📇 Rhumatologue · BAYONNE CEDEX · (64) · Salarié
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2 raisons identifiées
Praticien-chercheur
6 articles scientifiques publiés — formation continue solide
Délais de RDV courts dans la région
166.7 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.
Influence scientifique
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
10
10 articles ont été cités au moins 10fois par d'autres chercheurs — preuve que ses travaux sont repris par la communauté médicale.
h-index
Total citations reçues
394
Nombre de fois où d'autres équipes ont mentionné ses publications dans leurs propres travaux.
Publications totales
39
Articles, revues et chapitres référencés dans les bases académiques internationales.
Articles influents
10
Publications ayant marqué leur domaine — chacune citée au moins 10 fois par d'autres chercheurs.
i10-index
Thématiques principales
Affiliations FR : Centre Hospitalier de la Côte Basque
Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.
Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.
Paraneoplastic Neurologic Syndromes Associated With Merkel Cell Carcinoma
2024ArticleNeurology Neuroimmunology & Neuroinflammation
Successful Thrombectomy Improves Functional Outcome in Tandem Occlusions with a Large Ischemic Core
2023ArticleWorld Neurosurgery
Convergence of patient- and physician-reported outcomes in the French National Registry of Facioscapulohumeral Dystrophy
2022ArticleOrphanet Journal of Rare Diseases
Functional classification of ATM variants in ataxia‐telangiectasia patients
2019ArticleHuman Mutation
TBK1 mutation frequencies in French frontemporal dementia and amyotrophic lateral sclerosis cohorts
2015ArticleNeurobiology of Aging
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
CH COTE BASQUE
13 AV DE L'INTERNE JACQUES LOEB BP 8, 64109 BAYONNE CEDEX
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Movement disorders : official journal of the Movement Disorder Society · 2014
ABSTRACTBreathing disorders like sleep apnea, stridor, and dysrythmic breathing are frequent in patients with multiple system atrophy (MSA). These observations have been related to neurodegeneration in several pontomedullary respiratory nuclei and may explain the occurrence of sudden death. In this study, we sought to determine whether these functional and neuropathological characteristics could be replicated in a transgenic model of MSA. Mice expressing human wild‐type α‐synuclein under the control of the proteolipid promoter (PLP‐αSYN) were compared with age‐matched controls. Using whole‐body, unrestrained plethysmography, the following breathing parameters were measured: inspiratory and expiratory times, tidal volume, expiratory volume, peak inspiratory and expiratory flows, and respiratory frequency. For each category, the mean, coefficient of variation, and irregularity score were analyzed. Brains were then processed for stereological cell counts of pontomedullary respiratory nuclei. A significant increase in the coefficient of variation and irregularity score was observed for inspiratory time, tidal volume, and expiratory volume in PLP‐αSYN mice (P < 0.05). Glial cytoplasmic inclusions were found in the medullary raphe of PLP‐αSYN mice, together with a loss of serotonergic immunoreactivity in the raphe obscurus (P < 0.001) and pallidus (P < 0.01). There was a negative correlation between α‐synuclein burden and raphe pallidus cell counts (P < 0.05). There was no significant neuronal loss in the pre‐Botzinger complex. The PLP‐αSYN mouse model replicates the breathing variability and part of the neuronal depletion in pontomedullary respiratory nuclei observed in patients with MSA. Our findings support the use of this model for future candidate drugs in the breathing disorders observed in MSA. © 2014 International Parkinson and Movement Disorder Society
Movement disorders clinical practice · 2015
Abstract MSA is a progressive neurodegenerative disorder characterized by autonomic failure and a variable combination of poor levodopa‐responsive parkinsonism and cerebellar ataxia ( CA ). Current therapeutic management is based on symptomatic treatment. Almost one third of MSA patients may benefit from l ‐dopa for the symptomatic treatment of parkinsonism, whereas physiotherapy remains the best therapeutic option for CA . Only midodrine and droxidopa were found to be efficient for neurogenic hypotension in double‐blind, controlled studies, whereas other symptoms of autonomic failure may be managed with off‐label treatments. To date, no curative treatment is available for MSA . Recent results of neuroprotective and ‐restorative trials have provided some hope for future advances. Considerations for future clinical trials are also discussed in this review.
Parkinsonism & related disorders · 2017
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Parkinsonism & related disorders · 2017 · Journal Article
Flabeau O, Ghorayeb I, Perez P, Maillard A, et al.
Sleep medicine · 2014 · Comparative Study
Meissner WG, Flabeau O, Perez P, Taillard J, et al.
Movement disorders clinical practice · 2015 · Journal Article
Perez-Lloret S, Flabeau O, Fernagut PO, Pavy-Le Traon A, et al.
Movement disorders : official journal of the Movement Disorder Society · 2013 · Case Reports
Duval F, Flabeau O, Razafimahefa J, Spampinato U, et al.
Annals of clinical and translational neurology · 2026 · Journal Article
Makrygianni M, Pagan C, Citterio-Quentin A, Rouvet I, et al.
Movement disorders : official journal of the Movement Disorder Society · 2014 · Journal Article
Flabeau O, Meissner WG, Ozier A, Berger P, et al.