📇 Rhumatologue · VERNON · (27) · Libéral
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4 raisons identifiées
Praticien-chercheur
6 articles scientifiques publiés — formation continue solide
Référence presse grand public
Cité 1 fois dans les médias — pédagogie reconnue
Disponibilité géographique
2 lieux d'exercice — choisissez celui qui vous arrange
Délais de RDV courts dans la région
63.9 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
CABINET DU DR ARNAUD DUCHEZ
IMMEUBLE LES IMPRESSIONNISTES 1 A RUE DE LA PROCESSION, 27200 VERNON
HOPITAL GUSTAVE FLAUBERT CH LE HAVRE
55 B R GUSTAVE FLAUBERT BP 24, 76083 LE HAVRE CEDEX
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📰 Paris Normandie · 07/03/2026
<a href="https://news.google.com/rss/articles/CBMizwFBVV95cUxPLVBMSXFiRlUtVzhTMy1jNkg2TmF2NlFXSEIzelhxUTI0N3kydEhPUk16eDk2Sm9iY29UZ3VJV1BVdGFFbTVNNjBmRENmcElicnNMSlcybWpQRkRjdWxEM1dmUEF2Y2FFMVdrNUd6N21mdVY3NDZId1BrVkNaYm5FYlBFZlRaQW8tT0NhWTV3eWlwWllDb2o0OFJ1UjJ5VDlaOEY1ZnB3R19sM3pmTGd0NEFHbnhHVFloT3
Proceedings of the National Academy of Sciences of the United States of America · 2015
Significance On activation, blood platelets package components from their cytoplasm into microparticles (MPs), tiny vesicles released by cytoplasmic membrane budding and shedding. Given that MPs can impact other cellular lineages on internalization, we aimed to decipher the mechanisms promoting MP internalization by cellular recipients. We modeled MP internalization by neutrophils and identified a predominant lipid, 12(S)-hydroxyeicosatetranoic acid, as a mediator critical for the promotion of MP internalization. MPs were found inside neutrophils from individuals with rheumatoid arthritis, and their presence in neutrophils in the joints of mice treated with arthritogenic serum is dependent on the expression of enzymes implicated in the generation of 12(S)-hydroxyeicosatetranoic acid. These findings reveal a unique molecular mechanism implicated in MP internalization relevant to inflammatory processes.
Scientific reports · 2016
AbstractExtracellular vesicles (EV) are small membrane vesicles produced by cells upon activation and apoptosis. EVs are heterogeneous according to their origin, mode of release, membrane composition, organelle and biochemical content, and other factors. Whereas it is apparent that EVs are implicated in intercellular communication, they can also be used as biomarkers. Continuous improvements in pre-analytical parameters and flow cytometry permit more efficient assessment of EVs; however, methods to more objectively distinguish EVs from cells and background, and to interpret multiple single-EV parameters are lacking. We used spanning-tree progression analysis of density-normalized events (SPADE) as a computational approach for the organization of EV subpopulations released by platelets and erythrocytes. SPADE distinguished EVs, and logically organized EVs detected by high-sensitivity flow cytofluorometry based on size estimation, granularity, mitochondrial content, and phosphatidylserine and protein receptor surface expression. Plasma EVs were organized by hierarchy, permitting appreciation of their heterogeneity. Furthermore, SPADE was used to analyze EVs present in the synovial fluid of patients with inflammatory arthritis. Its algorithm efficiently revealed subtypes of arthritic patients based on EV heterogeneity patterns. Our study reveals that computational algorithms are useful for the analysis of high-dimensional single EV data, thereby facilitating comprehension of EV functions and biomarker development.
JCI insight · 2022
Secreted phospholipase A 2 -IIA (sPLA 2 -IIA) hydrolyzes phospholipids to liberate lysophospholipids and fatty acids. Given its poor activity toward eukaryotic cell membranes, its role in the generation of proinflammatory lipid mediators is unclear. Conversely, sPLA 2 -IIA efficiently hydrolyzes bacterial membranes. Here, we show that sPLA 2 -IIA affects the immune system by acting on the intestinal microbial flora. Using mice overexpressing transgene-driven human sPLA 2 -IIA, we found that the intestinal microbiota was critical for both induction of an immune phenotype and promotion of inflammatory arthritis. The expression of sPLA 2 -IIA led to alterations of the intestinal microbiota composition, but housing in a more stringent pathogen-free facility revealed that its expression could affect the immune system in the absence of changes to the composition of this flora. In contrast, untargeted lipidomic analysis focusing on bacteria-derived lipid mediators revealed that sPLA 2 -IIA could profoundly alter the fecal lipidome. The data suggest that a singular protein, sPLA 2 -IIA, produces systemic effects on the immune system through its activity on the microbiota and its lipidome.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Lupus science & medicine · 2022 · Journal Article
Hasse S, Julien AS, Duchez AC, Zhao C, et al.
Biochemical pharmacology · 2021 · Journal Article
Hasse S, Duchez AC, Fortin P, Boilard E, et al.
Prostaglandins & other lipid mediators · 2019 · Journal Article
Duchez AC, Boudreau LH, Naika GS, Rousseau M, et al.
Scientific reports · 2016 · Journal Article
Marcoux G, Duchez AC, Cloutier N, Provost P, et al.
Proceedings of the National Academy of Sciences of the United States of America · 2015 · Journal Article
Duchez AC, Boudreau LH, Naika GS, Bollinger J, et al.
JCI insight · 2022 · Journal Article
Doré E, Joly-Beauparlant C, Morozumi S, Mathieu A, et al.