M ALAIN GUERIN

Rhumatologue

RPPS 10000759349

📊 Reconnaissance scientifique : 53/100📝 150 articles publiés🇫🇷 Publications académiques françaises (8)

✨ Génération du profil synthétique IA en cours…

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Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.

Influence scientifique

53 articles ont été cités au moins 53fois par d'autres chercheurs — preuve que ses travaux sont repris par la communauté médicale.

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Top publications · les plus citées

Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2003

📚 1449 citations🎯 RCR 37.07Top 0% NIH

Central pulse pressure and mortality in end-stage renal disease

Hypertension (Dallas, Tex. : 1979) · 2002

📚 612 citations🎯 RCR 15.85Top 1% NIH🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

Damage of large arteries is a major factor in the high cardiovascular morbidity and mortality of patients with end-stage renal disease (ESRD). Increased aortic pulse wave velocity (PWV) and brachial pulse pressure (PP) are the principal arterial markers of cardiovascular mortality described in these patients. Whether central (carotid) PP and brachial-carotid PP amplification may predict all-cause (including cardiovascular) mortality has never been investigated. A cohort of 180 patients with ESRD who were undergoing hemodialysis was studied between January 1990 and March 2000. The mean duration of follow-up was 52±36 months (mean±SD). Mean age at entry was 51.5±16.3 years. Seventy deaths occurred, including both cardiovascular and noncardiovascular fatal events. At entry, patients underwent carotid PP measurements (pulse wave analysis), echocardiography, and aortic PWV (Doppler ultrasonography), together with standard clinical and biochemical analyses. On the basis of Cox analyses, after adjustment of age, time on dialysis before inclusion, and previous cardiovascular events, 3 factors emerged as predictors of all-cause mortality: carotid PP, brachial/carotid PP, and aortic PWV. Adjusted hazard ratios for 1-SD increments were 1.4 (1.1 to 1.8) for carotid PP, 0.5 (0.3 to 0.8) for brachial/carotid PP, and 1.3 (1.0 to 1.7) for PWV. Brachial blood pressure, including PP, had no predictive value for mortality after adjustment. These results provide the first direct evidence that in patients with ESRD, the carotid PP level and, mostly, the disappearance of PP amplification are strong independent predictors of all-cause (including cardiovascular) mortality.

Arterial calcifications and bone histomorphometry in end-stage renal disease

Journal of the American Society of Nephrology : JASN · 2004

📚 434 citations🎯 RCR 12.90Top 2% NIH

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M ALAIN GUERIN

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Activité de recherche & publications

Publications académiques en France

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Articles de presse (2)

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Publications scientifiques (36) — classées par pathologie

Transversal23

Risque cardio-vasculaire4

Anti-TNF2

Épidémiologie & registres2

Goutte2

Économie santé1

Lupus1

Sclérodermie1

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