📇 Rhumatologue · LA CHAPELLE ST MESMIN · (45) · Salarié

MME Sylvie FUCHS

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Auteur de référence en rhumatologie
23 articles scientifiques publiés — un praticien à la pointe de la recherche
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81.7 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 LA CHAPELLE ST MESMIN (45)SalariéRPPS 10001411056

✨ Génération du profil synthétique IA en cours…

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CRFA LE COTEAU
3 B R DES HAUTS, 45380 LA CHAPELLE ST MESMIN
☎ 0238455555Activité de soin et de pharmacie

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Top publications · les plus citées

Quality of life 20 years after arthrodesis of the ankle. A study of adjacent joints

The Journal of bone and joint surgery. British volume · 2003

📚 248 citations🎯 RCR 12.73Top 2% NIH🔓 Open Access📄 PDF gratuit ↗

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Tibiotalar fusion is considered to be the standard treatment for end-stage post-traumatic arthritis of the ankle. We report a retrospective, objective long-term study of the quality of life of 17 patients with 18 arthrodeses of the ankle, over a period of more than 20 years. We looked particularly for correlation between clinical and radiological signs of osteoarthritis in adjoining joints. At serial physical examinations, clinical grades were awarded according to the Olerud Molander Ankle (OMA) score. Any degree of degenerative change in the adjoining joints was recorded on standing radiographs. Patients filled out a SF-36 Health Survey form. Subjectively, 50% of patients were not handicapped in the performance of daily activities and 44% were in the same job as at the time of injury. At follow-up the mean OMA score was 59.4 points, the visual analogue scale was 1.99 and the radiological score was 2.7. The SF-36 for physical function, emotional disturbance and bodily pain revealed significant deficits. There was a significant correlation between the OMA and the radiological score (p = 0.05), and between the clinical and the SF-36 score (p = 0.01), but no significant correlation between the radiological score and the SF-36 score. Arthrodesis of the ankle leads to deficits in the functional outcome, to limitations in the activities of daily living and to radiological changes in the adjoining joints. The clinical outcome score correlates closely with the SF-36 score.

Dissociation between bone resorption and bone formation in osteopenic transgenic mice

Proceedings of the National Academy of Sciences of the United States of America · 1998

📚 161 citations🎯 RCR 3.32Top 14% NIH🔓 Open Access

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Bone mass is maintained constant in vertebrates through bone remodeling (BR). BR is characterized by osteoclastic resorption of preexisting bone followed by de novo bone formation by osteoblasts. This sequence of events and the fact that bone mass remains constant in physiological situation lead to the assumption that resorption and formation are regulated by each other during BR. Recent evidence shows that cells of the osteoblastic lineage are involved in osteoclast differentiation. However, the existence of a functional link between the two activities, formation and resorption, has never been shown in vivo . To define the role of bone formation in the control of bone resorption, we generated an inducible osteoblast ablation mouse model. These mice developed a reversible osteopenia. Functional analyses showed that in the absence of bone formation, bone resorption continued to occur normally, leading to an osteoporosis of controllable severity, whose appearance could be prevented by an antiresorptive agent. This study establishes that bone formation and/or bone mass do not control the extent of bone resorption in vivo .

Intra-articular hyaluronic acid compared with corticoid injections for the treatment of rhizarthrosis

Osteoarthritis and cartilage · 2006

📚 87 citations🎯 RCR 3.74Top 12% NIH🩺 Clinique

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MME Sylvie FUCHS

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Lieu de consultation

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Top publications · les plus citées

Publications scientifiques (23) — classées par pathologie

Transversal12

Qualité de vie / PROMs5

Épidémiologie & registres3

Activité physique / Rééducation1

Lupus1

Pédiatrie1

Revue générale1

Vraie vie / RWE1

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