📇 Rhumatologue · ST MAUR DES FOSSES · (94) · Libéral

M RUDY FISCHER

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Auteur de référence en rhumatologie
25 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
134 rhumatos / 100 000 hab. — département bien doté

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📍 ST MAUR DES FOSSES (94)LibéralRPPS 10100582021

✨ Génération du profil synthétique IA en cours…

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Top publications · les plus citées

Intra-articular corticosteroid for knee osteoarthritis

The Cochrane database of systematic reviews · 2015

📚 385 citations🎯 RCR 19.65Top 1% NIH🔓 Open Access📄 PDF gratuit ↗

2021 DORIS definition of remission in SLE: final recommendations from an international task force

Lupus science & medicine · 2021

📚 297 citations🎯 RCR 23.19Top 1% NIH🔓 Open Access📄 PDF gratuit ↗

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Objective To achieve consensus on a definition of remission in SLE (DORIS). Background Remission is the stated goal for both patient and caregiver, but consensus on a definition of remission has been lacking. Previously, an international task force consisting of patient representatives and medical specialists published a framework for such a definition, without reaching a final recommendation. Methods Several systematic literature reviews were performed and specific research questions examined in suitably chosen data sets. The findings were discussed, reformulated as recommendations and voted on. Results Based on data from the literature and several SLE-specific data sets, a set of recommendations was endorsed. Ultimately, the DORIS Task Force recommended a single definition of remission in SLE, based on clinical systemic lupus erythematosus disease activitiy index (SLEDAI)=0, Evaluator’s Global Assessment <0.5 (0–3), prednisolone 5 mg/day or less, and stable antimalarials, immunosuppressives, and biologics. Conclusion The 2021 DORIS definition of remission in SLE is recommended for use in clinical care, education, and research including clinical trials and observational studies.

Periodontal disease: A systemic condition

Periodontology 2000 · 2024

📚 116 citations🎯 RCR 32.99Top 0% NIH🔓 Open Access📄 PDF gratuit ↗

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AbstractFor decades, periodontitis has been considered to be a local inflammatory disease of the periodontal tissues in the oral cavity. Initially, associations of periodontitis with a multitude of noncommunicable diseases were each studied separately, and relationships were shown. The associations of periodontitis with morbidities, such as cardiovascular diseases, rheumatoid arthritis, diabetes mellitus, respiratory diseases, have been demonstrated. As most such studies were cross‐sectional in nature, questions about causality cannot be univocally answered. And periodontitis as an independent risk factor for one systemic disease, becomes even more difficult to assess since recently periodontitis has also been associated with multimorbidity. Periodontitis and many systemic diseases share environmental, lifestyle and genetic risk factors, and share immunopathology. Moreover, suffering from one common noncommunicable disease may increase the susceptibility for another such chronic disease; the systemic effects of one condition may be one of various risk factors for another such disease. The overarching effect of any systemic disease is it causing a pro‐inflammatory state in the individual; this has also been shown for periodontitis. Moreover, in periodontitis a prothrombotic state and elevated immunological activity have been shown. As such, when we consider periodontal disease as another systemic disease, it can affect the susceptibility and progression of other systemic diseases, and importantly, vice versa. And with this, it is not surprising that periodontitis is associated with a variety of other noncommunicable diseases. The medical definition of a systemic disease includes diseases that affect different organs and systems. Thus, the aim of this opinion paper is to propose that periodontitis should be considered a systemic disease in its own right and that it affects the individual's systemic condition and wellbeing. The dental and medical profession and researchers alike, should adapt this paradigm shift, advancing periodontal disease out of its isolated anatomical location into the total of chronic noncommunicable diseases, being for some conditions a comorbid disease and, vice versa, comorbidities can affect initiation and progression of periodontal disease.

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M RUDY FISCHER

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Top publications · les plus citées

Publications scientifiques (25) — classées par pathologie

Transversal11

Lupus5

Arthrite juvénile3

Génétique2

AINS1

Anti-TNF1

Corticothérapie1

Essai clinique1

Revue / méta-analyse1

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