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MME MARTINE FILDERMAN-ADDA

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Auteur de référence en rhumatologie
50 articles scientifiques publiés — un praticien à la pointe de la recherche

Rhumatologue

RPPS 10001218303

✨ Génération du profil synthétique IA en cours…

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Top publications · les plus citées

Phylogenomic discordance suggests polytomies along the backbone of the large genus Solanum

American journal of botany · 2022

📚 59 citations🎯 RCR 6.44Top 5% NIH🔓 Open Access📄 PDF gratuit ↗

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Abstract Premise Evolutionary studies require solid phylogenetic frameworks, but increased volumes of phylogenomic data have revealed incongruent topologies among gene trees in many organisms both between and within genomes. Some of these incongruences indicate polytomies that may remain impossible to resolve. Here we investigate the degree of gene‐tree discordance in Solanum , one of the largest flowering plant genera that includes the cultivated potato, tomato, and eggplant, as well as 24 minor crop plants. Methods A densely sampled species‐level phylogeny of Solanum is built using unpublished and publicly available Sanger sequences comprising 60% of all accepted species (742 spp.) and nine regions (ITS, waxy , and seven plastid markers). The robustness of this topology is tested by examining a full plastome dataset with 140 species and a nuclear target‐capture dataset with 39 species of Solanum (Angiosperms353 probe set). Results While the taxonomic framework of Solanum remained stable, gene tree conflicts and discordance between phylogenetic trees generated from the target‐capture and plastome datasets were observed. The latter correspond to regions with short internodal branches, and network analysis and polytomy tests suggest the backbone is composed of three polytomies found at different evolutionary depths. The strongest area of discordance, near the crown node of Solanum , could potentially represent a hard polytomy. Conclusions We argue that incomplete lineage sorting due to rapid diversification is the most likely cause for these polytomies, and that embracing the uncertainty that underlies them is crucial to understand the evolution of large and rapidly radiating lineages.

Effectiveness of psychological interventions delivered by physiotherapists in the management of neck pain: a systematic review with meta-analysis

Pain reports · 2023

📚 19 citations🎯 RCR 4.87Top 8% NIH🔓 Open Access

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Abstract Physiotherapists are increasingly using psychological treatments for musculoskeletal conditions. We assessed the effects of physiotherapist-delivered psychological interventions on pain, disability, and quality of life in neck pain. We evaluated quality of intervention reporting. We searched databases for randomized controlled trials (RCTs) comprising individuals with acute or chronic whiplash-associated disorder (WAD) or nontraumatic neck pain (NTNP), comparing physiotherapist-delivered psychological interventions to standard care or no treatment. Data were extracted regarding study characteristics and outcomes. Standardised mean difference (SMD) was calculated by random-effects meta-analysis. We evaluated certainty of evidence using Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) and intervention reporting using TIDieR. Fourteen RCTs (18 articles—4 detail additional outcome/follow-up data) were included comprising 2028 patients, examining acute WAD (n = 4), subacute/mixed NTNP (n = 3), chronic WAD (n = 2), and chronic NTNP (n = 5). Treatment effects on pain favoured psychological interventions in chronic NTNP at short-term (SMD −0.40 [95% CI −0.73, −0.07]), medium-term (SMD −0.29 [95% CI −0.57, 0.00]), and long-term (SMD −0.32 [95% CI −0.60, −0.05]) follow-up. For disability, effects favoured psychological interventions in acute WAD at short-term follow-up (SMD −0.39 [95% CI −0.72, −0.07]) and chronic NTNP at short-term (SMD −0.53 [95% CI −0.91, −0.15]), medium-term (SMD −0.49 [95% CI −0.77, −0.21]), and long-term (SMD −0.60 [95% CI −0.94, −0.26]) follow-up. GRADE ratings were typically moderate, and intervention reporting often lacked provision of trial materials and procedural descriptions. Psychological interventions delivered by physiotherapists were more effective than standard physiotherapy for chronic NTNP (small-to-medium effects) and, in the short term, acute WAD.

Protective effects of milk thistle (Sylibum marianum) seed oil and α-tocopherol against 7β-hydroxycholesterol-induced peroxisomal alterations in murine C2C12 myoblasts: Nutritional insights associated with the concept of pexotherapy

Steroids · 2022

📚 17 citations🎯 RCR 2.00

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MME MARTINE FILDERMAN-ADDA

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Top publications · les plus citées

Publications scientifiques (50) — classées par pathologie

Transversal29

Arthrite juvénile2

Case report / série2

Épidémiologie & registres2

Santé mentale / fatigue2

Cervicalgie1

csDMARDs1

Essai clinique1

Génétique1

JAK inhibiteurs1

Lombalgie1

Lupus1

Maladie à IgG41

Pédiatrie1

Qualité de vie / PROMs1

Revue générale1

Sjögren1

Vascularites1

Vascularites des gros vaisseaux1

Vraie vie / RWE1

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