📇 Rhumatologue ·
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Praticien-chercheur
18 articles scientifiques publiés — formation continue solide
✨ Génération du profil synthétique IA en cours…
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International journal of molecular sciences · 2021
Bone is a multi-skilled tissue, protecting major organs, regulating calcium phosphate balance and producing hormones. Its development during childhood determines height and stature as well as resistance against fracture in advanced age. Estrogens are key regulators of bone turnover in both females and males. These hormones play a major role in longitudinal and width growth throughout puberty as well as in the regulation of bone turnover. In women, estrogen deficiency is one of the major causes of postmenopausal osteoporosis. In this review, we will summarize the main clinical and experimental studies reporting the effects of estrogens not only in females but also in males, during different life stages. Effects of estrogens on bone involve either Estrogen Receptor (ER)α or ERβ depending on the type of bone (femur, vertebrae, tibia, mandible), the compartment (trabecular or cortical), cell types involved (osteoclasts, osteoblasts and osteocytes) and sex. Finally, we will discuss new ongoing strategies to increase the benefit/risk ratio of the hormonal treatment of menopause.
Genes · 2020
Cystic fibrosis (CF) is a genetic disease with mutational changes leading to profound dysbiosis, both pulmonary and intestinal, from a very young age. This dysbiosis plays an important role in clinical manifestations, particularly in the lungs, affected by chronic infection. The range of microbiological tools has recently been enriched by metagenomics based on next-generation sequencing (NGS). Currently applied essentially in a gene-targeted manner, metagenomics has enabled very exhaustive description of bacterial communities in the CF lung niche and, to a lesser extent, the fungi. Aided by progress in bioinformatics, this now makes it possible to envisage shotgun sequencing and opens the door to other areas of the microbial world, the virome, and the archaeome, for which almost everything remains to be described in cystic fibrosis. Paradoxically, applying NGS in microbiology has seen a rebirth of bacterial culture, but in an extended manner (culturomics), which has proved to be a perfectly complementary approach to NGS. Animal models have also proved indispensable for validating microbiome pathophysiological hypotheses. Description of pathological microbiomes and correlation with clinical status and therapeutics (antibiotic therapy, cystic fibrosis transmembrane conductance regulator (CFTR) modulators) revealed the richness of microbiome data, enabling description of predictive and follow-up biomarkers. Although monogenic, CF is a multifactorial disease, and both genotype and microbiome profiles are crucial interconnected factors in disease progression. Microbiome-genome interactions are thus important to decipher.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
The American journal of tropical medicine and hygiene · 2026 · Case Reports
Henry K, Françoise U, Durand C, Salloum C, et al.
PLOS global public health · 2024 · Journal Article
Saidu Y, Masong MC, Francoise N, Ngenge BM, et al.
Journal of clinical immunology · 2022 · Letter
Françoise U, Lafont E, Suarez F, Lanternier F, et al.
International journal of molecular sciences · 2021 · Journal Article
Emmanuelle NE, Marie-Cécile V, Florence T, Jean-François A, et al.
Surgical and radiologic anatomy : SRA · 2021 · Journal Article
Jean-Philippe H, Benoît B, Françoise K, Michael D
JAMA neurology · 2020 · Journal Article
Louapre C, Collongues N, Stankoff B, Giannesini C, et al.
Drug design, development and therapy · 2019 · Journal Article
Kameoka Y, F K, M K
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026 · Journal Article
Françoise U, Nacher M, Donald SM, Van Eer M, et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025 · Journal Article
Sturny-Leclère A, Françoise U, Badjé AD, Garcia-Hermoso D, et al.
Infection · 2025 · Journal Article
Boscals de Réals Q, Françoise U, Vignier N, Delacour H, et al.
The American journal of case reports · 2025 · Journal Article
Françoise U, Henry K, Sidibe M, Lalande V, et al.
PLoS neglected tropical diseases · 2025 · Journal Article
Bourne-Watrin M, Françoise U, Baron SA, Adenis AA, et al.
Leukemia & lymphoma · 2016 · Letter
Grain A, Sirvent A, Strullu M, Françoise M, et al.
International journal of adolescent medicine and health · 2016 · Journal Article
Akoï K, Francoise JP, Aurel C, Laure-Manuella I, et al.
BMC pregnancy and childbirth · 2021 · Journal Article
Angèle MN, Abel NM, Jacques OM, Henri MT, et al.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2015 · Clinical Trial, Phase II
Rio B, Chevret S, Vigouroux S, Chevallier P, et al.
BMJ case reports · 2026 · Journal Article
F A, George OK, Alex AG, Sahitya MS
Genes · 2020 · Journal Article
Françoise A, Héry-Arnaud G