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Délais de RDV courts dans la région
126 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
CABINET DU DR MARIE-ODILE DUPONT
2 BIS RUE DE LA REPUBLIQUE, 80800 DAOURS
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Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
European journal of human genetics : EJHG · 1998
Arthritis and rheumatism · 2006
AbstractObjectiveThe IKK complex regulates NF‐κB activation, an important pathway implicated in the rheumatoid arthritis (RA) disease process. This study was undertaken to assess the efficacy of N‐(6‐chloro‐7‐methoxy‐9H‐β‐carbolin‐8‐yl)‐2‐methylnicotinamide (ML120B), a potent and selective small molecule inhibitor of IKKβ.MethodsPolyarthritis was induced in rats by injection of Freund's complete adjuvant into the hind footpad. ML120B was administered orally twice daily, either prophylactically or therapeutically. Paw volumes and body weights were measured every 2–3 days throughout the study. We assessed bone erosions by several methods: histologic evaluation, quantitative micro–computed tomography (micro‐CT) imaging analysis, and measurement of type I collagen fragments in the serum. Quantitative polymerase chain reaction was used to evaluate expression of messenger RNA for genes related to inflammation and to bone and cartilage integrity.ResultsOral administration of ML120B inhibited paw swelling in a dose‐dependent manner (median effective dosage 12 mg/kg twice daily) and offered significant protection against arthritis‐induced weight loss as well as cartilage and bone erosion. We were able to directly demonstrate that NF‐κB activity in arthritic joints was reduced after ML120B administration. Also, we observed that down‐regulation of the NF‐κB pathway via IKKβ inhibition dampened the chronic inflammatory process associated with rat adjuvant‐induced arthritis.ConclusionThe results of the present study suggest that IKKβ inhibition is an effective therapeutic approach to treat both the inflammation and the bone/cartilage destruction observed in RA. Methods for the determination of serum markers for bone and cartilage destruction, as well as micro‐CT analysis, may aid in predicting and evaluating the therapeutic efficacy of IKKβ inhibition therapy in humans.
Acta cardiologica · 2021
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Acta cardiologica · 2021 · Journal Article
Martens P, Ter Maaten JM, Vanhaen D, Heeren E, et al.
Arthritis and rheumatism · 2006 · Journal Article
Schopf L, Savinainen A, Anderson K, Kujawa J, et al.
Cahiers d'anesthesiologie · 1987 · Journal Article
Dupont M, Alessandri C, Lebré P, Rastello C
European journal of human genetics : EJHG · 1998 · Journal Article
Dewalle M, Domingo C, Rozenbaum M, Ben-Chétrit E, et al.