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MME MARIE-CHRISTINE DEBON-CHEVALIER

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Auteur de référence en rhumatologie
32 articles scientifiques publiés — un praticien à la pointe de la recherche

Rhumatologue

RPPS 10002121951

✨ Génération du profil synthétique IA en cours…

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Top publications · les plus citées

Phase IV postmarketing surveillance study shows continued efficacy and safety of Stempeucel in patients with critical limb ischemia due to Buerger's disease

Stem cells translational medicine · 2021

📚 17 citations🎯 RCR 1.35🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

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Abstract Buerger's disease or thromboangiitis obliterans is a type of obstructive vascular diseases categorized as vasculitis and usually present in 95% of young smoker men. The main pathogenetic mechanism is interplay between immune system and inflammation. Earlier our phase II study has shown that Stempeucel is safe when injected at 2 million cells/kg body weight by virtue of its anti-inflammatory, immunomodulatory, and angiogenetic properties. The present study was conducted to further assess the safety and efficacy of Stempeucel in critical limb ischemia due to Buerger's disease after obtaining approval from Indian FDA based on the data generated in the phase II study. This is an open label, multicenteric phase IV PMS study conducted across India with experienced vascular surgeons. Fifty patients of critical limb ischemia due to Buerger's disease with Rutherford III-5 or III-6 were included in the study and each individual received a dose of 2 million cells/kg body weight of Stempeucel in the calf muscles and around the ulcer. These patients were evaluated over 12 months from drug administration. The present study showed the continued long term efficacy over a period of 12 months follow up in these patients corroborating the result obtained in the previous phase II studies. There was significant improvement in rest pain, ankle systolic pressure, and ankle brachial pressure index with accelerated ulcer healing. In conclusion, the present study shows that the intramuscular administration of Stempeucel continues to be safe, tolerable, and effective alternative treatment in patients with Buerger's disease.

An Evaluation of Efficacy and Safety of Tofacitinib, A JAK Inhibitor in the Management of Hospitalized Patients with Mild to Moderate COVID-19 - An Open-Label Randomized Controlled Study

The Journal of the Association of Physicians of India · 2022

📚 16 citations🎯 RCR 1.11🩺 Clinique

The role of pain and walking difficulties in shaping willingness to undergo joint surgery for osteoarthritis: Data from the Swedish BOA register

Osteoarthritis and cartilage open · 2021

📚 8 citations🔓 Open Access

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MME MARIE-CHRISTINE DEBON-CHEVALIER

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Top publications · les plus citées

Publications scientifiques (32) — classées par pathologie

Transversal8

Arthrite juvénile2

JAK inhibiteurs2

Pédiatrie2

Revue générale2

Vascularites des gros vaisseaux2

Vraie vie / RWE2

Case report / série1

csDMARDs1

Économie santé1

Épidémiologie & registres1

Essai clinique1

Génétique1

Lombalgie1

Lupus1

Maladie à IgG41

Qualité de vie / PROMs1

Sjögren1

Tendinopathies & SCC1

Vascularites1

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