📇 Rhumatologue ·

M Philippe GIRAL

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3 raisons identifiées

Auteur de référence en rhumatologie
50 articles scientifiques publiés — un praticien à la pointe de la recherche
Encadrant universitaire
Forme la prochaine génération de rhumatologues (1 thèse dirigée)
Référence presse grand public
Cité 7 fois dans les médias — pédagogie reconnue

Rhumatologue

RPPS 10000390608

📊 Reconnaissance scientifique : 60/100📝 294 articles publiés🇫🇷 Publications académiques françaises (8)🎓 1 thèse dirigée

✨ Génération du profil synthétique IA en cours…

Direction de thèses

🎓 1 thèse dirigée

Implication des phagocytes mononucléés dans les pathologies inflammatoires chroniques : exploration d’un modèle murin d’athérosclérose et du xanthogranulome chez l’homme

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Articles de presse (7)

Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).

Le taux de cholestérol varie avec les saisons - Doctissimo

📰 Doctissimo · 15/11/2022

<a href="https://news.google.com/rss/articles/CBMingFBVV95cUxQdXVGUllLNGx5OWw3dkZnYWFqR1FtOENnczFldDVnYktIbkhHNlZvWnBqV0xvbEFQNk5kdzROVHBnT1RRMjRpZVJXQ0lGWEg5aGplXzZEVkxBN1pXRTJKaXctLUtJcnRYSnlzdmNiT2YydFFqY014dEk4d1VuYTAwUDluUVA2V3FhSW1LU2N3VUdLZUZQM3RkYlI4TjVIUQ?oc=5" target="_blank">Le taux de ch

Quel gras consommer cet été ? - The Conversation

📰 The Conversation · 30/06/2021

<a href="https://news.google.com/rss/articles/CBMib0FVX3lxTFB1Q05XLXBlWVdpTlJwaFVHZVlzcVBlcUJ3a0xUNWhYMDR5X3VDNkR2a1pSYTBiQzlSWDVqOFpkQVhfY0tibU1xRVlGSWNnT2Q1RUl2VjZCVWE3a0haZTBQZThwOVdxcHVaNUEwRFJJWQ?oc=5" target="_blank">Quel gras consommer cet été ?</a> <font color="#6f6f6f">The Conversation</fon

Sur YouTube, les médecins des hôpitaux de Paris ont leur émission de santé - Le Parisien

📰 Le Parisien · 28/11/2019

<a href="https://news.google.com/rss/articles/CBMi0gFBVV95cUxOazB4OV9ieHdBeElfdDJsUjlsU3BzajljOWJPT01yZmxWQjZkY3d3R0hlMXE0QjlCNnRaSDFROVV1QXVqSzJRd3VSQ2YwQ3dsNHZRbzl0UWlGdndsUHlOVlhsckgwMnZYTmt2YXNraTM2bVB3WldXYkhwN2VjbTBvbTJFWVNjeHFnWk8wV3FHSVFSVzNyVEhZX2llSWJzM2hna3RXSWF2OXA5N1Z5bk5ZNzNIRl8tWVFoYU

Statines : l’arrêt du traitement passé 75 ans augmente le risque cardiovasculaire. - Santé Magazine

📰 Santé Magazine · 02/08/2019

<a href="https://news.google.com/rss/articles/CBMizwFBVV95cUxNeFBRd2kzM25VMjhKOEM1dUJiSTdIR1ZHOVllaGg1VUY2ZXdWbDU5eVdnUjIwRVlNX1FSbkpZUDNMdFlJQTlLRjdRYjlZbzZzUFpRaDIyQ3J0TnZCc2VSMzBRZy1xZnA5ZFhkenh5eGNCUFZ3T1pCSkRsaklhcjhxM0pjU0Yyc2JVOE1EYk5BLXVNaWJUQmttUm9QYW5CdVk3cDc3NDFJdEllVU9kMGRDc252djVPZDNUVG

Deux pommes par jour éloignent le médecin ! - Allo Docteurs

📰 Allo Docteurs · 12/10/2012

<a href="https://news.google.com/rss/articles/CBMikgFBVV95cUxPam1zUm50cFUtWW45LW1Fak1jb0VwYlNYZkNzWlR6UjZBejFpN2R3YmZuVGIzSTMybW1hdHNiVzY5bms4SWRDQm5Gdk9kcHNWVE1nVnY4ZDlKSXp2d1YxWTN4ZGk3bmI0RHFKdTl6OFBTd3paWW1GLUFmZEJ3UzNUaTM2LTYzejlWYkRYYXF1eE15dw?oc=5" target="_blank">Deux pommes par jour éloignen

Cholestérol : les analyses ? - Allo Docteurs

📰 Allo Docteurs · 29/05/2011

<a href="https://news.google.com/rss/articles/CBMie0FVX3lxTE8ySk5fMXVvclV5eUwzNk9hWHVGMUVmZHZMczJra25kMWlKSG16QVoxMUNHNHc5ZGpPc1VyazJqN2FkY2RkbUxad3hwdm42RXM0Y0lRQ1NRU1RLRTcwQmptRnl3SzNkX1FtUVpnS1ZjRGxFdFFtV1Jua2xZOA?oc=5" target="_blank">Cholestérol : les analyses ?</a> <font color="#6f6f6f">Allo D

Ch@t : Le cholestérol - Allo Docteurs

📰 Allo Docteurs · 15/05/2011

<a href="https://news.google.com/rss/articles/CBMipgFBVV95cUxPQkV6Sl9xSDVIMTJVY0c4Z3NxRHNNMndfQmFZakRJc3VzaHZVQ2VhMlhsNXZFYnFabFVqTHBma3ZHelRYTUlmWHctbFp1d3FYRm1YUGZkdi1FTU1pMDNURUExZmJxWU5tVk05RThrdXlLS0h5eUEtRFFnQXFWR2lEYWtrX0FzcVVRS2pfY3VoVnY0NFdUeGlGbVpEM2NqRmFDOUZxd2tn?oc=5" target="_blank">Ch@

Top publications · les plus citées

The intestinal microbiota regulates host cholesterol homeostasis

BMC biology · 2019

📚 159 citations🎯 RCR 7.54Top 4% NIH🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

AbstractBackgroundManagement of blood cholesterol is a major focus of efforts to prevent cardiovascular diseases. The objective of this study was to investigate how the gut microbiota affects host cholesterol homeostasis at the organism scale.ResultsWe depleted the intestinal microbiota of hypercholesterolemic femaleApoe−/−mice using broad-spectrum antibiotics. Measurement of plasma cholesterol levels as well as cholesterol synthesis and fluxes by complementary approaches showed that the intestinal microbiota strongly regulates plasma cholesterol level, hepatic cholesterol synthesis, and enterohepatic circulation. Moreover, transplant of the microbiota from humans harboring elevated plasma cholesterol levels to recipient mice induced a phenotype of high plasma cholesterol levels in association with a low hepatic cholesterol synthesis and high intestinal absorption pattern. Recipient mice phenotypes correlated with several specific bacterial phylotypes affiliated toBetaproteobacteria,Alistipes,Bacteroides, andBarnesiellataxa.ConclusionsThese results indicate that the intestinal microbiota determines the circulating cholesterol level and may thus represent a novel therapeutic target in the management of dyslipidemia and cardiovascular diseases.

Cardiovascular effect of discontinuing statins for primary prevention at the age of 75 years: a nationwide population-based cohort study in France

European heart journal · 2019

📚 115 citations🎯 RCR 5.34Top 7% NIH🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

Abstract Aims The role of statin therapy in primary prevention of cardiovascular disease in persons older than 75 years remains a subject of debate with little evidence to support or exclude the benefit of this treatment. We assessed the effect of statin discontinuation on cardiovascular outcomes in previously adherent 75-year-olds treated for primary prevention. Methods and results A population-based cohort study using French national healthcare databases was performed, studying all subjects who turned 75 in 2012–14, with no history of cardiovascular disease and with a statin medication possession ratio ≥80% in each of the previous 2 years. Statin discontinuation was defined as three consecutive months without exposure. The outcome was hospital admission for cardiovascular event. The hazard ratio comparing statin discontinuation with continuation was estimated using a marginal structural model adjusting for both baseline and time-varying covariates (cardiovascular drug use, comorbidities, and frailty indicators). A total of 120 173 subjects were followed for an average of 2.4 years, of whom 17 204 (14.3%) discontinued statins and 5396 (4.5%) were admitted for a cardiovascular event. The adjusted hazard ratios for statin discontinuation were 1.33 [95% confidence interval (CI) 1.18–1.50] (any cardiovascular event), 1.46 (95% CI 1.21–1.75) (coronary event), 1.26 (95% CI 1.05–1.51) (cerebrovascular event), and 1.02 (95% CI 0.74–1.40) (other vascular event). Conclusion Statin discontinuation was associated with a 33% increased risk of admission for cardiovascular event in 75-year-old primary prevention patients. Future studies, including randomized studies, are needed to confirm these findings and support updating and clarification of guidelines on the use of statins for primary prevention in the elderly.

Free cholesterol transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis underlies the U-shape relationship between HDL-cholesterol and cardiovascular disease

European journal of preventive cardiology · 2020

📚 69 citations🎯 RCR 4.11Top 10% NIH🔓 Open Access

Lire l'abstract Crossref ↓

BackgroundLow concentrations of high-density lipoprotein cholesterol (HDL-C) represent a well-established cardiovascular risk factor. Paradoxically, extremely high HDL-C levels are equally associated with elevated cardiovascular risk, resulting in the U-shape relationship of HDL-C with cardiovascular disease. Mechanisms underlying this association are presently unknown. We hypothesised that the capacity of high-density lipoprotein (HDL) to acquire free cholesterol upon triglyceride-rich lipoprotein (TGRL) lipolysis by lipoprotein lipase underlies the non-linear relationship between HDL-C and cardiovascular risk.MethodsTo assess our hypothesis, we developed a novel assay to evaluate the capacity of HDL to acquire free cholesterol (as fluorescent TopFluor® cholesterol) from TGRL upon in vitro lipolysis by lipoprotein lipase.ResultsWhen the assay was applied to several populations markedly differing in plasma HDL-C levels, transfer of free cholesterol was significantly decreased in low HDL-C patients with acute myocardial infarction (−45%) and type 2 diabetes (–25%), and in subjects with extremely high HDL-C of >2.59 mmol/L (>100 mg/dL) (−20%) versus healthy normolipidaemic controls. When these data were combined and plotted against HDL-C concentrations, an inverse U-shape relationship was observed. Consistent with these findings, animal studies revealed that the capacity of HDL to acquire cholesterol upon lipolysis was reduced in low HDL-C apolipoprotein A-I knock-out mice and was negatively correlated with aortic accumulation of [3H]-cholesterol after oral gavage, attesting this functional characteristic as a negative metric of postprandial atherosclerosis.ConclusionsFree cholesterol transfer to HDL upon TGRL lipolysis may underlie the U-shape relationship between HDL-C and cardiovascular disease, linking HDL-C to triglyceride metabolism and atherosclerosis.

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M Philippe GIRAL

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Direction de thèses

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Publications académiques en France

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Articles de presse (7)

Top publications · les plus citées

Publications scientifiques (50) — classées par pathologie

Transversal24

Risque cardio-vasculaire11

Génétique5

Épidémiologie & registres3

Économie santé2

Essai clinique2

IRM ostéo-articulaire1

Microbiote1

Pharmacovigilance1

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