📇 Rhumatologue ·
Chargement de la fiche…
Chargement de la fiche…
MonRhumato.fr utilise des cookies pour mesurer l'audience (statistiques) et améliorer le site. Aucune donnée de santé identifiable n'est jamais collectée. Politique de confidentialité.
Votre choix est conservé 13 mois (durée max CNIL). Vous pouvez le modifier à tout moment via Préférences cookies.
2 raisons identifiées
Praticien-chercheur
13 articles scientifiques publiés — formation continue solide
Référence presse grand public
Cité 1 fois dans les médias — pédagogie reconnue
✨ Génération du profil synthétique IA en cours…
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).
📰 VA INFOS · 08/02/2020
<a href="https://news.google.com/rss/articles/CBMipgFBVV95cUxOY2ZUTFNBUnRUdnVnZmFhR0N5UGVkOThKOUsxMEVoTkh3WFBsVEFia3NtSDBoRm0yMUROX1ZKLWQzSlpWTUxPME1JUEV4bm5NaFRnSlJxVHhaUWd5TGRuQm5wSVl5YVBSelRpS2pxLTdyMXZtN296U3pJeDZRTFBWTl95d01jdVNNV1pndFZZNEhrT0RsNWFZM1Z1RDktRkdUY1NvNnFB?oc=5" target="_blank">Jea
Calcified tissue international · 2022
AbstractOrthogeriatrics is increasingly recommended in the care of hip fracture patients, although evidence for this model is conflicting or at least limited. Furthermore, there is no conclusive evidence on which model [geriatric medicine consultant service (GCS), geriatric medical ward with orthopedic surgeon consultant service (GW), integrated care model (ICM)] is superior. The review summarizes the effect of orthogeriatric care for hip fracture patients on length of stay (LOS), time to surgery (TTS), in-hospital mortality, 1-year mortality, 30-day readmission rate, functional outcome, complication rate, and cost. Two independent reviewers retrieved randomized controlled trials, controlled observational studies, and pre/post analyses. Random-effects meta-analysis was performed. Thirty-seven studies were included, totaling 37.294 patients. Orthogeriatric care significantly reduced LOS [mean difference (MD) − 1.55 days, 95% confidence interval (CI) (− 2.53; − 0.57)], but heterogeneity warrants caution in interpreting this finding. Orthogeriatrics also resulted in a 28% lower risk of in-hospital mortality [95%CI (0.56; 0.92)], a 14% lower risk of 1-year mortality [95%CI (0.76; 0.97)], and a 19% lower risk of delirium [95%CI (0.71; 0.92)]. No significant effect was observed on TTS and 30-day readmission rate. No consistent effect was found on functional outcome. Numerically lower numbers of complications were observed in orthogeriatric care, yet some complications occurred more frequently in GW and ICM. Limited data suggest orthogeriatrics is cost-effective. There is moderate quality evidence that orthogeriatrics reduces LOS, in-hospital mortality, 1-year mortality, and delirium of hip fracture patients and may reduce complications and cost, while the effect on functional outcome is inconsistent. There is currently insufficient evidence to recommend one or the other type of orthogeriatric care model.
Maturitas · 2019
Proceedings of the National Academy of Sciences of the United States of America · 2011
Immune suppressive activities exerted by regulatory T-cell subsets have several specific functions, including self-tolerance and regulation of adaptive immune reactions, and their dysfunction can lead to autoimmune diseases and contribute to AIDS and cancer. Two functionally distinct regulatory T-cell subsets are currently identified in peripheral tissues: thymus-developed natural T regulatory cells (nTregs) controlling self-tolerance and antiinflammatory IL-10–secreting type 1 regulatory T cells (Tr1) derived from Ag-stimulated T cells, which regulate inflammation-dependent adaptive immunity and minimize immunopathology. We establish herein that cell contact-mediated nTreg regulatory function is inhibited by inflammation, especially in the presence of the complement C3b receptor (CD46). Instead, as with other T-cell subsets, the latter inflammatory conditions of stimulation skew nTreg differentiation to Tr1 cells secreting IL-10, an effect potentiated by IFN-α. The clinical relevance of these findings was verified in a study of 152 lupus patients, in which we showed that lupus nTreg dysfunction is not due to intrinsic defects but is rather induced by C3b stimulation of CD46 and IFN-α and that these immune components of inflammation are directly associated with active lupus. These results provide a rationale for using anti–IFN-α Ab immunotherapy in lupus patients.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Current osteoporosis reports · 2025 · Journal Article
Laurent MR, Dupont J, Lemahieu W, Jamar S, et al.
Arthritis research & therapy · 2023 · Journal Article
Ruyssen-Witrand A, Guernec G, Dupont J, Lapuyade D, et al.
Maturitas · 2019 · Journal Article
Laurent MR, Dedeyne L, Dupont J, Mellaerts B, et al.
Proceedings of the National Academy of Sciences of the United States of America · 2011 · Journal Article
Le Buanec H, Gougeon ML, Mathian A, Lebon P, et al.
European journal of nuclear medicine · 1996 · Letter
Leslie WD, Thomson GT, Dupont JO, McDonald D
Annales de dermatologie et de venereologie · 1983 · English Abstract
Noyon G, Blanc D, Kienzler JL, Laurent R, et al.
Acta clinica Belgica · 2023 · Journal Article
Konings V, Laurent MR, Janssens S, Dupont J, et al.
Bone reports · 2022 · Case Reports
Dupont J, Appermans W, Dejaeger M, Wauters I, et al.
Joint bone spine · 2020 · Case Reports
Dupont J, Laurent MR, Dedeyne L, Luyten FP, et al.
Calcified tissue international · 2022 · Journal Article
Van Heghe A, Mordant G, Dupont J, Dejaeger M, et al.
International journal of technology assessment in health care · 2018 · Journal Article
Guillon M, Rochaix L, Dupont JK
Bone · 2026 · Journal Article
Gielen E, Amini N, Coppens D, Dejaeger M, et al.
International journal of technology assessment in health care · 2018 · Journal Article
Guillon M, Rochaix L, Dupont JK
International journal of technology assessment in health care · 2018 · Journal Article
Guillon M, Rochaix L, Dupont JK
Virchows Archiv : an international journal of pathology · 2007 · Case Reports
Hoppé E, de Ybarlucéa LR, Collet J, Dupont J, et al.
Calcified tissue international · 2022 · Journal Article
Van Heghe A, Mordant G, Dupont J, Dejaeger M, et al.
Virchows Archiv : an international journal of pathology · 2007 · Case Reports
Hoppé E, de Ybarlucéa LR, Collet J, Dupont J, et al.