📇 Rhumatologue ·

M BRUNO GUIARD

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4 raisons identifiées

Auteur de référence en rhumatologie
50 articles scientifiques publiés — un praticien à la pointe de la recherche
Encadrant universitaire
Forme la prochaine génération de rhumatologues (6 thèses dirigées)
Référence presse grand public
Cité 4 fois dans les médias — pédagogie reconnue
Expérience confirmée
21 ans d'exercice en rhumatologie — recul clinique solide

Rhumatologue

RPPS 10000735174

EnseignementExpérience confirmée

21ans d'exercice (thèse 2005)

📊 Reconnaissance scientifique : 42/100📝 157 articles publiés🇫🇷 Publications académiques françaises (8)🎓 6 thèses dirigées

✨ Génération du profil synthétique IA en cours…

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

The menace of obesity to depression and anxiety prevalence

Trends in endocrinology and metabolism: TEM · 2022

📚 282 citations🎯 RCR 30.49Top 0% NIH🔓 Open Access📄 PDF gratuit ↗

High-fat diet-induced metabolic disorders impairs 5-HT function and anxiety-like behavior in mice

British journal of pharmacology · 2016

📚 135 citations🎯 RCR 6.15Top 6% NIH🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

Background and PurposeThe link between type 2 diabetes mellitus (T2DM) and depression is bidirectional. However, the possibility that metabolic disorders may elicit anxiogenic‐like/depressive‐like symptoms or alter the efficacy of antidepressant drugs remains poorly documented. This study explored the influence of T2DM on emotionality and proposed a therapeutic strategy that might be used in depressed diabetic patients.Experimental ApproachMice were fed a high‐fat diet (HFD) and subjected to a full comprehensive metabolic and behavioural analysis to establish correlations between metabolic and psychiatric disorders. In vivo intra‐hippocampal microdialysis was also applied to propose a mechanism underpinning the phenotype of mice fed the HFD. Finally, we tested whether chronic administration of the selective 5‐HT reuptake inhibitor escitalopram or HFD withdrawal could reverse HFD‐induced metabolic and behavioural anomalies.Key ResultsThe increased body weight, hyperglycaemia and impaired glucose tolerance in response to HFD were correlated with anxiogenic‐like/depressive‐like symptoms. Moreover, this phenotype was associated with decreased extracellular 5‐HT levels in the hippocampus which may result from increased sensitivity of the dorsal raphe 5‐HT1A autoreceptor. Interestingly, the beneficial effect of prolonged administration of escitalopram was abolished in HFD‐fed mice. On the contrary, HFD withdrawal completely reversed metabolic impairments and positively changed symptoms of anxiety, although some behavioural anomalies persisted.Conclusions and ImplicationsOur data provide clear‐cut evidence that both pathologies are finely correlated and associated with impaired 5‐HT mediated neurotransmission in the hippocampus. Further experiments are warranted to define the most adequate strategy for the treatment of such co‐morbidity.Linked ArticlesThis article is part of a themed section on Updating Neuropathology and Neuropharmacology of Monoaminergic Systems. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v173.13/issuetoc

Metformin Promotes Anxiolytic and Antidepressant-Like Responses in Insulin-Resistant Mice by Decreasing Circulating Branched-Chain Amino Acids

The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019

📚 112 citations🎯 RCR 5.86Top 6% NIH🔓 Open Access📄 PDF gratuit ↗

Cookies & analyse de trafic

M BRUNO GUIARD

Pourquoi vous devez consulter ce praticien

Thèses universitaires

Direction de thèses

Activité de recherche & publications

Publications académiques en France

Lieu de consultation

Tarifs & secteur de conventionnement

Prendre rendez-vous & contact

Articles de presse (4)

Top publications · les plus citées

Publications scientifiques (50) — classées par pathologie

Transversal41

Santé mentale / fatigue5

Génétique2

Activité physique / Rééducation1

Épidémiologie & registres1

Revue générale1

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