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5 raisons identifiées
Plateau technique de référence
Centre hospitalier universitaire (CHU) — équipements et expertise pointus pour les cas complexes
Encadrant universitaire
Forme la prochaine génération de rhumatologues (1 thèse dirigée)
Praticien-chercheur
17 articles scientifiques publiés — formation continue solide
Expérience confirmée
23 ans d'exercice en rhumatologie — recul clinique solide
Délais de RDV courts dans la région
126 rhumatos / 100 000 hab. — département bien doté
23ans d'exercice (thèse 2003)
✨ Génération du profil synthétique IA en cours…
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.
Source theses.fr — signal de direction d'équipe / statut PU-PH (à confirmer via le site universitaire).
Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.
Influence scientifique
39
39 articles ont été cités au moins 39fois par d'autres chercheurs — preuve que ses travaux sont repris par la communauté médicale.
h-index
Total citations reçues
5 033
Nombre de fois où d'autres équipes ont mentionné ses publications dans leurs propres travaux.
Publications totales
154
Articles, revues et chapitres référencés dans les bases académiques internationales.
Articles influents
67
Publications ayant marqué leur domaine — chacune citée au moins 10 fois par d'autres chercheurs.
i10-index
Thématiques principales
Affiliations FR : Centre Hospitalier Universitaire Amiens-Picardie · Université de Picardie Jules Verne
Source : OpenAlex (CC0, OurResearch). Indicateurs académiques agrégés sur 250 M+ d'œuvres.
Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.
Metabolic acidosis causes a Fanconi-like syndrome with intracellular trafficking defects and proximal tubule dysfunction
2026ArticleScience Translational Medicine
Renal ammonium ion production and transport
2026Chapitre
Renal ion-translocating ATPases
2026Chapitre
Expert Perspectives on Incorporating GLP-1 RA in Diabetes and Chronic Kidney Disease – Challenges and Opportunities
2025ArticleEuropean Journal of Preventive Cardiology
Urinary sodium wasting and disrupted collecting duct function in mice with distal renal tubular acidosis mutations
2025ArticleDisease Models & Mechanisms
Pendrin: linking acid base to blood pressure
2023ArticlePflügers Archiv European Journal of Physiology
Leave NOSTONE unturned: are thiazides useless in preventing kidney stone recurrence ?
2023ArticleKidney International
ClC-K Kidney Chloride Channels: From Structure to Pathology
2023Chapitre
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
CHU AMIENS SUD
1 RPT PROFESSEUR CHRISTIAN CABROL, 80054 AMIENS CEDEX 1
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
BMJ (Clinical research ed.) · 2015
Proceedings of the National Academy of Sciences of the United States of America · 2011
The heteromeric inwardly rectifying Kir4.1/Kir5.1 K + channel underlies the basolateral K + conductance in the distal nephron and is extremely sensitive to inhibition by intracellular pH. The functional importance of Kir4.1/Kir5.1 in renal ion transport has recently been highlighted by mutations in the human Kir4.1 gene ( KCNJ10 ) that result in seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SeSAME)/epilepsy, ataxia, sensorineural deafness, and renal tubulopathy (EAST) syndrome, a complex disorder that includes salt wasting and hypokalemic alkalosis. Here, we investigated the role of the Kir5.1 subunit in mice with a targeted disruption of the Kir5.1 gene ( Kcnj16 ). The Kir5.1 −/− mice displayed hypokalemic, hyperchloremic metabolic acidosis with hypercalciuria. The short-term responses to hydrochlorothiazide, an inhibitor of ion transport in the distal convoluted tubule (DCT), were also exaggerated, indicating excessive renal Na + absorption in this segment. Furthermore, chronic treatment with hydrochlorothiazide normalized urinary excretion of Na + and Ca 2+ , and abolished acidosis in Kir5.1 −/− mice. Finally, in contrast to WT mice, electrophysiological recording of K + channels in the DCT basolateral membrane of Kir5.1 −/− mice revealed that, even though Kir5.1 is absent, there is an increased K + conductance caused by the decreased pH sensitivity of the remaining homomeric Kir4.1 channels. In conclusion, disruption of Kcnj16 induces a severe renal phenotype that, apart from hypokalemia, is the opposite of the phenotype seen in SeSAME/EAST syndrome. These results highlight the important role that Kir5.1 plays as a pH-sensitive regulator of salt transport in the DCT, and the implication of these results for the correct genetic diagnosis of renal tubulopathies is discussed.
BMC nephrology · 2012
AbstractBackgroundSickle cell disease (SCD) leads to tissue hypoxia resulting in chronic organ dysfunction including SCD associated nephropathy. The goal of our study was to determine the best equation to estimate glomerular filtration rate (GFR) in SCD adult patients.MethodsWe conducted a prospective observational cohort study. Since 2007, all adult SCD patients in steady state, followed in two medical departments, have had their GFR measured using iohexol plasma clearance (gold standard). The Cockcroft-Gault, MDRD-v4, CKP-EPI and finally, MDRD and CKD-EPI equations without adjustment for ethnicity were tested to estimate GFR from serum creatinine. Estimated GFRs were compared to measured GFRs according to the graphical Bland and Altman method.ResultsSixty-four SCD patients (16 men, median age 27.5 years [range 18.0-67.5], 41 with SS-genotype were studied. They were Sub-Saharan Africa and French West Indies natives and predominantly lean (median body mass index: 22 kg/m2[16-33]). Hyperfiltration (defined as measured GFR >110 mL/min/1.73 m2) was detected in 53.1% of patients. Urinary albumin/creatinine ratio was higher in patients with hyperfiltration than in patients with normal GFR (4.05 mg/mmol [0.14-60]versus0.4 mg/mmol [0.7-81], p = 0.01). The CKD-EPI equation without adjustment for ethnicity had both the lowest bias and the greatest precision. Differences between estimated GFRs using the CKP-EPI equation and measured GFRs decreased with increasing GFR values, whereas it increased with the Cockcroft-Gault and MDRD-v4 equations.ConclusionsWe confirm that SCD patients have a high rate of glomerular hyperfiltration, which is frequently associated with microalbuminuria or macroalbuminuria. In non-Afro-American SCD patients, the best method for estimating GFR from serum creatinine is the CKD-EPI equation without adjustment for ethnicity. This equation is particularly accurate to estimate high GFR values, including glomerular hyperfiltration, and thus should be recommended to screen SCD adult patients at high risk for SCD nephropathy.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Science translational medicine · 2026 · Journal Article
Hennings JC, Murthy KS, Picard N, Cabrita I, et al.
European journal of preventive cardiology · 2026 · Journal Article
Halimi JM, Fauchier L, Karras A, Amouyal C, et al.
Disease models & mechanisms · 2025 · Journal Article
Mungara P, MacNaughton K, Ullah AKMS, Essuman G, et al.
Science translational medicine · 2023 · Journal Article
Trepiccione F, Iervolino A, D'Acierno M, Siccardi S, et al.
Journal of medical genetics · 2022 · Journal Article
Cornière N, Thomson RB, Thauvin S, Villoutreix BO, et al.
Scientific reports · 2017 · Journal Article
Louet M, Bitam S, Bakouh N, Bignon Y, et al.
Transplant international : official journal of the European Society for Organ Transplantation · 2017 · Journal Article
Gaillard F, Baron S, Timsit MO, Eladari D, et al.
Physiological reports · 2015 · Editorial
Kumai Y, Eladari D
EMBO molecular medicine · 2012 · Journal Article
Hennings JC, Picard N, Huebner AK, Stauber T, et al.
Proceedings of the National Academy of Sciences of the United States of America · 2011 · Journal Article
Paulais M, Bloch-Faure M, Picard N, Jacques T, et al.
BMJ (Clinical research ed.) · 2015 · Clinical Trial
Aubert O, Kamar N, Vernerey D, Viglietti D, et al.
Bone · 2013 · Journal Article
Arlet JB, Courbebaisse M, Chatellier G, Eladari D, et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2017 · Journal Article
Trepiccione F, Soukaseum C, Baudrie V, Kumai Y, et al.
Journal of the American Society of Nephrology : JASN · 2016 · Journal Article
Alexander RT, Cordat E, Chambrey R, Dimke H, et al.
Hormone research in paediatrics · 2010 · Journal Article
Bilariki K, Anagnostou E, Masse V, Elie C, et al.
Annual review of physiology · 2012 · Journal Article
Eladari D, Chambrey R, Peti-Peterdi J
BMC nephrology · 2012 · Comparative Study
Arlet JB, Ribeil JA, Chatellier G, Eladari D, et al.