📇 Rhumatologue · PARIS · (75) · Mixte

MME SAHAR DIMITRI-DAUVERGNE

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Auteur de référence en rhumatologie
29 articles scientifiques publiés — un praticien à la pointe de la recherche
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336.2 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 PARIS (75)MixteRPPS 10001372514

✨ Génération du profil synthétique IA en cours…

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CLINIQUE DU MONT LOUIS
8-10 8 R DE LA FOLIE REGNAULT, 75011 PARIS
☎ 0143565656Activité de soin et de pharmacie
CABINET DU DR SAHAR DIMITRI-DAUVERGNE
5 RUE DU DOCTEUR LAURENT, 75013 PARIS
☎ 0145809870Activité de soin et de pharmacie

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

The gut microbiota promotes pain in fibromyalgia

Neuron · 2025

📚 26 citations🎯 RCR 10.54🔓 Open Access

Altered Gut Microbiome Composition and Function in Individuals with Complex Regional Pain Syndrome

Anesthesiology · 2025

📚 5 citations🎯 RCR 2.37

Lire l'abstract Crossref ↓

Background: Complex regional pain syndrome is a chronic pain syndrome typically affecting a limb. It is characterized by severe spontaneous and evoked pain, along with vasomotor, autonomic, and motor signs and symptoms. Although dysregulation in several physiologic systems has been suggested in complex regional pain syndrome (CRPS), including aberrant inflammatory and immune responses, vasomotor dysfunction, and nervous system changes, the pathophysiologic mechanisms underlying the syndrome remain elusive. Effective treatment options are also limited. Previous research has highlighted the role of the gut microbiome in chronic pain, prompting us to investigate the composition and function of the gut microbiome in CRPS. Methods: The gut microbiomes of individuals with CRPS to age-, sex-, and ethnicity-matched pain-free control participants were compared using 16S rRNA gene amplification. To minimize environmental confounders, participants were recruited from two geographically independent regions. To explore potential changes in gut bacteria–derived metabolites, targeted metabolomic analysis of feces and plasma was performed. Finally, machine learning algorithms were trained to identify the gut microbiome composition specific to CRPS patients and were tested on a validation cohort. Results: In this study, differential abundance analysis revealed significant differences in several bacterial taxa when comparing 53 CRPS patients to 52 unrelated controls, including alterations in short-chain fatty acid–metabolizing species. Targeted stool and plasma metabolite analysis confirmed differences in fecal and plasma short-chain fatty acid levels between CRPS patients and controls. Notably, the microbiome composition alone allowed accurate classification of patients and controls in a geographically independent test cohort. Conclusions: These findings highlight unique compositional and functional changes in the gut microbiome of individuals with CRPS, thus contributing to the growing body of evidence supporting the role of the gut microbiome in chronic pain syndromes. Furthermore, they pave the way for further studies elucidating the pathophysiology of CRPS and exploring new diagnostic aids and treatment modalities.

Impact of seasonal cycle on rheumatoid arthritis based on genetic and epigenetic mechanisms

Frontiers in immunology · 2025

📚 3 citations🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

Rheumatoid arthritis is an autoimmune disease characterized by chronic inflammation and progressive joint destruction. Genetic and environmental risk factors contribute to the development of rheumatoid arthritis (RA). Among environmental factors, seasonal cycles are reported to impact the clinical phenotypes in RA, with rheumatic flares being aggravated during the winter season. Gaining insight into the seasonal effects on molecular drivers can be vital in resolving seasonal cycles in RA pathogenesis. To understand this phenomenon, genome-wide association study (GWAS) and candidate genes were reviewed to identify their role in susceptibility to RA. Subsequently, it was verified how many of these genes are modulated by seasonal influences. Furthermore, the role of epigenetic modifications, such as DNA methylation and non-coding RNAs, involved in RA pathogenesis and whether these epigenetic effects are also impacted by seasonal fluctuation were examined. Finally, it was investigated how these genetic and epigenetic mechanisms result in the breakdown of self-tolerance and the initiation of an autoimmune action. Upon overlapping the genetic and epigenetic observations influenced by seasonal cycles, it was evident that seasonal cycles do impact the genetic and epigenetic machinery, which possibly can explain the reasons for seasonal flares in RA pathogenesis. The evidence indicates that genetic and epigenetic mechanisms are driven by climatic variation and that the timing and duration of the aberrant expression of immune response genes will drive the autoantibodies to develop seasonal flares of RA.

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MME SAHAR DIMITRI-DAUVERGNE

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Top publications · les plus citées

Publications scientifiques (29) — classées par pathologie

Transversal12

Case report / série3

Microbiote2

Pharmacovigilance2

Revue générale2

Biomarqueurs / Auto-Ac1

Économie santé1

Épidémiologie & registres1

Essai clinique1

Génétique1

IRM ostéo-articulaire1

Lupus1

Revue / méta-analyse1

Risque cardio-vasculaire1

Santé mentale / fatigue1

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