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4 raisons identifiées
Auteur de référence en rhumatologie
25 articles scientifiques publiés — un praticien à la pointe de la recherche
Encadrant universitaire
Forme la prochaine génération de rhumatologues (1 thèse dirigée)
Référence presse grand public
Cité 1 fois dans les médias — pédagogie reconnue
Expérience confirmée
25 ans d'exercice en rhumatologie — recul clinique solide
25ans d'exercice (thèse 2001)
✨ Génération du profil synthétique IA en cours…
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Value of autologous stem cell transplantation for nGn-Hodgkin's lymphomas
Direction : Patrick Hervé
Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.
Source theses.fr — signal de direction d'équipe / statut PU-PH (à confirmer via le site universitaire).
Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.
Long-term outcome of imatinib 400 mg compared to imatinib 600 mg or imatinib 400 mg daily in combination with cytarabine or pegylated interferon alpha 2a for chronic myeloid leukaemia: results from the French SPIRIT phase III randomised trial
2021ArticleLeukemia
Tandem autologous stem cell transplantation improves outcome in newly diagnosed multiple myeloma with extramedullary disease and high-risk cytogenetics: a study from the chronic malignancies working party of ebmt
2019ArticleBiology of Blood and Marrow Transplantation
When hemolysis masks polycythemia vera
2019ArticleClinical Case Reports
A case of B-cell precursor acute lymphoblastic leukemia with IL3-IGH rearrangement revealed by thromboembolism and marked eosinophilia
2018ArticleLeukemia & lymphoma
Double umbilical cord blood transplantation for hematological malignancies: a long- term analysis from the SFGM-TC registry.
2013ArticleExperimental Hematology
Use of Mesenchymal Stem Cells (MSC) in Chronic Inflammatory Fistulizing and Fibrotic Diseases: a Comprehensive Review
2013ArticleClinical Reviews in Allergy & Immunology
Clinical-grade production of human mesenchymal stromal cells: occurrence of aneuploidy without transformation.
2010ArticleBlood
Selected Stro-1-enriched bone marrow stromal cells display a major suppressive effect on lymphocyte proliferation.
2009ArticleInternational Journal of Laboratory Hematology
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).
📰 Le Parisien · 20/06/2016
<a href="https://news.google.com/rss/articles/CBMivgFBVV95cUxOMExzNjJfSnZ4SVo2RTVxNTNnNjV2WEhmMEctWG9lMHlJV2ladW1rYVJQY2pzeGJrSkNJTGdFT0FEQ2FoalJ6WXNNakpIeTZaczBTblU3SllFdkNCay0wc3ZvWXBPUER2RWRBLVd0RVRMalZvbzFldFUxdV8yVy1KR2RhcU8wUU1RZDktNm9SbkpnRXYySGcwQUswT200aUd4dE51ajBDd29iNFJJQloyUEE2WTJTbnJPem
Blood · 2010
Abstract Clinical-grade human mesenchymal stromal cells (MSCs) have been expanded in vitro for tissue engineering or immunoregulatory purposes without standardized culture conditions or release criteria. Although human MSCs show poor susceptibility for oncogenic transformation, 2 recent studies described their capacity to accumulate chromosomal instability and to give rise to carcinoma in immunocompromised mice after long-term culture. We thus investigated the immunologic and genetic features of MSCs expanded with fetal calf serum and fibroblast growth factor or with platelet lysate in 4 cell-therapy facilities during 2 multicenter clinical trials. Cultured MSCs showed a moderate expression of human leukocyte antigen-DR without alteration of their low immunogenicity or their immunomodulatory capacity. Moreover, some transient and donor-dependent recurring aneuploidy was detected in vitro, independently of the culture process. However, MSCs with or without chromosomal alterations showed progressive growth arrest and entered senescence without evidence of transformation either in vitro or in vivo.
The journal of gene medicine · 2003
AbstractBackgroundRecent studies have suggested that ex vivo expansion of autologous hematopoietic cells could be a therapy of choice for the treatment of bone marrow failure. We investigated the potential of a combined infusion of autologous ex vivo expanded hematopoietic cells with mesenchymal (MSCs) for the treatment of multi‐organ failure syndrome following irradiation in a non‐human primate model.MethodsHematopoietic cells and MSCs were expanded from bone marrow aspirates. MSCs were transduced with the gene encoding for the green fluorescent protein (e‐GFP), in order to track them following infusion. Twelve animals were studied. Nine animals received total‐body irradiation at 8 Gy from a neutron/gamma source thus resulting in heterogeneous exposure; three animals were sham‐irradiated. The animals were treated with expanded hematopoietic stem cells and MSCs, expanded hematopoietic stem cells alone, or MSCs alone. Unmanipulated bone marrow cell transplants were used as controls.ResultsDepending on the neutron/gamma ratio, an acute radiation sickness of varying severity but of similar nature resulted. GFP‐labeled cells were found in the injured muscle, skin, bone marrow and gut of the treated animals via PCR up to 82 days post‐infusion.ConclusionsThis is the first evidence of expanded MSCs homing in numerous tissues following a severe multi‐organ injury in primates. Localization of the transduced MSCs correlated to the severity and geometry of irradiation. A repair process was observed in various tissues. The plasticity potential of the MSCs and their contribution to the repair process in vivo remains to be studied. Copyright © 2003 John Wiley & Sons, Ltd.
Transplantation · 2007
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
The American Journal of dermatopathology · 2021 · Case Reports
Mongereau M, Hillion B, Fouillard L, Boivin JF, et al.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2019 · Clinical Trial
Gagelmann N, Eikema DJ, Koster L, Caillot D, et al.
Clinical case reports · 2019 · Case Reports
Derrieux C, Jeandel R, Martin A, Dosquet C, et al.
Leukemia & lymphoma · 2018 · Case Reports
Derrieux C, Freynet N, Frayfer J, Delabesse E, et al.
Leukemia & lymphoma · 2014 · Case Reports
Cacoub L, Touati S, Yver M, Frayfer J, et al.
Current pharmaceutical biotechnology · 2013 · Journal Article
Fouillard L, Francois S, Bouchet S, Bensidhoum M, et al.
Blood · 2010 · Journal Article
Tarte K, Gaillard J, Lataillade JJ, Fouillard L, et al.
Haematologica · 2008 · Journal Article
Fouillard L, Labopin M, Gratwohl A, Gluckman E, et al.
Cellular immunology · 2008 · Journal Article
Nasef A, Mazurier C, Bouchet S, François S, et al.
Transplantation · 2007 · Journal Article
Nasef A, Mathieu N, Chapel A, Frick J, et al.
Gene expression · 2007 · Journal Article
Nasef A, Chapel A, Mazurier C, Bouchet S, et al.
Zhonghua yi xue za zhi · 2005 · Journal Article
Zhang YZ, Fouillard L, Chapel A, Bensidhoum M, et al.
Blood · 2004 · Journal Article
Bensidhoum M, Chapel A, Francois S, Demarquay C, et al.
Haematologica · 2004 · Comparative Study
Fouillard L, Labopin M, Meloni G, Polge E, et al.
The journal of gene medicine · 2003 · Journal Article
Chapel A, Bertho JM, Bensidhoum M, Fouillard L, et al.
Blood · 2002 · Evaluation Study
Fouillard L, Labopin M, Gorin NC, Polge E, et al.
Bone marrow transplantation · 1999 · Clinical Trial
Tyndall A, Fassas A, Passweg J, Ruiz de Elvira C, et al.
Experimental hematology · 2013 · Journal Article
Wallet HL, Sobh M, Morisset S, Robin M, et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2009 · Journal Article
Gorin NC, Labopin M, Blaise D, Reiffers J, et al.
Leukemia · 2021 · Clinical Trial, Phase III
Guilhot F, Rigal-Huguet F, Guilhot J, Guerci-Bresler AP, et al.
Blood · 2014 · Clinical Trial, Phase II
Döhner H, Lübbert M, Fiedler W, Fouillard L, et al.
Lupus · 2004 · Comparative Study
Jayne D, Passweg J, Marmont A, Farge D, et al.
Lupus · 1999 · Case Reports
Fouillard L, Gorin NC, Laporte JP, Leon A, et al.
The Journal of infection · 2022 · Journal Article
Mikulska M, Knelange N, Nicolini LA, Tridello G, et al.
Clinical reviews in allergy & immunology · 2013 · Journal Article
Voswinkel J, Francois S, Simon JM, Benderitter M, et al.