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2 raisons identifiées
Praticien-chercheur
16 articles scientifiques publiés — formation continue solide
Expérience confirmée
37 ans d'exercice en rhumatologie — recul clinique solide
37ans d'exercice (thèse 1989)
✨ Génération du profil synthétique IA en cours…
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Direction : Michel Riboulot
Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.
Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Nature communications · 2021
Abstract The functional annotation of livestock genomes is crucial for understanding the molecular mechanisms that underpin complex traits of economic importance, adaptive evolution and comparative genomics. Here, we provide the most comprehensive catalogue to date of regulatory elements in the pig ( Sus scrofa ) by integrating 223 epigenomic and transcriptomic data sets, representing 14 biologically important tissues. We systematically describe the dynamic epigenetic landscape across tissues by functionally annotating 15 different chromatin states and defining their tissue-specific regulatory activities. We demonstrate that genomic variants associated with complex traits and adaptive evolution in pig are significantly enriched in active promoters and enhancers. Furthermore, we reveal distinct tissue-specific regulatory selection between Asian and European pig domestication processes. Compared with human and mouse epigenomes, we show that porcine regulatory elements are more conserved in DNA sequence, under both rapid and slow evolution, than those under neutral evolution across pig, mouse, and human. Finally, we provide biological insights on tissue-specific regulatory conservation, and by integrating 47 human genome-wide association studies, we demonstrate that, depending on the traits, mouse or pig might be more appropriate biomedical models for different complex traits and diseases.
Journal of leukocyte biology · 1997
Abstract Monocyte chemoattractant protein-1 (MCP-1) attracts monocytes, memory T lymphocytes, and natural killer (NK) cells in vitro. Its expression has been documented in disorders characterized by mononuclear cell infiltrates, suggesting that it may contribute to the inflammatory component of such diseases as atherosclerosis, multiple sclerosis, or rheumatoid arthritis. To prove a causal association, the in vivo properties of MCP-1 must be understood. Several lines of transgenic mice have been constructed to address this question. A transgenic line in which MCP-1 expression is controlled by the MMTV-LTR expressed high levels of MCP-1 in multiple organs but showed no evidence for monocyte infiltration. Instead, these mice were more susceptible to infection by the intracellular pathogens, Listeria monocytogenes and Mycobacterium tuberculosis. These mice had high serum levels of MCP-1, suggesting that their circulating monocytes may have been desensitized or that MCP-1 stimulated a Th2-dominant response. In contrast, another model in which MCP-1 expression was controlled by the insulin promoter demonstrated a monocytic infiltrate in pancreatic islets. These results indicate that MCP-1 expression at low levels in an anatomically confined area results in monocyte infiltration, suggesting that when properly expressed, MCP-1's in vitro properties are reproduced in vivo. This justifies the examination of MCP-1-deficient mice in disease models in order to explore MCP-1's role in pathogenesis.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Molecular syndromology · 2025 · Journal Article
Alsuwaidi S, Ernst C
Frontiers in genetics · 2021 · Journal Article
Tixier-Boichard M, Fabre S, Dhorne-Pollet S, Goubil A, et al.
Molecular syndromology · 2016 · Review
Bell S, Kolobova I, Crapper L, Ernst C
Gene · 2015 · Journal Article
Wang Y, Zhao Y, Li J, Liu H, et al.
Frontiers in genetics · 2012 · Journal Article
Arceo ME, Ernst CW, Lunney JK, Choi I, et al.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2010 · Journal Article
Andersen T, Christensen FB, Langdahl BL, Ernst C, et al.
Genetics · 2008 · Journal Article
Cardoso FF, Rosa GJ, Steibel JP, Ernst CW, et al.
The Journal of nutrition · 2004 · Comparative Study
Martínez MM, Hill GM, Link JE, Raney NE, et al.
Animal biotechnology · 2002 · Journal Article
Yao J, Coussens PM, Saama P, Suchyta S, et al.
Journal of leukocyte biology · 1997 · Journal Article
Gu L, Rutledge B, Fiorillo J, Ernst C, et al.
Arztliche Wochenschrift · 1957 · Journal Article
ERNST C, SCHONFELD H
Nature communications · 2021 · Journal Article
Pan Z, Yao Y, Yin H, Cai Z, et al.
Frontiers in genetics · 2019 · Journal Article
Rexroad C, Vallet J, Matukumalli LK, Reecy J, et al.
BMC genomics · 2019 · Journal Article
Velez-Irizarry D, Casiro S, Daza KR, Bates RO, et al.
Acta orthopaedica · 2006 · Comparative Study
Juul O, Sigmundsson FG, Ovesen O, Andersen MO, et al.
Gene Expression Profiling in Hepatic Tissue of Newly Weaned Pigs Fed Pharmacological Zinc and Phytase Supplemented Diets
Additional file 1: of Genome-wide identification of tissue-specific long non-coding RNA in three farm animal species
Sequences of Chicken LncRNAs. A fasta file containing all the lncRNA sequences from chickens. (FA 34950 kb)
Additional file 20: of Genome-wide identification of tissue-specific long non-coding RNA in three farm animal species
Conserved LncRNAs. The 39 groups of orthologous genes across all five species are listed with the associated lncRNAs. Human and mouse lncRNA IDs are NCBI transcript IDs. (XLSX 21 kb)
Supplemental Material for Funkhouser et al., 2020
Supplemental Methods contain additional method details not in manuscript. Figure S1 contains LD decay statistics. Figure S2 contains simulation results for the discovery of any observed causal variant (whether they affec
Supplemental Material for Funkhouser et al., 2020
Supplemental Methods contain additional method details not in manuscript. Figure S1 contains LD decay statistics. Figure S2 contains simulation results for the discovery of any observed causal variant (whether they affec
Additional file 3: of Genome-wide identification of tissue-specific long non-coding RNA in three farm animal species
Sequences of Pig LncRNAs. A fasta file containing all the lncRNA sequences from pigs. (FA 21227 kb)
Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).
BMC genomics · 2018 · Journal Article
Kern C, Wang Y, Chitwood J, Korf I, et al.