📇 Rhumatologue · ANNECY · (74) · Salarié

MME MORINE DELCHAMBRE-ROUSSEL

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Auteur de référence en rhumatologie
37 articles scientifiques publiés — un praticien à la pointe de la recherche
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📍 ANNECY (74)SalariéRPPS 10100429371

✨ Génération du profil synthétique IA en cours…

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Top publications · les plus citées

Effect of duration of adjuvant chemotherapy with S-1 (6 versus 12 months) for resected pancreatic cancer: the multicenter clinical randomized phase II postoperative adjuvant chemotherapy S-1 (PACS-1) trial

International journal of clinical oncology · 2023

📚 6 citations🩺 Clinique

Clinical impact of myosteatosis measured by magnetic resonance imaging on long-term outcomes of hepatocellular carcinoma after radical hepatectomy

BMC surgery · 2023

📚 5 citations🔓 Open Access📄 PDF gratuit ↗

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Abstract Aims A variety of factors have been reported to affect long-term outcomes after radical resection of hepatocellular carcinoma (HCC). However, the indicators remain controversial. The purpose of this study was to evaluate the relationship between myosteatosis of the multifidus muscle and long-term outcomes after radical surgery for HCC. Methods We retrospectively analyzed clinicopathological data for 187 patients with HCC who underwent radical surgery at Tokushima University between January 2009 and December 2020 and measured the density of fat in the multifidus muscle at L3 on their preoperative magnetic resonance images (MRI). Associations of myosteatosis and clinicopathological factors with long-term outcomes were evaluated. Results The patients were divided into a myosteatosis-negative group (n = 122) and a myosteatosis-positive group (n = 65). The cancer-specific survival rate after hepatectomy was significantly worse in the myosteatosis-positive group than in the myosteatosis-negative group (p = 0.03). Univariate analysis identified multiple tumors, stage III/IV disease, an alfa-fetoprotein level ≥ 10 ng/ml, PIVKA-II ≥ 400 AU/ml, vp(+) status, and myosteatosis to be prognostic factors for cancer-specific survival. Multivariate analysis revealed multiple tumors, an alfa-fetoprotein level ≥ 10 ng/ml, and myosteatosis to be independent prognostic factors. Conclusions Myosteatosis measured by MRI is a simple and useful predictor of the long-term outcome after radical surgery for HCC.

Multiplication of tumor maximum diameter and number as a new surgical indicator for Barcelona Clinic Liver Cancer intermediate-stage hepatocellular carcinoma

Hepatology research : the official journal of the Japan Society of Hepatology · 2023

📚 5 citations🔓 Open Access📄 PDF gratuit ↗

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AbstractAimRecent advances in treatment modalities have been made, limiting the indication of hepatic resection in the treatment strategy for hepatocellular carcinoma (HCC) patients. This retrospective study investigated the significance of multiplication of tumor maximum diameter and number (MDN) as a surgical indicator for Barcelona Clinic Liver Cancer intermediate‐stage HCC.MethodsA total of 49 patients with Barcelona Clinic Liver Cancer intermediate‐stage HCC who underwent curative hepatic resection between 2000 and 2020 were enrolled in this study. Prognostic factors of overall survival and disease‐free survival, including the product of MDN, were analyzed.ResultsPatients with MDN >12 experienced significantly worse prognosis compared with those with MDN ≤12 (p = 0.0395), and 5‐year overall survival rates after hepatic resection were 60.0% and 23.4%, respectively. Furthermore, the disease‐free survival rate of patients with MDN >12 was significantly worse compared with those with MDN ≤12 (p = 0.0049), and all patients with MDN >12 experienced recurrence within 3 years after hepatic resection. In the multivariate analysis, MDN >12 was identified as the only independent prognostic factor of both overall survival and disease‐free survival. In addition, patients with MDN >12 suffered from uncontrollable recurrence by locoregional treatment, such as more than four intrahepatic and extrahepatic recurrences, after hepatic resection.ConclusionsMDN index might be a new surgical indicator for Barcelona Clinic Liver Cancer intermediate‐stage HCC, and influence clinical decision‐making for individual treatment strategies.

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MME MORINE DELCHAMBRE-ROUSSEL

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Top publications · les plus citées

Publications scientifiques (37) — classées par pathologie

Transversal19

Arthrite juvénile2

Essai clinique2

Revue générale2

csDMARDs1

Épidémiologie & registres1

Génétique1

IRM ostéo-articulaire1

Lombalgie1

Lupus1

Maladie à IgG41

Pédiatrie1

Qualité de vie / PROMs1

Vascularites1

Vascularites des gros vaisseaux1

Vraie vie / RWE1

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