📇 Rhumatologue · Salarié

M PHILIPPE GACHIGNAT

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Auteur de référence en rhumatologie
32 articles scientifiques publiés — un praticien à la pointe de la recherche

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Top publications · les plus citées

The Impact of Metabolic Complications in Pregnancy on Later Life Maternal Cardiometabolic Health: Findings From the ROLO Longitudinal Cohort Study

BJOG : an international journal of obstetrics and gynaecology · 2026

📚 2 citations🔓 Open Access📄 PDF gratuit ↗

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ABSTRACT Objective To explore associations between pregnancy metabolic complications and maternal cardiometabolic health 10 years postpartum. Design Prospective Longitudinal Cohort Study following a randomised controlled trial. Setting Single‐centre. Population Pregnancy metabolic complication (pregnancy‐induced hypertension, impaired glucose tolerance, or gestational diabetes) versus an uncomplicated pregnancy in secundigravid women who previously delivered a macrosomic infant. Methods Health and lifestyle data were obtained from 422 women during pregnancy and again 10 years postpartum. Anthropometry, dual‐energy X‐ray absorptiometry scans, and non‐fasting blood samples were recorded 10 years postpartum. Unadjusted and adjusted linear regression explored associations between pregnancy metabolic complications and cardiometabolic markers with adjustment for potential confounders (study group allocation, age at follow‐up, maternal ethnicity, early pregnancy body mass index (BMI), use of cardiometabolic medications, maternal smoking at 10 years postpartum, and socio‐economic status). Main Outcome Measures Cardiometabolic risk profile 10 years postpartum. Results Of 422 women, 27.7% ( n = 117) experienced a metabolic complication in pregnancy. Pregnancy metabolic complications were associated with greater postpartum weight retention ( ß = 1.72, 95% CI 0.08, 3.36), higher BMI ( ß = 0.70, 95% CI 0.09, 1.31), greater visceral adipose tissue mass ( ß = 0.12, 95% CI 0.01, 0.23), greater total cholesterol ( ß = 0.36, 95% CI 0.15, 0.58), greater LDL‐cholesterol ( ß = 0.29, 95% CI 0.09, 0.50), greater triglycerides ( ß = 0.06, 95% CI 0.03, 0.32), and greater glucose ( ß = 0.22, 95% CI 0.03, 0.40) at 10 years postpartum. Conclusions Pregnancy metabolic complications were associated with an altered cardiometabolic risk profile 10 years postpartum.

Mass Medical Evacuations to Decrease the Intensive Care Burden: Results From the Mass Transfer of COVID-19 Patients (TRANSCOV) Cohort Study

Chest · 2026

📚 1 citations

First 1000 Days Strategies to Prevent Childhood Obesity: A Narrative Review and Recommendations From the EndObesity Consortium

Pediatric obesity · 2026

📚 1 citations🔓 Open Access📄 PDF gratuit ↗

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ABSTRACT Childhood obesity remains a major global public health challenge, leading to significant short‐ and long‐term adverse health outcomes and imposing substantial societal costs. Recognising the critical importance of early intervention, the Horizon2020 EU‐funded JPI Consortium EndObesity has prioritised the first 1000 days of life, from preconception to 2 years of age, as a key window for obesity prevention strategies. This narrative review synthesises findings from the EndObesity Consortium, summarising evidence from large multi‐cohort studies on the influence of family‐based health behaviours in the first 1000 days on offspring obesity risk, the potential of childhood obesity prediction models in the first 1000 days, and strategies to enhance prenatal and postnatal interventions to prevent childhood obesity development. Finally, we present recommendations for research, practice, and policy to address the complex, multifaceted challenges of childhood obesity prevention in the first 1000 days.

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M PHILIPPE GACHIGNAT

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Top publications · les plus citées

Publications scientifiques (32) — classées par pathologie

Transversal13

Revue générale9

Épidémiologie & registres4

Biomarqueurs / Auto-Ac2

Pédiatrie2

Case report / série1

Économie santé1

Essai clinique1

Génétique1

Microbiote1

Qualité de vie / PROMs1

Santé mentale / fatigue1

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