📇 Rhumatologue · CORBIE · (80) · Salarié

M ABDELMOULA ELKHALKI

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2 raisons identifiées

Auteur de référence en rhumatologie
50 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
126 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 CORBIE (80)SalariéRPPS 10001845907

✨ Génération du profil synthétique IA en cours…

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CH CORBIE
33 R GAMBETTA BP 3, 80800 CORBIE
☎ 0322964000Activité de soin et de pharmacie🏥 Centre CH ↗

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Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).

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Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

The gut-eye axis: the retinal/ocular degenerative diseases and the emergent therapeutic strategies

Frontiers in cellular neuroscience · 2024

📚 23 citations🎯 RCR 5.02Top 8% NIH🔓 Open Access📄 PDF gratuit ↗

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The interplay between human microbiota and various physiological systems has garnered significant attention in recent years. The gut microbiota plays a critical role in maintaining physiological homeostasis and influences various aspects of human health, particularly via the gut brain axis. Since 2017, the challenging concept of the gut-retina axis has emerged thanks to a network analysis emphasizing the potential role of the gut microbiota disruption in the development of the age-related macular degeneration and further retinal damages. Many other ocular disorders have been linked to the dysbiosis of the gut microbiota, including uveitis and glaucoma. It has been shown that age related macular degeneration can be prevented or reversed using a diet that induces changes in the gut microbiota. The potential link between the gut microbiota as well as others types of microbiota such as the ocular surface microbiota and the development/progression of age related as well as inherited retinal degenerations and other degenerative eye diseases, has recently been broadened. Therefore, the pathogenesis of several eye diseases has recently been associated with a larger perception called the gut eye axis. This mini-review examines the potential mechanisms underlying the gut eye axis and suggests implications for the management of eye diseases. By understanding the modulation of the gut microbiota and its impact on eye disease, this mini-review provides insight into potential therapeutic interventions and avenues for future research.

Inflammation dynamically regulates steroid hormone metabolism and action within macrophages in rheumatoid arthritis

Journal of autoimmunity · 2024

📚 14 citations🎯 RCR 3.73Top 12% NIH🔓 Open Access

Gut mycobiome and neuropsychiatric disorders: insights and therapeutic potential

Frontiers in cellular neuroscience · 2024

📚 12 citations🎯 RCR 5.18🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

BackgroundThe human gut mycobiome, a minor but integral component of the gut microbiome, has emerged as a significant player in host homeostasis and disease development. While bacteria have traditionally been the focus of gut microbiome studies, recent evidence suggests that fungal communities (mycobiota) may also play a crucial role in modulating health, particularly in neuropsychiatric disorders.ObjectiveThis review aims to provide a comprehensive overview of current knowledge on the relationship between the gut mycobiome and neuropsychiatric disorders, exploring the potential of targeting fungal communities as a novel therapeutic strategy.MethodsWe summarized recent findings from metagenomic analyses that characterize the diversity and composition of gut mycobiota and discuss how these communities interact with the host and other microorganisms via the gut-brain axis. Key methodologies for studying mycobiota, such as high-throughout sequencing and bioinformatics approaches, were also reviewed to highlight advances in the field.ResultsEmerging research links gut mycobiota dysbiosis to conditions such as schizophrenia, Alzheimer’s disease, autism spectrum disorders, bipolar disorder, and depression. Studies indicate that specific fungal populations, such as Candida and Saccharomyces, may influence neuroinflammation, gut permeability and immune responses, thereby affecting mental health outcomes.ConclusionUnderstanding the gut mycobiome’s role in neuropsychiatric disorders opens new avenues for therapeutic interventions, including antifungal treatments, probiotics, and dietary modifications. Future research should integrate multi-omics approaches to unravel the complex interkingdom interactions within the gut ecosystem, paving the way for personalized medicine in mental health care.

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M ABDELMOULA ELKHALKI

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Top publications · les plus citées

Publications scientifiques (50) — classées par pathologie

Transversal28

Revue générale7

Épidémiologie & registres5

Revue / méta-analyse5

Pharmacovigilance4

Case report / série3

Lombalgie2

Anti-IL-231

Arthrite juvénile1

Biomarqueurs / Auto-Ac1

csDMARDs1

Ostéoporose1

Qualité de vie / PROMs1

Tendinopathies & SCC1

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