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5 raisons identifiées
Auteur de référence en rhumatologie
22 articles scientifiques publiés — un praticien à la pointe de la recherche
Encadrant universitaire
Forme la prochaine génération de rhumatologues (1 thèse dirigée)
En plein centre-ville
PARIS (75002) — accessible depuis tout le bassin urbain
Référence presse grand public
Cité 2 fois dans les médias — pédagogie reconnue
Délais de RDV courts dans la région
336.2 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Source theses.fr — signal de direction d'équipe / statut PU-PH (à confirmer via le site universitaire).
Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.
Extended disorder at the cell surface: The conformational landscape of the ectodomains of syndecans
2021ArticleMatrix Biology Plus
A comparative analysis of secreted protein disulfide isomerases from the tropical co-endemic parasites Schistosoma mansoni and Leishmania major
2019ArticleScientific Reports
Insights into the structure and dynamics of lysyl oxidase propeptide, a flexible protein with numerous partners
2018ArticleScientific Reports
A Eukaryotic-like Serine/Threonine Kinase Protects Staphylococci against Phages
2016ArticleCell Host and Microbe
The Extended Conformation of the 2.9-Å Crystal Structure of the Three-PASTA Domain of a Ser/Thr Kinase from the Human Pathogen Staphylococcus aureus
2010ArticleJournal of Molecular Biology
Crystallization and initial X-ray diffraction study of the three PASTA domains of the Ser/Thr kinase Stk1 from the human pathogen Staphylococcus aureus
2009ArticleActa Crystallographica Section F: Structural Biology and Crystallization Communications
Characterization of a Serine/Threonine Kinase Involved in Virulence of Staphylococcus aureus
2009ArticleJournal of Bacteriology
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
MEDADOM MEDICAL
139 BD DE SEBASTOPOL, 75002 PARIS
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).
📰 Ouest-France · 09/12/2013
<a href="https://news.google.com/rss/articles/CBMiuAFBVV95cUxQMEhPend5VnVkYW02eC1WNlh2X3BjaE9RVGZjVFlxWktZTTVmWHNrc1RVSG00OEY2bWZPbDVwUmJzUU1LSW5laGdFLVFoLWFlNU5lX0VINlhYZmFVNFFfdU5lRVBQM0NEVGF4bWwzYnQyMms1Vjd5WXZUZFRJR0REMFlrQWluR0RvRjctU1dvRlRFa0VkN2hKQzBGNFN6d05KUkloLXM3RmY1YjV0Q0xzOUcxTlJuOUs3?o
📰 Ouest-France · 05/12/2012
<a href="https://news.google.com/rss/articles/CBMingFBVV95cUxOcDVvNjByTXM0ZmhoV2FKc1ZWMXZMTFhHaEZwQlZNN3hnbmdMS3Byd3NKYUJSVmVyU1hFYXY1dVlIYzVyQ3FvNm1wOEc0N2s0VWFvZnNVV2JwUklvOE5iZGk0XzVnOXYzS2dycjFBZk1QLXBFTzhZWUR5TzYxd1h4dVZiZmFrVXREckM3QjBwdTJ2T28tZW5LTEdPV21iQQ?oc=5" target="_blank">Les sapeurs-p
Journal of bacteriology · 2009
ABSTRACT Staphylococcus aureus is a common human cutaneous and nasal commensal and a major life-threatening pathogen. Adaptation to the different environments encountered inside and outside the host is a crucial requirement for survival and colonization. We identified and characterized a eukaryotic-like serine/threonine kinase with three predicted extracellular PASTA domains (SA1063, or Stk1) and its associated phosphatase (SA1062, or Stp1) in S. aureus . Biochemical analyses revealed that Stk1 displays autokinase activity on threonine and serine residues and is localized to the membrane. Stp1 is a cytoplasmic protein with manganese-dependent phosphatase activity toward phosphorylated Stk1. In-frame deletions of the stk1 and stp1 genes were constructed in S. aureus strain 8325-4. Phenotypic analyses of the mutants revealed reduced growth of the stk1 mutant in RPMI 1640 defined medium that was restored when adenine was added to the medium. Furthermore, the stk1 mutant displayed increased resistance to Triton X-100 and to fosfomycin, suggesting modifications in cell wall metabolism. The stk1 mutant was tested for virulence in a mouse pyelonephritis model and found to be strongly reduced for survival in the kidneys (approximately 2-log-unit decrease) compared to the parental strain. Renal histopathological analyses showed severe inflammatory lesions in mice infected with the parental S. aureus SH1000 strain, whereas the Δ stk1 mutant led to only minimal renal lesions. These results confirm the important role of Stk1 for full expression of S. aureus pathogenesis and suggest that phosphorylation levels controlled by stk1 are essential in controlling bacterial survival within the host.
Arthritis and rheumatism · 2003
AbstractObjectiveArthritis in the K/BxN mouse model results from pathogenic immunoglobulins that recognize glucose‐6‐phosphate isomerase (GPI), a glycolytic enzyme residing in the cytoplasm of all cells. Antibodies directed against GPI can, alone, transfer arthritis to healthy recipients. Previous experiments have revealed significant titers of anti‐GPI antibodies in the serum of many patients with rheumatoid arthritis (RA). We evaluated the generality of these observations in cohorts of patients with 12 different arthritic and chronic autoimmune diseases and in population‐matched healthy control subjects.MethodsAnti‐GPI antibodies were assayed in 811 individual serum samples by enzyme‐linked immunosorbent assay with 2 forms of GPI, recombinant and native. Results were confirmed by immunoblotting.ResultsSeveral patients had significantly elevated anti‐GPI antibody titers, but without the prevalence or the specificity reported previously. Only 15% of RA patients had anti‐GPI antibodies (range 12–29% in different cohorts), with a higher prevalence in patients with active disease. Psoriatic arthritis, undifferentiated arthritis, and spondylarthropathy patients also displayed anti‐GPI antibodies at similar frequencies (12–25%). Similar titers were detected in a proportion (5–10%) of control subjects or patients with Crohn's disease or sarcoidosis. Very high titers were found in rare cases of RA and systemic lupus erythematosus.ConclusionNo disease‐specific pattern of antibody positivity to GPI was apparent. While the antibody‐mediated mechanism at play in the mouse model may exemplify a generic mechanism for some forms of arthritis in humans, GPI itself does not appear to be a target common to the majority of RA patients.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Matrix biology plus · 2021 · Journal Article
Gondelaud F, Bouakil M, Le Fèvre A, Miele AE, et al.
ACS medicinal chemistry letters · 2021 · Journal Article
Subramanian G, Duclos B, Johnson PD, Williams T, et al.
Scientific reports · 2019 · Journal Article
Miele AE, Badaoui S, Maugliani L, Salza R, et al.
Scientific reports · 2018 · Journal Article
Vallet SD, Miele AE, Uciechowska-Kaczmarzyk U, Liwo A, et al.
Journal of medicinal chemistry · 2018 · Journal Article
Vazquez ML, Kaila N, Strohbach JW, Trzupek JD, et al.
Journal of veterinary pharmacology and therapeutics · 2017 · Journal Article
Duclos BA, Rugg CA, White J, Ross JT, et al.
Cell host & microbe · 2016 · Journal Article
Depardieu F, Didier JP, Bernheim A, Sherlock A, et al.
Biochimica et biophysica acta · 2013 · Journal Article
Peysselon F, Launay G, Lisacek F, Duclos B, et al.
Journal of molecular biology · 2010 · Journal Article
Paracuellos P, Ballandras A, Robert X, Kahn R, et al.
Journal of bacteriology · 2010 · Journal Article
Cluzel ME, Zanella-Cléon I, Cozzone AJ, Fütterer K, et al.
FEMS microbiology letters · 2010 · Journal Article
Didier JP, Cozzone AJ, Duclos B
Acta crystallographica. Section F, Structural biology and crystallization communications · 2009 · Journal Article
Paracuellos P, Ballandras A, Robert X, Cozzone AJ, et al.
Journal of bacteriology · 2009 · Journal Article
Débarbouillé M, Dramsi S, Dussurget O, Nahori MA, et al.
Analytical biochemistry · 2008 · Journal Article
Lomas-Lopez R, Cozzone AJ, Duclos B
FEMS microbiology letters · 2007 · Journal Article
Lomas-Lopez R, Paracuellos P, Riberty M, Cozzone AJ, et al.
The Journal of biological chemistry · 2006 · Journal Article
Soulat D, Jault JM, Duclos B, Geourjon C, et al.
Microbiology (Reading, England) · 2004 · Journal Article
Preneta R, Papavinasasundaram KG, Cozzone AJ, Duclos B
Archives of microbiology · 2004 · Journal Article
Cozzone AJ, Grangeasse C, Doublet P, Duclos B
Journal of bacteriology · 2002 · Journal Article
Soulat D, Vaganay E, Duclos B, Genestier AL, et al.
Arthritis and rheumatism · 2003 · Journal Article
Matsumoto I, Lee DM, Goldbach-Mansky R, Sumida T, et al.
Digestive diseases and sciences · 1994 · Journal Article
Chamouard P, Grunebaum L, Wiesel ML, Freyssinet JM, et al.
Gastroenterologie clinique et biologique · 1987 · Case Reports
Duclos B, Baumann R, Sondag D, Jouin H, et al.