📇 Rhumatologue ·

MME PATRICIA FRANCO

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Auteur de référence en rhumatologie
47 articles scientifiques publiés — un praticien à la pointe de la recherche
Encadrant universitaire
Forme la prochaine génération de rhumatologues (6 thèses dirigées)
Référence presse grand public
Cité 2 fois dans les médias — pédagogie reconnue

Rhumatologue

RPPS 10001129815

Enseignement

📊 Reconnaissance scientifique : 49/100📝 523 articles publiés🇫🇷 Publications académiques françaises (8)🎓 6 thèses dirigées

✨ Génération du profil synthétique IA en cours…

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🎓 6 thèses dirigées

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Safety and efficacy of pitolisant in children aged 6 years or older with narcolepsy with or without cataplexy: a double-blind, randomised, placebo-controlled trial

The Lancet. Neurology · 2023

📚 26 citations🎯 RCR 5.09Top 8% NIH🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

Comorbid parasomnias in narcolepsy and idiopathic hypersomnia: more REM than NREM parasomnias

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022

📚 21 citations🎯 RCR 2.89Top 17% NIH🔓 Open Access📄 PDF gratuit ↗

Characterization of rapid weight gain phenotype in children with narcolepsy

CNS neuroscience & therapeutics · 2022

📚 11 citations🎯 RCR 1.34🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

AbstractObjectivesTo characterize the rapid weight gain (RWG) phenotype associated with the onset of childhood narcolepsy and to determine whether it could constitute a marker of severity of the disease.MethodsRWG was defined using the BMI z‐score slope reported to one year (>0.67 SD) from symptom onset to disease diagnosis. We compared the clinical, metabolic, and sleep characteristics between patients with or without RWG at diagnosis. Pharmacological management, anthropometric, and clinical progression were also evaluated during the follow‐up.ResultsA total of 84 de novo narcoleptic pediatric patients were included; their median age at diagnosis was 12.0 years; 59.5% boys, 90.5% cataplexy, and 98.7% HLA‐DQB1*06:02, 57% had RWG profile. RWG patients were younger at diagnosis than non‐RWG patients, despite a shorter diagnostic delay. They had a higher BMI z‐score and a higher prevalence of obesity at diagnosis, but not at symptom onset, and higher adapted Epworth Sleepiness Scale and Insomnia Severity Index scores than non‐RWG patients. No differences on nocturnal polysomnography and multiple sleep latency tests were found between groups at disease diagnosis. After a median follow‐up of 5 years, RWG patients still had a higher BMI z‐score and a higher prevalence of obesity despite benefiting from the same therapeutic management and displaying improvement in sleepiness and school difficulties.ConclusionsNarcoleptic RWG patients were younger, sleepier, and the prevalence of obesity was higher at diagnosis despite a shorter diagnostic delay than that of non‐RWG patients. These patients had also a higher risk of developing a long‐term obesity, despite a positive progression of their narcoleptic symptoms. RGW could then represent a maker of a more severe phenotype of childhood narcolepsy, which should inspire a prompt and more offensive management to prevent obesity and its complications.

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MME PATRICIA FRANCO

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Articles de presse (2)

Top publications · les plus citées

Publications scientifiques (47) — classées par pathologie

Santé mentale / fatigue34

Pédiatrie29

Transversal3

Économie santé2

Gériatrie2

Revue générale2

Vraie vie / RWE2

Activité physique / Rééducation1

Case report / série1

Essai clinique1

Génétique1

Pharmacovigilance1

Revue / méta-analyse1

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