authority · 2025

📚 3 citations🔓 Open Access

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Abstract The EFSA Panel on Food Contact Materials (FCM) was requested by the European Commission to re‐evaluate the potential genotoxicity of styrene after oral exposure and its safety for use in plastic FCM with a specific migration limit (SML) of 40 μg/kg food. A rigorous assessment of the in vivo genotoxicity studies (i) provided by third parties, (ii) identified by a targeted literature search and (iii) reported in the 2019 IARC Monograph was performed. All studies were assessed for reliability and relevance and the results integrated in the weight of evidence. The results provided by reliable in vivo oral genotoxicity studies, covering different genetic endpoints and target tissues, including liver, the primary site of metabolism, demonstrated that the oral administration of styrene in mice and rats up to the maximum tolerated dose (300 and 500 mg/kg body weight (bw), respectively) did not induce genotoxic effects. The Panel concluded that there was no evidence that styrene is genotoxic following oral exposure. For substances demonstrated to be non‐genotoxic, according to the EFSA Note for Guidance for FCM, an SML up to 50 μg/kg food would not be of safety concern. Consequently, the use of styrene in the manufacture of FCM respecting the SML of 40 μg/kg food proposed by the European Commission is not of safety concern.

Patient safety culture in the operating room of African hospitals: a systematic review

Patient safety in surgery · 2026

📚 1 citations🔓 Open Access

Endocrine care of transgender and gender-diverse adults: Swiss recommendations

Swiss medical weekly · 2026

📚 1 citations🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

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Transgender and gender-diverse individuals require standardised, evidence-based and culturally sensitive endocrine care. International guidelines such as those from the World Professional Association for Transgender Health (WPATH) and the Endocrine Society provide a strong foundation. These Swiss recommendations build on them and offer context-specific recommendations adapted to Switzerland’s healthcare system, insurance policies and social considerations. These recommendations were developed by the “Working Group Transgender” of the Swiss Society of Endocrinology and Diabetology (SSED/SGED) in collaboration with multidisciplinary experts. They primarily focus on gender-affirming hormone therapy, including indications, monitoring and long-term management. They also address fertility preservation, bone and sexual health, and relevant psychological and legal aspects. Interdisciplinary collaboration among endocrinologists, primary care providers, mental health professionals, reproductive specialists and surgeons is recommended to ensure cohesive patient-centred care.

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M CLAUDE HONTAREDE

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Top publications · les plus citées

Publications scientifiques (29) — classées par pathologie

Transversal10

Pédiatrie4

Pharmacovigilance4

Revue générale3

Génétique2

Biothérapies non-anti-TNF1

Case report / série1

Épidémiologie & registres1

Essai clinique1

Lupus1

Revue / méta-analyse1

SAPL1

Vascularites des gros vaisseaux1

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