📇 Rhumatologue ·

M LOIC FOUILLARD

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4 raisons identifiées

Auteur de référence en rhumatologie
25 articles scientifiques publiés — un praticien à la pointe de la recherche
Encadrant universitaire
Forme la prochaine génération de rhumatologues (1 thèse dirigée)
Référence presse grand public
Cité 1 fois dans les médias — pédagogie reconnue
Expérience confirmée
25 ans d'exercice en rhumatologie — recul clinique solide

Rhumatologue

RPPS 10000554955

Expérience confirmée

25ans d'exercice (thèse 2001)

🇫🇷 Publications académiques françaises (8)🎓 1 thèse dirigée

✨ Génération du profil synthétique IA en cours…

Thèses universitaires

Intérêt de l'autogreffe de cellules souches hématopoi͏̈etiques pour le traitement des lymphomes malins non-hodgkiniens
2001

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Clinical-grade production of human mesenchymal stromal cells: occurrence of aneuploidy without transformation

Blood · 2010

📚 354 citations🎯 RCR 10.11Top 3% NIH🔓 Open Access📄 PDF gratuit ↗

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Abstract Clinical-grade human mesenchymal stromal cells (MSCs) have been expanded in vitro for tissue engineering or immunoregulatory purposes without standardized culture conditions or release criteria. Although human MSCs show poor susceptibility for oncogenic transformation, 2 recent studies described their capacity to accumulate chromosomal instability and to give rise to carcinoma in immunocompromised mice after long-term culture. We thus investigated the immunologic and genetic features of MSCs expanded with fetal calf serum and fibroblast growth factor or with platelet lysate in 4 cell-therapy facilities during 2 multicenter clinical trials. Cultured MSCs showed a moderate expression of human leukocyte antigen-DR without alteration of their low immunogenicity or their immunomodulatory capacity. Moreover, some transient and donor-dependent recurring aneuploidy was detected in vitro, independently of the culture process. However, MSCs with or without chromosomal alterations showed progressive growth arrest and entered senescence without evidence of transformation either in vitro or in vivo.

Mesenchymal stem cells home to injured tissues when co-infused with hematopoietic cells to treat a radiation-induced multi-organ failure syndrome

The journal of gene medicine · 2003

📚 331 citations🎯 RCR 7.79Top 4% NIH🔓 Open Access

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AbstractBackgroundRecent studies have suggested that ex vivo expansion of autologous hematopoietic cells could be a therapy of choice for the treatment of bone marrow failure. We investigated the potential of a combined infusion of autologous ex vivo expanded hematopoietic cells with mesenchymal (MSCs) for the treatment of multi‐organ failure syndrome following irradiation in a non‐human primate model.MethodsHematopoietic cells and MSCs were expanded from bone marrow aspirates. MSCs were transduced with the gene encoding for the green fluorescent protein (e‐GFP), in order to track them following infusion. Twelve animals were studied. Nine animals received total‐body irradiation at 8 Gy from a neutron/gamma source thus resulting in heterogeneous exposure; three animals were sham‐irradiated. The animals were treated with expanded hematopoietic stem cells and MSCs, expanded hematopoietic stem cells alone, or MSCs alone. Unmanipulated bone marrow cell transplants were used as controls.ResultsDepending on the neutron/gamma ratio, an acute radiation sickness of varying severity but of similar nature resulted. GFP‐labeled cells were found in the injured muscle, skin, bone marrow and gut of the treated animals via PCR up to 82 days post‐infusion.ConclusionsThis is the first evidence of expanded MSCs homing in numerous tissues following a severe multi‐organ injury in primates. Localization of the transduced MSCs correlated to the severity and geometry of irradiation. A repair process was observed in various tissues. The plasticity potential of the MSCs and their contribution to the repair process in vivo remains to be studied. Copyright © 2003 John Wiley & Sons, Ltd.

Immunosuppressive effects of mesenchymal stem cells: involvement of HLA-G

Transplantation · 2007

📚 268 citations🎯 RCR 6.93Top 5% NIH

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M LOIC FOUILLARD

Pourquoi vous devez consulter ce praticien

Thèses universitaires

Direction de thèses

Publications académiques en France

Lieu de consultation

Tarifs & secteur de conventionnement

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Articles de presse (1)

Top publications · les plus citées

Publications scientifiques (25) — classées par pathologie

Transversal17

Épidémiologie & registres2

Essai clinique2

Lupus2

Pharmacovigilance1

Revue générale1

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