📇 Rhumatologue · CAEN · (14) · Mixte
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5 raisons identifiées
Plateau technique de référence
Centre hospitalier universitaire (CHU) — équipements et expertise pointus pour les cas complexes
Praticien-chercheur
11 articles scientifiques publiés — formation continue solide
Référence presse grand public
Cité 1 fois dans les médias — pédagogie reconnue
Disponibilité géographique
2 lieux d'exercice — choisissez celui qui vous arrange
Délais de RDV courts dans la région
150.8 rhumatos / 100 000 hab. — département bien doté
✨ Génération du profil synthétique IA en cours…
CABINET DU DR ROBERT DESPREZ
130 RUE SAINT JEAN, 14000 CAEN
CHU CAEN
AV COTE DE NACRE, 14033 CAEN CEDEX 9
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Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).
📰 Top Santé · 06/05/2014
<a href="https://news.google.com/rss/articles/CBMipAFBVV95cUxNQlp3MDdENkhZSjhOdFItRXU4VUtPN2c0QjRpWnNDX0JOX0dNWnhCeXMzYWxlVDJSZlZIR1N5WEljcVowcGt5WVBLMTY4SE4yMHlsSm9fRFhHbmZRV0NEb2ZleURpRC1obENmaDFSbkE1R2ZwaktTU0RLM3lnV0t0Yk1qanJjRWpvNHdOOWdUR0JxNFdCdmZtOVdnd1hFc1psYUhJYg?oc=5" target="_blank">Doule
Plant physiology · 2014
Abstract Plant growth and organ formation depend on the oriented deposition of load-bearing cellulose microfibrils in the cell wall. Cellulose is synthesized by a large relative molecular weight cellulose synthase complex (CSC), which comprises at least three distinct cellulose synthases. Cellulose synthesis in plants or bacteria also requires the activity of an endo-1,4-β-d-glucanase, the exact function of which in the synthesis process is not known. Here, we show, to our knowledge for the first time, that a leaky mutation in the Arabidopsis (Arabidopsis thaliana) membrane-bound endo-1,4-β-d-glucanase KORRIGAN1 (KOR1) not only caused reduced CSC movement in the plasma membrane but also a reduced cellulose synthesis inhibitor-induced accumulation of CSCs in intracellular compartments. This suggests a role for KOR1 both in the synthesis of cellulose microfibrils and in the intracellular trafficking of CSCs. Next, we used a multidisciplinary approach, including live cell imaging, gel filtration chromatography analysis, split ubiquitin assays in yeast (Saccharomyces cerevisiae NMY51), and bimolecular fluorescence complementation, to show that, in contrast to previous observations, KOR1 is an integral part of the primary cell wall CSC in the plasma membrane.
Nature communications · 2021
AbstractThe poverty of disease resistance gene reservoirs limits the breeding of crops for durable resistance against evolutionary dynamic pathogens. Zymoseptoria tritici which causes Septoria tritici blotch (STB), represents one of the most genetically diverse and devastating wheat pathogens worldwide. No fully virulent Z. tritici isolates against synthetic wheats carrying the major resistant gene Stb16q have been identified. Here, we use comparative genomics, mutagenesis and complementation to identify Stb16q, which confers broad-spectrum resistance against Z. tritici. The Stb16q gene encodes a plasma membrane cysteine-rich receptor-like kinase that was recently introduced into cultivated wheat and which considerably slows penetration and intercellular growth of the pathogen.
Molecular plant pathology · 2015
Summary Fungal plant pathogens, such as Z ymoseptoria tritici (formerly known as M ycosphaerella graminicola ), secrete repertoires of effectors to facilitate infection or trigger host defence mechanisms. The discovery and functional characterization of effectors provides valuable knowledge that can contribute to the design of new and effective disease management strategies. Here, we combined bioinformatics approaches with expression profiling during pathogenesis to identify candidate effectors of Z . tritici . In addition, a genetic approach was conducted to map quantitative trait loci ( QTL s) carrying putative effectors, enabling the validation of both complementary strategies for effector discovery. In planta expression profiling revealed that candidate effectors were up‐regulated in successive waves corresponding to consecutive stages of pathogenesis, contrary to candidates identified by QTL mapping that were, overall, expressed at low levels. Functional analyses of two top candidate effectors ( SSP15 and SSP18 ) showed their dispensability for Z . tritici pathogenesis. These analyses reveal that generally adopted criteria, such as protein size, cysteine residues and expression during pathogenesis, may preclude an unbiased effector discovery. Indeed, genetic mapping of genomic regions involved in specificity render alternative effector candidates that do not match the aforementioned criteria, but should nevertheless be considered as promising new leads for effectors that are crucial for the Z . tritici –wheat pathosystem.
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022 · Journal Article
Robert P, Goudemand E, Auzanneau J, Oury FX, et al.
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022 · Journal Article
Robert P, Auzanneau J, Goudemand E, Oury FX, et al.
Nature communications · 2021 · Journal Article
Saintenac C, Cambon F, Aouini L, Verstappen E, et al.
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2020 · Journal Article
Ollier M, Talle V, Brisset AL, Le Bihan Z, et al.
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2017 · Journal Article
Prat N, Guilbert C, Prah U, Wachter E, et al.
TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2016 · Journal Article
Kassa MT, Haas S, Schliephake E, Lewis C, et al.
Molecular plant pathology · 2015 · Journal Article
Mirzadi Gohari A, Ware SB, Wittenberg AH, Mehrabi R, et al.
Fungal genetics and biology : FG & B · 2015 · Journal Article
Ben M'Barek S, Cordewener JH, Tabib Ghaffary SM, van der Lee TA, et al.
Plant physiology · 2014 · Journal Article
Vain T, Crowell EF, Timpano H, Biot E, et al.
International journal of obesity (2005) · 2011 · Controlled Clinical Trial
Morel O, Luca F, Grunebaum L, Jesel L, et al.
Molecular breeding : new strategies in plant improvement · 2014 · Journal Article
Charmet G, Storlie E, Oury FX, Laurent V, et al.