Chargement de la fiche…
Chargement de la fiche…
MonRhumato.fr utilise des cookies pour mesurer l'audience (statistiques) et améliorer le site. Aucune donnée de santé identifiable n'est jamais collectée. Politique de confidentialité.
Votre choix est conservé 13 mois (durée max CNIL). Vous pouvez le modifier à tout moment via Préférences cookies.
3 raisons identifiées
Auteur de référence en rhumatologie
50 articles scientifiques publiés — un praticien à la pointe de la recherche
Encadrant universitaire
Forme la prochaine génération de rhumatologues (1 thèse dirigée)
Référence presse grand public
Cité 7 fois dans les médias — pédagogie reconnue
✨ Génération du profil synthétique IA en cours…
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Doctorant·e : John Pirault
Source theses.fr — signal de direction d'équipe / statut PU-PH (à confirmer via le site universitaire).
Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.
Influence scientifique
60
60 articles ont été cités au moins 60fois par d'autres chercheurs — preuve que ses travaux sont repris par la communauté médicale.
h-index
Total citations reçues
15 450
Nombre de fois où d'autres équipes ont mentionné ses publications dans leurs propres travaux.
Publications totales
294
Articles, revues et chapitres référencés dans les bases académiques internationales.
Articles influents
154
Publications ayant marqué leur domaine — chacune citée au moins 10 fois par d'autres chercheurs.
i10-index
Thématiques principales
Affiliations FR : Inserm · Sorbonne Université · Assistance Publique – Hôpitaux de Paris
Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.
Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.
Identification of the specific molecular and functional signatures of pre-beta-HDL: relevance to cardiovascular disease
2023ArticleBasic Research in Cardiology
Microbially Produced Imidazole Propionate Is Associated With Heart Failure and Mortality
2023ArticleJACC: Heart Failure
Integrated omics approach for the identification of HDL structure-function relationships in PCSK9-related familial hypercholesterolemia
2023ArticleJournal of clinical lipidology
Psychosocial effects of hypnosis in patients with obesity: a pilot randomized controlled trial
2023ArticleAmerican Journal of Clinical Hypnosis
Genetic testing of familial hypercholesterolemia: Monogenic form and polygenic contribution to cardiovascular risk
2023Congrès85th Congress of the European-Atherosclerosis-Society (EAS)
Elevated LDL-cholesterol levels among lean mass hyper-responders on low-carbohydrate ketogenic diets deserve urgent clinical attention and further research
2022ArticleJournal of clinical lipidology
Hypnosis Reduces Food Impulsivity in Patients with Obesity and High Levels of Disinhibition: HYPNODIET Randomized Controlled Clinical Trial
2022ArticleThe American Journal of Clinical Nutrition
APOE Molecular Spectrum in a French Cohort with Primary Dyslipidemia
2022ArticleInternational Journal of Molecular Sciences
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).
📰 Doctissimo · 15/11/2022
<a href="https://news.google.com/rss/articles/CBMingFBVV95cUxQdXVGUllLNGx5OWw3dkZnYWFqR1FtOENnczFldDVnYktIbkhHNlZvWnBqV0xvbEFQNk5kdzROVHBnT1RRMjRpZVJXQ0lGWEg5aGplXzZEVkxBN1pXRTJKaXctLUtJcnRYSnlzdmNiT2YydFFqY014dEk4d1VuYTAwUDluUVA2V3FhSW1LU2N3VUdLZUZQM3RkYlI4TjVIUQ?oc=5" target="_blank">Le taux de ch
📰 The Conversation · 30/06/2021
<a href="https://news.google.com/rss/articles/CBMib0FVX3lxTFB1Q05XLXBlWVdpTlJwaFVHZVlzcVBlcUJ3a0xUNWhYMDR5X3VDNkR2a1pSYTBiQzlSWDVqOFpkQVhfY0tibU1xRVlGSWNnT2Q1RUl2VjZCVWE3a0haZTBQZThwOVdxcHVaNUEwRFJJWQ?oc=5" target="_blank">Quel gras consommer cet été ?</a> <font color="#6f6f6f">The Conversation</fon
📰 Le Parisien · 28/11/2019
<a href="https://news.google.com/rss/articles/CBMi0gFBVV95cUxOazB4OV9ieHdBeElfdDJsUjlsU3BzajljOWJPT01yZmxWQjZkY3d3R0hlMXE0QjlCNnRaSDFROVV1QXVqSzJRd3VSQ2YwQ3dsNHZRbzl0UWlGdndsUHlOVlhsckgwMnZYTmt2YXNraTM2bVB3WldXYkhwN2VjbTBvbTJFWVNjeHFnWk8wV3FHSVFSVzNyVEhZX2llSWJzM2hna3RXSWF2OXA5N1Z5bk5ZNzNIRl8tWVFoYU
📰 Santé Magazine · 02/08/2019
<a href="https://news.google.com/rss/articles/CBMizwFBVV95cUxNeFBRd2kzM25VMjhKOEM1dUJiSTdIR1ZHOVllaGg1VUY2ZXdWbDU5eVdnUjIwRVlNX1FSbkpZUDNMdFlJQTlLRjdRYjlZbzZzUFpRaDIyQ3J0TnZCc2VSMzBRZy1xZnA5ZFhkenh5eGNCUFZ3T1pCSkRsaklhcjhxM0pjU0Yyc2JVOE1EYk5BLXVNaWJUQmttUm9QYW5CdVk3cDc3NDFJdEllVU9kMGRDc252djVPZDNUVG
📰 Allo Docteurs · 12/10/2012
<a href="https://news.google.com/rss/articles/CBMikgFBVV95cUxPam1zUm50cFUtWW45LW1Fak1jb0VwYlNYZkNzWlR6UjZBejFpN2R3YmZuVGIzSTMybW1hdHNiVzY5bms4SWRDQm5Gdk9kcHNWVE1nVnY4ZDlKSXp2d1YxWTN4ZGk3bmI0RHFKdTl6OFBTd3paWW1GLUFmZEJ3UzNUaTM2LTYzejlWYkRYYXF1eE15dw?oc=5" target="_blank">Deux pommes par jour éloignen
📰 Allo Docteurs · 29/05/2011
<a href="https://news.google.com/rss/articles/CBMie0FVX3lxTE8ySk5fMXVvclV5eUwzNk9hWHVGMUVmZHZMczJra25kMWlKSG16QVoxMUNHNHc5ZGpPc1VyazJqN2FkY2RkbUxad3hwdm42RXM0Y0lRQ1NRU1RLRTcwQmptRnl3SzNkX1FtUVpnS1ZjRGxFdFFtV1Jua2xZOA?oc=5" target="_blank">Cholestérol : les analyses ?</a> <font color="#6f6f6f">Allo D
📰 Allo Docteurs · 15/05/2011
<a href="https://news.google.com/rss/articles/CBMipgFBVV95cUxPQkV6Sl9xSDVIMTJVY0c4Z3NxRHNNMndfQmFZakRJc3VzaHZVQ2VhMlhsNXZFYnFabFVqTHBma3ZHelRYTUlmWHctbFp1d3FYRm1YUGZkdi1FTU1pMDNURUExZmJxWU5tVk05RThrdXlLS0h5eUEtRFFnQXFWR2lEYWtrX0FzcVVRS2pfY3VoVnY0NFdUeGlGbVpEM2NqRmFDOUZxd2tn?oc=5" target="_blank">Ch@
BMC biology · 2019
AbstractBackgroundManagement of blood cholesterol is a major focus of efforts to prevent cardiovascular diseases. The objective of this study was to investigate how the gut microbiota affects host cholesterol homeostasis at the organism scale.ResultsWe depleted the intestinal microbiota of hypercholesterolemic femaleApoe−/−mice using broad-spectrum antibiotics. Measurement of plasma cholesterol levels as well as cholesterol synthesis and fluxes by complementary approaches showed that the intestinal microbiota strongly regulates plasma cholesterol level, hepatic cholesterol synthesis, and enterohepatic circulation. Moreover, transplant of the microbiota from humans harboring elevated plasma cholesterol levels to recipient mice induced a phenotype of high plasma cholesterol levels in association with a low hepatic cholesterol synthesis and high intestinal absorption pattern. Recipient mice phenotypes correlated with several specific bacterial phylotypes affiliated toBetaproteobacteria,Alistipes,Bacteroides, andBarnesiellataxa.ConclusionsThese results indicate that the intestinal microbiota determines the circulating cholesterol level and may thus represent a novel therapeutic target in the management of dyslipidemia and cardiovascular diseases.
European heart journal · 2019
Abstract Aims The role of statin therapy in primary prevention of cardiovascular disease in persons older than 75 years remains a subject of debate with little evidence to support or exclude the benefit of this treatment. We assessed the effect of statin discontinuation on cardiovascular outcomes in previously adherent 75-year-olds treated for primary prevention. Methods and results A population-based cohort study using French national healthcare databases was performed, studying all subjects who turned 75 in 2012–14, with no history of cardiovascular disease and with a statin medication possession ratio ≥80% in each of the previous 2 years. Statin discontinuation was defined as three consecutive months without exposure. The outcome was hospital admission for cardiovascular event. The hazard ratio comparing statin discontinuation with continuation was estimated using a marginal structural model adjusting for both baseline and time-varying covariates (cardiovascular drug use, comorbidities, and frailty indicators). A total of 120 173 subjects were followed for an average of 2.4 years, of whom 17 204 (14.3%) discontinued statins and 5396 (4.5%) were admitted for a cardiovascular event. The adjusted hazard ratios for statin discontinuation were 1.33 [95% confidence interval (CI) 1.18–1.50] (any cardiovascular event), 1.46 (95% CI 1.21–1.75) (coronary event), 1.26 (95% CI 1.05–1.51) (cerebrovascular event), and 1.02 (95% CI 0.74–1.40) (other vascular event). Conclusion Statin discontinuation was associated with a 33% increased risk of admission for cardiovascular event in 75-year-old primary prevention patients. Future studies, including randomized studies, are needed to confirm these findings and support updating and clarification of guidelines on the use of statins for primary prevention in the elderly.
European journal of preventive cardiology · 2020
BackgroundLow concentrations of high-density lipoprotein cholesterol (HDL-C) represent a well-established cardiovascular risk factor. Paradoxically, extremely high HDL-C levels are equally associated with elevated cardiovascular risk, resulting in the U-shape relationship of HDL-C with cardiovascular disease. Mechanisms underlying this association are presently unknown. We hypothesised that the capacity of high-density lipoprotein (HDL) to acquire free cholesterol upon triglyceride-rich lipoprotein (TGRL) lipolysis by lipoprotein lipase underlies the non-linear relationship between HDL-C and cardiovascular risk.MethodsTo assess our hypothesis, we developed a novel assay to evaluate the capacity of HDL to acquire free cholesterol (as fluorescent TopFluor® cholesterol) from TGRL upon in vitro lipolysis by lipoprotein lipase.ResultsWhen the assay was applied to several populations markedly differing in plasma HDL-C levels, transfer of free cholesterol was significantly decreased in low HDL-C patients with acute myocardial infarction (−45%) and type 2 diabetes (–25%), and in subjects with extremely high HDL-C of >2.59 mmol/L (>100 mg/dL) (−20%) versus healthy normolipidaemic controls. When these data were combined and plotted against HDL-C concentrations, an inverse U-shape relationship was observed. Consistent with these findings, animal studies revealed that the capacity of HDL to acquire cholesterol upon lipolysis was reduced in low HDL-C apolipoprotein A-I knock-out mice and was negatively correlated with aortic accumulation of [3H]-cholesterol after oral gavage, attesting this functional characteristic as a negative metric of postprandial atherosclerosis.ConclusionsFree cholesterol transfer to HDL upon TGRL lipolysis may underlie the U-shape relationship between HDL-C and cardiovascular disease, linking HDL-C to triglyceride metabolism and atherosclerosis.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Molecular metabolism · 2026 · Journal Article
Taradeh M, Hardy LM, Dahik VD, Lhomme M, et al.
JAMA cardiology · 2025 · Journal Article
Le Goff W, Giral P
Journal of clinical lipidology · 2025 · Journal Article
Hansel B, Couvert P, Carrié A, Bittar R, et al.
Journal of lipid research · 2024 · Journal Article
Chapman MJ, Orsoni A, Mellett NA, Nguyen A, et al.
Current research in translational medicine · 2023 · Meta-Analysis
Velásquez IM, Malarstig A, Baldassarre D, Borne Y, et al.
Journal of clinical lipidology · 2023 · Journal Article
Darabi M, Lhomme M, Ponnaiah M, Pučić-Baković M, et al.
Circulation. Genomic and precision medicine · 2023 · Multicenter Study
Maitusong B, Laguzzi F, Strawbridge RJ, Baldassarre D, et al.
Journal of clinical lipidology · 2022 · Editorial
Norwitz NG, Mindrum MR, Giral P, Kontush A, et al.
International journal of molecular sciences · 2022 · Journal Article
Abou Khalil Y, Marmontel O, Ferrières J, Paillard F, et al.
JAMA cardiology · 2022 · Journal Article
Hansel B, Roussel R, Giral P
European heart journal · 2021 · Journal Article
Giral P, Deflorenne E, Kontush A
Biomedicines · 2021 · Journal Article
Coggi D, Frigerio B, Bonomi A, Ruscica M, et al.
Journal of the American Heart Association · 2021 · Journal Article
Mannarino MR, Pirro M, Gigante B, Savonen K, et al.
Biomedicines · 2021 · Journal Article
Colombo GI, Bianconi V, Bonomi A, Simonelli S, et al.
Diabetes/metabolism research and reviews · 2021 · Journal Article
Scicali R, Giral P, D'Erasmo L, Cluzel P, et al.
European journal of nutrition · 2021 · Journal Article
Laguzzi F, Baldassarre D, Veglia F, Strawbridge RJ, et al.
Clinical chemistry · 2020 · Journal Article
Chapman MJ, Giral P, Therond P
Atherosclerosis · 2020 · Journal Article
Ferri N, Ruscica M, Coggi D, Bonomi A, et al.
Journal of lipid research · 2020 · Journal Article
Chapman MJ, Orsoni A, Tan R, Mellett NA, et al.
Nutrition, metabolism, and cardiovascular diseases : NMCD · 2020 · Comparative Study
Bonnefont-Rousselot D, Benouda L, Bittar R, Darabi-Amin M, et al.
Practical laboratory medicine · 2020 · Journal Article
Bittar R, Carrié A, Nouadje G, Cherfils C, et al.
Journal of neurology · 2019 · Journal Article
Mandia D, Chaussenot A, Besson G, Lamari F, et al.
International journal of cardiology · 2019 · Journal Article
Veglia F, Baldassarre D, de Faire U, Kurl S, et al.
Hepatology (Baltimore, Md.) · 2019 · Journal Article
Pais R, Redheuil A, Cluzel P, Ratziu V, et al.
JAMA cardiology · 2026 · Journal Article
Rossi FB, Gallo A, Giral P
Biomedicines · 2025 · Journal Article
Veglia F, Malagoni AM, Amato M, Strawbridge RJ, et al.
Biomedicines · 2024 · Journal Article
Frigerio B, Coggi D, Bonomi A, Amato M, et al.
Scientific reports · 2021 · Journal Article
Laguzzi F, Maitusong B, Strawbridge RJ, Baldassarre D, et al.
Scientific reports · 2021 · Journal Article
Strawbridge RJ, Johnston KJA, Bailey MES, Baldassarre D, et al.
Genes · 2020 · Journal Article
Castaldo L, Laguzzi F, Strawbridge RJ, Baldassarre D, et al.
European heart journal · 2019 · Journal Article
Giral P, Neumann A, Weill A, Coste J
Data in brief · 2019 · Journal Article
Veglia F, Baldassarre D, de Faire U, Kurl S, et al.
European journal of preventive cardiology · 2019 · Journal Article
Nutrition, metabolism, and cardiovascular diseases : NMCD · 2019 · Published Erratum
Mattina A, Giammanco A, Giral P, Rosenbaum D, et al.
Nutrition, metabolism, and cardiovascular diseases : NMCD · 2019 · Comparative Study
Mattina A, Giammanco A, Giral P, Rosenbaum D, et al.
The American journal of clinical hypnosis · 2023 · Randomized Controlled Trial
Untas A, Lamore K, Delestre F, Lehéricey G, et al.
The American journal of clinical nutrition · 2022 · Journal Article
Delestre F, Lehéricey G, Estellat C, Diallo MH, et al.
EBioMedicine · 2021 · Journal Article
Gallo A, Giral P, Rosenbaum D, Mattina A, et al.
BMC biology · 2019 · Journal Article
Le Roy T, Lécuyer E, Chassaing B, Rhimi M, et al.
The New England journal of medicine · 2020 · Letter
Giral P
MOESM11 of The intestinal microbiota regulates host cholesterol homeostasis
Additional file 11: Figure S6. Fecal microbiota composition of normocholesterolemic and high cholesterol recipient mice. (A) Bacterial phyla distribution as percentage of total sequences in mice colonized with the microb
MOESM2 of The intestinal microbiota regulates host cholesterol homeostasis
Additional file 2: Figure S1. Antibiotic treatment efficiently depletes intestinal microbiota. Bacterial 16S DNA load in feces before and after 7 days of antibiotics treatment. 16S DNA was determined by quantitative PCR
MOESM5 of The intestinal microbiota regulates host cholesterol homeostasis
Additional file 5: Figure S3. Antibiotics-induced microbiota depletion does not affect intestinal cholesterol synthesis. Jejunal and ileal expression of HmgcoA reductase in conventionally raised (Conv-R) and microbiota d
MOESM4 of The intestinal microbiota regulates host cholesterol homeostasis
Additional file 4: Table S2. Datapoints for Fig. 2.
MOESM9 of The intestinal microbiota regulates host cholesterol homeostasis
Additional file 9: Figure S4. Relative expression in the liver of normocholesterolemic and high cholesterol recipient mice. Relative expression of genes related bile acid synthesis (Cyp8b1) and bile secretion (Abcg5, 8 a
The intestinal microbiota regulates host cholesterol homeostasis
Abstract Background Management of blood cholesterol is a major focus of efforts to prevent cardiovascular diseases. The objective of this study was to investigate how the gut microbiota affects host cholesterol homeostas
Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).
Atherosclerosis · 2023 · Published Erratum
Ma F, Darabi M, Lhomme M, Tubeuf E, et al.
Basic research in cardiology · 2023 · Journal Article
Guillas I, Lhomme M, Pionneau C, Matheron L, et al.
BioFactors (Oxford, England) · 2022 · Journal Article
Mannarino MR, Bianconi V, Gigante B, Strawbridge RJ, et al.
European heart journal · 2022 · Editorial
Giral P
Atherosclerosis · 2021 · Journal Article
Ma F, Darabi M, Lhomme M, Tubeuf E, et al.
American journal of cardiovascular disease · 2020 · Journal Article
Kirichenko TV, Chernova EV, Chegodaev YS, Kontush A, et al.
European journal of preventive cardiology · 2020 · Journal Article
Feng M, Darabi M, Tubeuf E, Canicio A, et al.
Pharmacoepidemiology and drug safety · 2019 · Journal Article
Coste J, Karras A, Rudnichi A, Dray-Spira R, et al.
Genes and immunity · 2020 · Journal Article
Bonomi A, Veglia F, Baldassarre D, Strawbridge RJ, et al.
Scientific reports · 2019 · Journal Article
Morris J, Bailey MES, Baldassarre D, Cullen B, et al.
Coste J, Billionnet C, Rudnichi A, Pouchot J, et al.