M GABRIEL DUCHESNE

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Top publications · les plus citées

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  Impact of androgen suppression and zoledronic acid on bone mineral density and fractures in the Trans-Tasman Radiation Oncology Group (TROG) 03.04 Randomised Androgen Deprivation and Radiotherapy (RADAR) randomized controlled trial for locally advanced prostate cancer

  BJU international · 2014

  📚 25 citations🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

  Lire l'abstract Crossref ↓

  Objective To study the influence of adjuvant androgen suppression and bisphosphonates on incident vertebral and non‐spinal fracture rates and bone mineral density ( BMD ) in men with locally advanced prostate cancer. Patients and Methods Between 2003 and 2007, 1071 men with locally advanced prostate cancer were randomly allocated, using a 2 × 2 trial design, to 6 months i.m. leuprorelin (androgen suppression [ AS ]) before radiotherapy alone ± 12 months additional leuprorelin ± 18 months zoledronic acid ( ZdA ), commencing at randomization. The main endpoint was incident thoraco‐lumbar vertebral fractures, which were assessed radiographically at randomization and at 3 years, then reassessed by centralized review. Subsidiary endpoints included incident non‐spinal fractures, which were documented throughout follow‐up, and BMD , which was measured in 222 subjects at baseline, 2 years and 4 years. Results Incident vertebral fractures at 3 years were observed in 132 subjects. Their occurrence was not increased by 18 months’ AS , nor reduced by ZdA . Incident non‐spinal fractures occurred in 72 subjects and were significantly related to AS duration but not to ZdA . Osteopenia and osteoporosis prevalence rates at baseline were 23.4 and 1.4%, respectively, at the hip. Treatment for 6 and 18 months with AS caused significant reductions in hip BMD at 2 and 4 years ( P < 0.01) and ZdA prevented these losses at both time points. Conclusion In an AS ‐naïve population, 18 months of ZdA treatment prevented the sustained BMD losses caused by 18 months of AS treatment; however, the study power was insufficient to show that AS duration or ZdA influenced vertebral fracture rates.

Publications scientifiques (1) — classées par pathologie

Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).

Datasets & protocoles partagés

• From heteroclinic loops to homoclinic snaking in reversible systems: rigorous forcing through computer-assisted proofs

  Preprint2025arXiv

  Homoclinic snaking is a widespread phenomenon observed in many pattern-forming systems. Demonstrating its occurrence in non-perturbative regimes has proven difficult, although a forcing theory has been developed based on

• Rigorous computer-assisted methods for global structures in dynamical systems

  Dissertation2026McGill University

  This thesis presents three research articles that advance the field of rigorous computer-assisted proofs (CAPs) in nonlinear dynamical systems, with a particular focus on validating complex solution structures in partial

• Computer-assisted proofs for a nonlinear Laplace-Beltrami equation on the sphere

  Dissertation2019McGill University

  Lessard, Jean-Philippe (Supervisor)

Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).

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