📇 Rhumatologue · VANNES · (56) · Salarié

MME CECILE GAUDIN-HERY

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29 articles scientifiques publiés — un praticien à la pointe de la recherche
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Rhumatologue

📍 VANNES (56)SalariéRPPS 10002530474

✨ Génération du profil synthétique IA en cours…

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RESIDENCES MAREVA LE PARC DU CARMEL
LE PARC DU CARMEL 26 R VINCENT ROUILLE, 56000 VANNES
☎ 0297464354Activité de soin et de pharmacie
RESIDENCES MAREVA LES OREADES
26 R VINCENT ROUILLE, 56000 VANNES
☎ 0297464354Activité de soin et de pharmacie

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Nivolumab in routine practice for older patients with advanced or metastatic non-small cell lung cancer

Journal of geriatric oncology · 2018

📚 20 citations

Peripheral blood haploidentical hematopoietic cell transplantation for patients aged 70 years and over with acute myeloid leukemia or high-risk myelodysplastic syndrome

Bone marrow transplantation · 2024

📚 16 citations🎯 RCR 3.22Top 15% NIH

UBE2E1 Is Preferentially Expressed in the Cytoplasm of Slow-Twitch Fibers and Protects Skeletal Muscles from Exacerbated Atrophy upon Dexamethasone Treatment

Cells · 2018

📚 11 citations🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

Skeletal muscle mass is reduced during many diseases or physiological situations (disuse, aging), which results in decreased strength and increased mortality. Muscle mass is mainly controlled by the ubiquitin-proteasome system (UPS), involving hundreds of ubiquitinating enzymes (E2s and E3s) that target their dedicated substrates for subsequent degradation. We recently demonstrated that MuRF1, an E3 ubiquitin ligase known to bind to sarcomeric proteins (telethonin, α-actin, myosins) during catabolic situations, interacts with 5 different E2 enzymes and that these E2-MuRF1 couples are able to target telethonin, a small sarcomeric protein, for degradation. Amongst the E2s interacting with MuRF1, E2E1 was peculiar as the presence of the substrate was necessary for optimal MuRF1-E2E1 interaction. In this work, we focused on the putative role of E2E1 during skeletal muscle atrophy. We found that E2E1 expression was restricted to type I and type IIA muscle fibers and was not detectable in type IIB fibers. This strongly suggests that E2E1 targets are fiber-specific and may be strongly linked to the contractile and metabolic properties of the skeletal muscle. However, E2E1 knockdown was not sufficient for preserving the protein content in C2C12 myotubes subjected to a catabolic state (dexamethasone treatment), suggesting that E2E1 is not involved in the development of muscle atrophy. By contrast, E2E1 knockdown aggravated the atrophying process in both catabolic C2C12 myotubes and the Tibialis anterior muscle of mice, suggesting that E2E1 has a protective effect on muscle mass.

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MME CECILE GAUDIN-HERY

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Publications scientifiques (29) — classées par pathologie

Gériatrie7

Transversal7

Case report / série5

Revue générale4

Lupus3

Pédiatrie3

Essai clinique2

Vraie vie / RWE2

Corticothérapie1

SAPL1

Vascularites des gros vaisseaux1

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