📇 Rhumatologue · LA TRONCHE · (38) · Hospitalier

MME VALERIE FRAIX

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3 raisons identifiées

Auteur de référence en rhumatologie
47 articles scientifiques publiés — un praticien à la pointe de la recherche
Expérience confirmée
18 ans d'exercice en rhumatologie — recul clinique solide
Délais de RDV courts dans la région
120.1 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 LA TRONCHE (38)HospitalierRPPS 10003096913

Expérience confirmée

18ans d'exercice (thèse 2008)

📊 Reconnaissance scientifique : 50/100📝 202 articles publiés🇫🇷 Publications académiques françaises (8)

✨ Génération du profil synthétique IA en cours…

Thèses universitaires

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Long-term Outcomes (15 Years) After Subthalamic Nucleus Deep Brain Stimulation in Patients With Parkinson Disease

Neurology · 2021

📚 101 citations🎯 RCR 9.53Top 3% NIH🔓 Open Access📄 PDF gratuit ↗

Quality of life predicts outcome of deep brain stimulation in early Parkinson disease

Neurology · 2019

📚 75 citations🎯 RCR 4.88Top 8% NIH🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

Predictors of Long-Term Outcome of Subthalamic Stimulation in Parkinson Disease

Annals of neurology · 2021

📚 72 citations🎯 RCR 6.62Top 5% NIH🔓 Open Access

Lire l'abstract Crossref ↓

ObjectiveThis study was undertaken to identify preoperative predictive factors of long‐term motor outcome in a large cohort of consecutive Parkinson disease (PD) patients with bilateral subthalamic nucleus deep brain stimulation (STN‐DBS).MethodsAll consecutive PD patients who underwent bilateral STN‐DBS at the Grenoble University Hospital (France) from 1993 to 2015 were evaluated before surgery, at 1 year (short‐term), and in the long term after surgery. All available demographic variables, neuroimaging data, and clinical characteristics were collected. Preoperative predictors of long‐term motor outcome were investigated by performing survival and univariate/multivariate Cox regression analyses. Loss of motor benefit from stimulation in the long term was defined as a reduction of less than 25% in the Movement Disorder Society–sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS) part III scores compared to the baseline off‐medication scores. As a secondary objective, potential predictors of short‐term motor outcome after STN‐DBS were assessed by performing univariate and multivariate linear regression analyses.ResultsIn the long‐term analyses (mean follow‐up = 8.4 ± 6.26 years, median = 10 years, range = 1–17 years), 138 patients were included. Preoperative higher frontal score and off‐medication MDS‐UPDRS part III scores predicted a better long‐term motor response to stimulation, whereas the presence of vascular changes on neuroimaging predicted a worse motor outcome. In 357 patients with available 1‐year follow‐up, preoperative levodopa response, tremor dominant phenotype, baseline frontal score, and off‐medication MDS‐UPDRS part III scores predicted the short‐term motor outcome.InterpretationFrontal lobe dysfunction, disease severity in the off‐medication condition, and the presence of vascular changes on neuroimaging represent the main preoperative clinical predictors of long‐term motor STN‐DBS effects. ANN NEUROL 2021;89:587–597

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MME VALERIE FRAIX

Pourquoi vous devez consulter ce praticien

Thèses universitaires

Activité de recherche & publications

Publications académiques en France

Lieu de consultation

Tarifs & secteur de conventionnement

Prendre rendez-vous & contact

Top publications · les plus citées

Publications scientifiques (47) — classées par pathologie

Transversal36

Qualité de vie / PROMs3

Essai clinique2

Santé mentale / fatigue2

Économie santé1

Épidémiologie & registres1

Génétique1

Pédiatrie1

Revue / méta-analyse1

Revue générale1

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