📇 Rhumatologue ·
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Praticien-chercheur
13 articles scientifiques publiés — formation continue solide
✨ Génération du profil synthétique IA en cours…
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Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Lupus · 2008
Mycophenolate mofetil (MMF) with prednisolone has been associated with high remission rates when used as induction treatment for lupus nephritis. This prospective, multicentre, cohort study investigates the efficacy and safety of this regimen over 24 weeks in 213 Chinese patients with active lupus nephritis (Classes III, IV, V or combination). Baseline activity index (AI) was 6.91 ± 3.33 and chronicity index (CI) was 1.9 ± 1.2. The remission rate was 82.6% at 24 weeks (complete remission, 34.3%; partial remission, 48.4%). There were significant ( P < 0.01) improvements in kidney function shown by reductions in proteinuria, serum albumin, serum creatinine and creatinine clearance, as well as in systemic lupus erythematosus disease activity index (SLEDAI) scores. Independent risk factors influencing remission were pathological classification (including Class V and III or Class V and IV nephritis) and elevated serum creatinine at baseline (OR 2.967, 95% CI: 1.479–6.332, P = 0.001 and OR 1.007, 95% CI: 1.002–1.011, P = 0.001, respectively). Patients with concomitant membranous features on biopsy had a lower remission rate than those with Class III and IV nephritis (66.7% vs 87.3%, P = 0.002). Renal biopsy was repeated in 25 patients following treatment. There was a transition to less severe pathological morphologies in majority of subjects. Infections were monitored throughout treatment: eight patients (3.8%) experienced bacterial infections, whereas herpes zoster occurred in seven patients. Nine patients (4.2%) suffered from gastrointestinal upset, which resolved without discontinuation of MMF. One patient became leucopenic, whereas another died from active disease unrelated to kidney symptoms. MMF combined with prednisolone is an effective and well-tolerated induction treatment for patients with active lupus nephritis and for controlling SLE systemic activity.
Canadian journal of gastroenterology & hepatology · 2022
Background. As the third most common type of cancer in the United States, colorectal cancer (CRC) was previously thought to be rare in young populations. Despite a decrease in the overall incidence of CRC, the rate of new cases under 50 years old has been continuously increasing. Aim. The purpose of our study was to analyze risk factors of young-onset CRC. Methods. Commercially available software platform, Explorys, was used to extract data from a collective healthcare database electronically. Results. In this database, 13,800 young adults (age 20–50) were diagnosed with primary colorectal malignancy. Compared to subjects with a previous family history of CRC who had an odds ratio of 17.78, those diagnosed with primary malignant neoplasm of breast and inflammatory bowel disease (ulcerative colitis and Crohn’s) had odds ratios of 16.94, 4.4, and 3.7 for young-onset CRC, respectively. Patients with a history of alcohol abuse, smoking, obesity, diabetes mellitus, and hyperlipidemia had higher chances of developing young-onset CRC. In addition, the odds of CRC were lower in Hispanic ethnicity in comparison to Caucasians (OR: 0.54), with no statically significant differences between Caucasian, African American, and Asian populations. Conclusion. Currently, this is an expansive study investigating the risk factors for early-onset CRC. The analysis showed factors such as family and individual history of IBD to have high association with early onset. Notably, an individual history of breast malignancy was strongly associated with early-onset CRC.
PloS one · 2020
ObjectivesThe study examined the prevalence, sociodemographic, and clinical correlates of chronic pain among primary care patients in the state of Kerala, India. It also examined the patterns and relationships of chronic physical and mental health conditions with chronic pain.MethodsThis study is a cross-sectional survey conducted among 7165 adult patients selected randomly by a multi-stage stratified design from 71 primary health centers. The questionnaires administered included Chronic pain screening questionnaire, self-reported Chronic physical health condition checklist, Patient Health Questionnaire-SADS, The Alcohol Use Disorders Identification Test, Fagerström Test for Nicotine Dependence, WHO Disability Assessment Schedule and WHOQOL- BREF for Quality/Satisfaction with Life. The prevalence and comorbid patterns of chronic pain were determined. Logistic regression analysis and generalized linear mixed-effects model was employed to examine the relationship of chronic pain to socio-demographic variables and examined physical and mental health conditions.ResultsA total of 1831 (27%) patients reported chronic pain. Among those with chronic pain, 28.3% reported no co-occurring chronic mental or physical illness, 35.3% reported one, and 36.3% reported multi-morbidity. In the multivariate analysis, patients with chronic pain when compared to those without had higher odds of being older, female, having lower education, not living with their family, greater disability, and poor satisfaction with life. Chronic pain was independently associated with both medical (hypertension, diabetes mellitus, tuberculosis, arthritis, and other medical illnesses) and mental health conditions (depressive disorders, anxiety disorders, and tobacco dependence). It showed a varying strength of association and additive effect with increasing number of co-occurring physical and mental illnesses.ConclusionsChronic pain is a common condition among primary care attendees associated with significant burden of medical and mental health comorbidity. The findings highlight the need to incorporate treatment models that will ensure appropriate management to improve outcomes within the resource constraints.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
The Egyptian journal of immunology · 2023 · Journal Article
Romualde DS, Liliane SK, Koffi N, Honoré AA, et al.
The Journal of the Association of Physicians of India · 2022 · Journal Article
Nair A, Pruthi P, L S, Marwaha V, et al.
International journal of surgical pathology · 2021 · Case Reports
Anja K, Hélène D, Pascal VE, Liliane M, et al.
PloS one · 2020 · Journal Article
Desai G, T S J, G SK, L M, et al.
Medical mycology case reports · 2015 · Journal Article
Sophie B, Coralie Z, Mai Ba H, Annie L, et al.
Experimental and therapeutic medicine · 2013 · Journal Article
Wong JY, Chen YS, Chakravarthi S, Judson JP, et al.
Cureus · 2025 · Case Reports
Ghosh S, Vittobarao PG, S S, L A, et al.
Current diabetes reviews · 2020 · Case Reports
Amelie M, Magalie D, Liliane T, Merzaka B, et al.
Reviews in endocrine & metabolic disorders · 2020 · Journal Article
Laurent I, Astère M, Paul B, Liliane N, et al.
Current diabetes reviews · 2020 · Case Reports
Amelie M, Magalie D, Liliane T, Merzaka B, et al.
Lupus · 2008 · Clinical Trial
F L, Y T, X P, L W, et al.
Canadian journal of gastroenterology & hepatology · 2022 · Journal Article
Danial D, Youssef ED, Maryam BM, Mohammad A, et al.
Frontiers in public health · 2026 · Journal Article
Mandeng E, Ritha MB, Tchetchia A, Liliane MJ, et al.
Zhongguo gu shang = China journal of orthopaedics and traumatology · 2023 · Meta-Analysis
Zhou GB, Lyu Y, L J, Lin ZH, et al.