📇 Rhumatologue · GAILLON · (27) · Libéral
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3 raisons identifiées
Praticien-chercheur
10 articles scientifiques publiés — formation continue solide
Référence presse grand public
Cité 1 fois dans les médias — pédagogie reconnue
Délais de RDV courts dans la région
63.9 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
CABINET DU DR MALIKA HARDY
3 RUE ROLAND ROCHE, 27600 GAILLON
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📰 Actu.fr · 13/02/2023
<a href="https://news.google.com/rss/articles/CBMi0gFBVV95cUxORG9QanN6Tks5RTVvTW1IWlJfQjR5Z0lRSkZRby1Vb1Z0LXBkdlJUaEEwblJ6M281dHU5cWRDdlE4UzhxZVAxMGlSek5aZDU2U0tiWklaYTZHUVltdVRaR1RMU3p2Z2NtUDdfMEFLWEV5M3FhYXgxOUFwNkNWWXJNN0p5VThsb0FxejBCRjVRTkxBRy1hS3ViWTlJX0FFeGR3ZjVua3NmWXBKZ2xVd1JaeWtIOUdqblNVbW
Arthritis and rheumatism · 2002
AbstractObjectiveTo examine cyclooxygenase‐2 (COX‐2) enzyme expression, its regulation by interleukin‐1β (IL‐1β), and the role of prostaglandin E2 (PGE2) in proteoglycan degradation in human osteoarthritic (OA) cartilage.MethodsSamples of human OA articular cartilage, meniscus, synovial membrane, and osteophytic fibrocartilage were obtained at knee arthroplasty and cultured ex vivo with or without IL‐1β and COX inhibitors. COX expression was evaluated by immunohistochemistry and Western blot analysis. The enzymatic activity of COX was measured by conversion of arachidonic acid to PGE2. Cartilage degradation was evaluated by measuring the accumulation of sulfated glycosaminoglycans in the medium.ResultsIL‐1β induced robust expression of COX‐2 and PGE2 in OA meniscus, synovial membrane, and osteophytic fibrocartilage explants, whereas low levels were produced in OA articular cartilage. IL‐1β also induced cartilage proteoglycan degradation in OA synovial membrane‐cartilage cocultures. Increased proteoglycan degradation corresponded to the induction of COX‐2 protein expression in, and PGE2 production from, the synovial membrane. Dexamethasone, neutralizing IL‐1β antibody, or the selective COX‐2 inhibitor, SC‐236, attenuated both the IL‐1β‐induced PGE2 production and cartilage proteoglycan degradation in these cocultures. The addition of PGE2 reversed the inhibition of proteoglycan degradation caused by SC‐236.ConclusionIL‐1β‐induced production of COX‐2 protein and PGE2 was low in OA articular cartilage compared with that in the other OA tissues examined. IL‐1β‐mediated degradation of cartilage proteoglycans in OA synovial membrane‐cartilage cocultures was blocked by the selective COX‐2 inhibitor, SC‐236, and the effect of SC‐236 was reversed by the addition of exogenous PGE2. Our data suggest that induction of synovial COX‐2‐produced PGE2 is one mechanism by which IL‐1β modulates cartilage proteoglycan degradation in OA.
Advances in experimental medicine and biology · 2002
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Research and practice in thrombosis and haemostasis · 2024 · Journal Article
Hardy M, Catry E, Pouplard M, Lecompte T, et al.
The Medical journal of Australia · 2022 · Letter
Oliver J, Hardy M, Osowicki J, Engelman D, et al.
Journal of clinical medicine · 2022 · Journal Article
Lardinois B, Hardy M, Michaux I, Horlait G, et al.
International journal of molecular sciences · 2021 · Journal Article
Stone RN, Frahs SM, Hardy MJ, Fujimoto A, et al.
Arthritis and rheumatism · 2002 · Comparative Study
Hardy MM, Seibert K, Manning PT, Currie MG, et al.
Advances in experimental medicine and biology · 2002 · Journal Article
Koki A, Khan NK, Woerner BM, Dannenberg AJ, et al.
Journal of paediatrics and child health · 2020 · Journal Article
Oliver J, Osowicki J, Cordell B, Hardy M, et al.
Nature · 2010 · Journal Article
Wellcome Trust Case Control Consortium, Craddock N, Hurles ME, Cardin N, et al.
Journal of paediatrics and child health · 2023 · Journal Article
Lindholm DE, Whiteman IJ, Oliver J, Cheung MMH, et al.
Evidence report/technology assessment (Summary) · 2003 · Journal Article
Hardy ML, Coulter I, Morton SC, Favreau J, et al.