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MME Sylvie DE LOMBARES-GUILLON

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Auteur de référence en rhumatologie
38 articles scientifiques publiés — un praticien à la pointe de la recherche

Rhumatologue

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✨ Génération du profil synthétique IA en cours…

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Top publications · les plus citées

Identification of the gene for oral-facial-digital type I syndrome

American journal of human genetics · 2001

📚 249 citations🎯 RCR 4.59Top 9% NIH🔓 Open Access📄 PDF gratuit ↗

New neurons in the vestibular nuclei complex after unilateral vestibular neurectomy in the adult cat

The European journal of neuroscience · 2007

📚 69 citations🎯 RCR 1.85

Lire l'abstract Crossref ↓

AbstractRecent findings revealed a reactive neurogenesis after lesions and in several models of disease. After unilateral vestibular neurectomy (UVN), we previously reported γ‐aminobutyric acid (GABA)ergic neurons are upregulated in the vestibular nuclei (VN) in the adult cat. Here, we ask whether this upregulation of GABAergic neurons resulted from a reactive neurogenesis. To determine the time course of cell proliferation in response to UVN, 5‐bromo‐2′‐deoxyuridine (BrdU) was injected 3 h, 1, 3, 7, 15 and 30 days after UVN. We investigated the survival and differentiation in UVN cats injected with BrdU at 3 days and perfused 30 days after UVN. Results show a high number of BrdU‐immunoreactive nuclei in the deafferented VN with a peak at 3 days after UVN and a decrease at 30 days. Most of the newly generated cells survived up to 1 month after UVN and gave rise to a variety of cell types. Confocal analysis revealed three cell lineages: microglial cells (OX 42/BrdU‐immunoreactive cells); astrocytes [glial fibrillary acidic protein (GFAP)/BrdU‐immunoreactive cells]; and neurons (NeuN/BrdU‐immunoreactive cells). That UVN induced new neurons was confirmed by an additional marker (nestin) expressed by neural precursor cells. We show that most of the newly generated neurons have a GABAergic phenotype [glutamate decarboxylase (GAD)‐67/BrdU‐immunoreactive cells]. Morphological analysis showed two subtypes of GABAergic neurons: medium and small (30 vs. 10 µm, respectively). This is the first report of reactive neurogenesis in the deafferented VN in the adult mammalian CNS.

Molecular toxicity of methotrexate in rheumatoid arthritis treatment: A novel perspective and therapeutic implications

Toxicology · 2021

📚 43 citations🎯 RCR 3.63Top 12% NIH

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MME Sylvie DE LOMBARES-GUILLON

Pourquoi vous devez consulter ce praticien

Lieu de consultation

Tarifs & secteur de conventionnement

Prendre rendez-vous & contact

Top publications · les plus citées

Publications scientifiques (38) — classées par pathologie

Transversal29

Pédiatrie2

Biomarqueurs / Auto-Ac1

Case report / série1

csDMARDs1

Économie santé1

Essai clinique1

Génétique1

Lupus1

Pharmacovigilance1

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