📇 Rhumatologue ·
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4 raisons identifiées
Encadrant universitaire
Forme la prochaine génération de rhumatologues (6 thèses dirigées)
Praticien-chercheur
7 articles scientifiques publiés — formation continue solide
Référence presse grand public
Cité 2 fois dans les médias — pédagogie reconnue
Expérience confirmée
20 ans d'exercice en rhumatologie — recul clinique solide
20ans d'exercice (thèse 2006)
✨ Génération du profil synthétique IA en cours…
Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.
Identification d'une nouvelle population lymphocytaire T CD8 régulatrice : rôle physiopathologique et contrôle génétique
Identification of a new subset of natural CD8 regulatory T-cell : physiolopathologic analysis and genetic control
Direction : Abdelhadi Saoudi
Source : catalogue national des thèses theses.fr (ABES). Ne couvre que les doctorats / HDR — les thèses d'exercice (DES) sont archivées dans les SCD universitaires.
Les rôles d'Eomes dans les lymphocytes T au cours de la neuro-inflammation et de la réponse anti-tumorale
2025Doctorant·e : Cindy Peillex
Rôle du facteur de transcription Eomes dans la modulation de la réponse antitumorale des lymphocytes T au cours de la thérapie ciblant 4-1BB
2023Doctorant·e : Arantxa Agesta
Rôles du facteur de transcription Eomes dans les fonctions, le métabolisme et la survie des LT CD4 dans un modèle murin de sclérose en plaques
2022Doctorant·e : Emeline Joulia
Rôles des facteurs de transcription Foxo3 et Eomes dans la différenciation et les fonctions des lymphocytes T CD4
2018Doctorant·e : Michael Michieletto
Rôle de Themis dans l'homéostasie du système immunitaire et intestinale
2011Doctorant·e : Marianne Chabod
Rôle du facteur de transcription Eomes dans la réponse des LT à l’immunothérapie dans le mélanome
Doctorant·e : Chloe Ferrand
Source theses.fr — signal de direction d'équipe / statut PU-PH (à confirmer via le site universitaire).
Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.
Chemical inhibition of SUMOylation activates the FSHD locus
2026ArticleScientific Reports
Transient pharmacological inhibition of SUMOylation during pregnancy induces craniofacial malformations in offspring mice
2025ArticleEuropean Journal of Cell Biology
Pierre Tiollais (1934-2024), un pionnier du génie génétique et une vie consacrée au virus de l’hépatite B
2025ArticleMédecine/Sciences
Biographical Feature: In memoriam Pierre Tiollais (1934–2024)
2025ArticleJournal of Virology
SUMO operates from a unique long tandem repeat to keep innate immunity in check
2025ArticleNucleic Acids Research
Cell shape sensing licenses dendritic cells for homeostatic migration to lymph nodes
2024ArticleNature Immunology
Generation of embryo-like structures from mouse embryonic stem cells treated with a chemical inhibitor of SUMOylation and cultured in microdroplets
2023ArticleSTAR Protocols
C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress–Induced Ferroptosis in FLT3 -Mutant Leukemia
2023ArticleCancer Discovery
Source : HAL — archive ouverte CCSD/CNRS (couvre articles, chapitres EMC, communications congrès, thèses).
Secteur de conventionnement non disponible (médecin hospitalier ou non présent dans l'Annuaire santé CNAM des libéraux conventionnés).
Lien Doctolib = recherche Google site:doctolib.fr (le 1er résultat est presque toujours le profil correct s'il existe).
Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).
📰 Sud Ouest · 05/03/2020
<a href="https://news.google.com/rss/articles/CBMiiwFBVV95cUxONmc1UTR3dUdxRWgxZWRDVXo2MUp3WmctWVlrZkN3U3JCNlRraE5aaklrYlJjaXp3MW5scFF6b2FWQ1FfbUcyRVF4alBCMTNKRVpmOEJwR1loczdTUEdrLVV3SVY2Ri02bTVpak5jYmNEeXBCcmxHVUtXY2o5M0NIQlJJR1pmb2JKc1Uw?oc=5" target="_blank">Guy Pustelnik présente sa liste</a> <fo
📰 Les Podcasts de l'Institut · 30/09/2012
<a href="https://news.google.com/rss/articles/CBMivgFBVV95cUxNbGkxWjdNbnR1MVNzTlVkMk1hclhNVmx1RmhJanIzeUJVVmM3Zm11ZXJkZmpzSGZNR0d2dXNneWlPaWZXbFY1V0VidjdMS3VJRmJhMGptUFBzRElNWlFuYjh5YzdXYW4wYjNmMEJnUW1hWUFOclZ1TWpMQkdIdjZBczM0N1h3eG5JQXVpOGEtbUh4LUFjcGNSSHJZMGZpdVFDLTlGaVdFak9ISUE2cTN0V2s1N3NpVlFlam
Genome research · 2013
Despite numerous studies on specific sumoylated transcriptional regulators, the global role of SUMO on chromatin in relation to transcription regulation remains largely unknown. Here, we determined the genome-wide localization of SUMO1 and SUMO2/3, as well as of UBC9 (encoded by UBE2I) and PIASY (encoded by PIAS4), two markers for active sumoylation, along with Pol II and histone marks in proliferating versus senescent human fibroblasts together with gene expression profiling. We found that, whereas SUMO alone is widely distributed over the genome with strong association at active promoters, active sumoylation occurs most prominently at promoters of histone and protein biogenesis genes, as well as Pol I rRNAs and Pol III tRNAs. Remarkably, these four classes of genes are up-regulated by inhibition of sumoylation, indicating that SUMO normally acts to restrain their expression. In line with this finding, sumoylation-deficient cells show an increase in both cell size and global protein levels. Strikingly, we found that in senescent cells, the SUMO machinery is selectively retained at histone and tRNA gene clusters, whereas it is massively released from all other unique chromatin regions. These data, which reveal the highly dynamic nature of the SUMO landscape, suggest that maintenance of a repressive environment at histone and tRNA loci is a hallmark of the senescent state. The approach taken in our study thus permitted the identification of a common biological output and uncovered hitherto unknown functions for active sumoylation at chromatin as a key mechanism that, in dynamically marking chromatin by a simple modifier, orchestrates concerted transcriptional regulation of a network of genes essential for cell growth and proliferation.
Scientific reports · 2018
AbstractIn Peru, hepatocellular carcinoma (HCC) arises in young non-cirrhotic patients. Hepatitis B virus (HBV) is suspected to be the prominent etiological agent. We thus performed a comprehensive molecular study of HBV infection in 65 Peruvian HCC patients. Only 51% were considered as persistently infected at the onset. HBV DNA was found by PCR in the tumor and/or matched non-tumor liver tissues in more than 80% of cases (n = 53/65). HBV DNA was significantly more abundant in livers of younger patients than in those of the older ones. We consistently observed low viral DNA burden (0.1–6.5 copies for 100 cells), with viral genomes in younger patients displaying higher proportion of mutations at di-pyrimidines (TpT and CpC, P = 0.006). A drastic activation of multiple DNA repair pathways in tumors of younger patients was observed. Our observations clearly challenge the current vision that associates high HBV DNA load with earlier tumor development. We concluded that in Peru, and maybe in other populations with Americas’ indigenous ancestry, HBV-associated liver tumorigenesis might differ significantly from that generally observed in the rest of the world. Procedures used to screen for HCC development in subjects at risk should be adapted to the local situation.
Molecular cancer · 2015
Source PubMed · Recherche par auteur (homonymes possibles, vérifier l'affiliation).
Medecine sciences : M/S · 2025 · Historical Article
Bréchot C, Charnay P, de Thé H, Dejean A, et al.
Neurology(R) neuroimmunology & neuroinflammation · 2024 · Journal Article
Morandi E, Adoue V, Bernard I, Friebel E, et al.
Molecular cancer · 2015 · Journal Article
Rebbani K, Marchio A, Ezzikouri S, Afifi R, et al.
Genome research · 2013 · Journal Article
Neyret-Kahn H, Benhamed M, Ye T, Le Gras S, et al.
The Journal of experimental medicine · 2024 · Journal Article
Joulia E, Michieletto MF, Agesta A, Peillex C, et al.
Journal of immunology (Baltimore, Md. : 1950) · 2015 · Journal Article
Pedros C, Gaud G, Bernard I, Kassem S, et al.
Scientific reports · 2018 · Journal Article
Marchio A, Cerapio JP, Ruiz E, Cano L, et al.
Seurat objects relative to the single-cell RNA sequencing analysis of the study "4-1BB immunotherapy reveals the Eomes dependency of exhausted CD4+ T cell lineage maintenance and function in anti-tumor immunity" by Arantxa Agesta and co-authors."
merged_clusterd_seurat_without_Tregs_with_TcR_info.rds: this seurat v5 object contains mouse CD4 CD44hi T cells sorted from the spleen of mice harbouring myeloma-like tumors (Vk*myc) and treated with an agonistic anti-4
Seurat objects relative to the single-cell RNA sequencing analysis of the study "4-1BB immunotherapy reveals the Eomes dependency of exhausted CD4+ T cell lineage maintenance and function in anti-tumor immunity" by Arantxa Agesta and co-authors."
merged_clusterd_seurat_without_Tregs_with_TcR_info.rds: this seurat v5 object contains mouse CD4 CD44hi T cells sorted from the spleen of mice harbouring myeloma-like tumors (Vk*myc) and treated with an agonistic anti-4
Source : DataCite — DOIs pour datasets, logiciels, protocoles, registres patient. Hors articles (déjà couverts).