📇 Rhumatologue ·
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Praticien-chercheur
10 articles scientifiques publiés — formation continue solide
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Arthritis and rheumatism · 1980
AbstractDetermination of the specificities of antinuclear antibodies in the sera of 20 dogs presenting with symptoms of a lupus‐like syndrome permitted their separation into 2 groups. The first group of 14 dogs all had antibody activity to DNA‐histone antigen(s), and 4 of them also had antibodies to native DNA (nDNA). The Farr test with standard buffer was found to be unsatisfactory for the measurement of anti‐nDNA antibodies in dog sera due to a high incidence of false positive reactions; these could be eliminated by the inclusion of sodium dodecyl sulfate in the buffer system. The second group of 6 dogs was characterized by the presence of antibodies to extractable nuclear antigen. In every serum tested diseased dogs had a diminished level of circulating thymic factor as compared to controls of the same age, suggesting that a diminution of suppressor T cells may be an etiologic factor.
Lupus · 1992
We studied 75 cases of canine systemic lupus erythematosus (SLE) presenting with at least four criteria of the American Rheumatism Association (ARA), including antinuclear antibodies (ANAb). This disease mainly affects male German shepherds of an average age of 5 years. The most common clinical signs are polyarthritis (91 % of cases), and renal (65 %) and cutaneo mucous disorders (60%). Hemolytic anemia is rare (13%). ANAb are present, often at high levels (> 256 up to 106 by indirect immunofluorescence on mouse blood smears). The titers are correlated with the severity and the stage of the disease. As double-stranded DNA Ab are rare and as antihistone Ab are frequent, the former could be replaced by the latter in the ARA criteria applied to the SLE dog. Another category of ANAb, named anti-type 1, also seems useful in diagnosing canine SLE. As for therapy, long-term remissions (up to 9 years without treatment) were obtained in 55.6% of 27 SLE dogs treated by levamisole. At first, levamisole was associated with induction corticotherapy, then administered alone and finally discon tinued. Side effects were uncommon and transient.
Veterinary immunology and immunopathology · 1984
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Autoimmunity · 1995 · Journal Article
Chabanne L, Fournel C, Caux C, Bernaud J, et al.
Lupus · 1992 · Journal Article
Monier JC, Ritter J, Caux C, Chabanne L, et al.
Lupus · 1992 · Comparative Study
Fournel C, Chabanne L, Caux C, Faure JR, et al.
Clinical immunology and immunopathology · 1990 · Journal Article
Teichner M, Krumbacher K, Doxiadis I, Doxiadis G, et al.
Clinical and experimental immunology · 1988 · Journal Article
Brinet A, Fournel C, Faure JR, Venet C, et al.
American journal of veterinary research · 1988 · Journal Article
Monier JC, Fournel C, Lapras M, Dardenne M, et al.
Journal of comparative pathology · 1988 · Journal Article
Hubert B, Teichner M, Fournel C, Monier JC
Veterinary immunology and immunopathology · 1984 · Comparative Study
Costa O, Fournel C, Lotchouang E, Monier JC, et al.
American journal of veterinary research · 1983 · Journal Article
Rigal D, Bendali-Ahcène S, Monier JC, Mohana K, et al.
Arthritis and rheumatism · 1980 · Journal Article
Monier JC, Dardenne M, Rigal D, Costa O, et al.