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M JACQUES GLETTY

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Auteur de référence en rhumatologie
26 articles scientifiques publiés — un praticien à la pointe de la recherche

Rhumatologue

RPPS 10002100385

✨ Génération du profil synthétique IA en cours…

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Top publications · les plus citées

EUS-Guided Liver Biopsy and Portal Pressure Measurement Compared With a Transjugular Approach: A Randomized Controlled Trial

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026

📚 3 citations

Prophylactic clipping after colorectal endoscopic submucosal dissection in randomized controlled trials: a systematic review and meta-analysis

Endoscopy · 2026

📚 1 citations🩺 Clinique

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Abstract Endoscopic submucosal dissection (ESD) is a minimally invasive and effective treatment for large nonpedunculated colorectal polyps; however, it carries a relevant risk of adverse events (AEs), such as delayed bleeding, as well as postprocedural perforation (PPP) and postelectrocoagulation syndrome (PECS). Systematic defect closure may reduce these risks, but its preventive efficacy remains uncertain. We conducted a meta-analysis of randomized controlled trials (RCTs) to assess the efficacy of prophylactic clipping after colorectal ESD. Following PRISMA guidelines, we searched MEDLINE, Embase, and SCOPUS through to June 2025 for RCTs comparing prophylactic clipping vs. no clipping after colorectal ESD in adults. The primary outcome was clinically significant delayed bleeding; secondary outcomes included PPP and PECS, as well as subanalysis by location and size. Random-effects models were used to compute risk ratios (RRs) and 95%CIs. Four RCTs from Asia including 684 patients were analyzed (336 with clipping, 348 controls). Prophylactic clipping significantly reduced clinically significant delayed bleeding risk (0.3% vs. 3.4%; RR 0.26, 95%CI 0.08–0.88). No significant differences were found for PPP (0.4% vs. 1.0%; RR 0.74; 95%CI 0.23–2.35) or PECS (12.2% vs. 11.8%; RR 1.06; 95%CI 0.74–1.52). Subgroup analyses by lesion size (>30 mm vs. <30 mm) and location (proximal vs. distal colon) were not significant. A 74% decrease in the risk of clinically significant delayed bleeding is achieved by prophylactic clipping after colorectal ESD, supporting its adoption in routine practice.

Suicidal Behavior in Mild Cognitive Impairment and Dementia in the Old Adults: A Systematic Review and Meta-Analysis

Journal of geriatric psychiatry and neurology · 2026

📚 1 citations🔓 Open Access

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Objectives To address the prevalence and risk factors of suicidal outcomes in people with mild cognitive impairment or dementia. Methods Four databases were searched for studies reporting data on the prevalence or the risk of a suicidal event, in people with a clinical diagnosis of MCI or dementia. The research was conducted according to PRISMA guidelines. A narrative synthesis was used to report the main findings. A random effect model was used across all analyses to calculate the prevalence and the odds ratio of suicidal outcomes in people with dementia. Results Fifty-nine studies were included. The pooled prevalence of suicidal outcomes in people with dementia were as follows: suicidal ideation: 9.7% (95%CI 6.7-13.9), suicide attempt: 0.8% (95%CI 0.3-2.4), and suicidal death: 0.2% (95%CI 0.1-0.4). People with dementia had an increased risk of suicidal ideation (OR 1.87, 95%CI 1.21-2.88) and suicide attempt (OR 2.4, 95%CI 1.24-4.65) but no significant increase in the risk of suicidal death. The heterogeneity was high for each outcome. The risk factors for suicidal death in dementia were younger age, recent diagnosis, previous mental health disorder, and frontotemporal dementia. The prevalence of suicidal ideation in MCI ranged from 5 to 17.6%, with a moderate increase in suicide attempts (HR 1.34, 95%CI 1.09-1.65) and no increase in suicidal death. Conclusions People with dementia frequently have suicidal thoughts and are at an increased risk of suicide attempts. Clinicians should be careful to identify those at higher risk in order to offer them supportive care and restrict their access to lethal means.

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M JACQUES GLETTY

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Top publications · les plus citées

Publications scientifiques (26) — classées par pathologie

Transversal8

Revue / méta-analyse6

Revue générale6

Essai clinique5

Pédiatrie3

Économie santé1

Épidémiologie & registres1

Gériatrie1

Pharmacovigilance1

Santé mentale / fatigue1

Vraie vie / RWE1

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