📇 Rhumatologue · CREIL CEDEX 1 · (60) · Salarié

MME CARINE DAVOUX

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Auteur de référence en rhumatologie
30 articles scientifiques publiés — un praticien à la pointe de la recherche
Délais de RDV courts dans la région
73.1 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 CREIL CEDEX 1 (60)SalariéRPPS 10001849222

✨ Génération du profil synthétique IA en cours…

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CTRE PREVENTION & EXAMENS SANTE
13 R RIBOT BP 201, 60313 CREIL CEDEX 1
☎ 0344617033Activité non soignante

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Top publications · les plus citées

Cardamine hirsuta: a versatile genetic system for comparative studies

The Plant journal : for cell and molecular biology · 2014

📚 70 citations🎯 RCR 2.11Top 25% NIH🔓 Open Access📄 PDF gratuit ↗

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SummaryA major goal in biology is to identify the genetic basis for phenotypic diversity. This goal underpins research in areas as diverse as evolutionary biology, plant breeding and human genetics. A limitation for this research is no longer the availability of sequence information but the development of functional genetic tools to understand the link between changes in sequence and phenotype. Here we describe Cardamine hirsuta, a close relative of the reference plant Arabidopsis thaliana, as an experimental system in which genetic and transgenic approaches can be deployed effectively for comparative studies. We present high‐resolution genetic and cytogenetic maps for C. hirsuta and show that the genome structure of C. hirsuta closely resembles the eight chromosomes of the ancestral crucifer karyotype and provides a good reference point for comparative genome studies across the Brassicaceae. We compared morphological and physiological traits between C. hirsuta and A. thaliana and analysed natural variation in stamen number in which lateral stamen loss is a species characteristic of C. hirsuta. We constructed a set of recombinant inbred lines and detected eight quantitative trait loci that can explain stamen number variation in this population. We found clear phylogeographic structure to the genetic variation in C. hirsuta, thus providing a context within which to address questions about evolutionary changes that link genotype with phenotype and the environment.

Longitudinal monitoring of SARS-CoV-2 in wastewater using viral genetic markers and the estimation of unconfirmed COVID-19 cases

The Science of the total environment · 2022

📚 47 citations🎯 RCR 4.73Top 8% NIH🔓 Open Access

Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update

Polymers · 2020

📚 46 citations🎯 RCR 3.66Top 12% NIH🔓 Open Access📄 PDF gratuit ↗

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An optimal host–microbiota interaction in the human vagina governs the reproductive health status of a woman. The marked depletion in the beneficial Lactobacillus sp. increases the risk of infection with sexually transmitted pathogens, resulting in gynaecological issues. Vaginal infections that are becoming increasingly prevalent, especially among women of reproductive age, require an effective concentration of antimicrobial drugs at the infectious sites for complete disease eradication. Thus, topical treatment is recommended as it allows direct therapeutic action, reduced drug doses and side effects, and self-insertion. However, the alterations in the physiological conditions of the vagina affect the effectiveness of vaginal drug delivery considerably. Conventional vaginal dosage forms are often linked to low retention time in the vagina and discomfort which significantly reduces patient compliance. The lack of optimal prevention and treatment approaches have contributed to the unacceptably high rate of recurrence for vaginal diseases. To combat these limitations, several novel approaches including nano-systems, mucoadhesive polymeric systems, and stimuli-responsive systems have been developed in recent years. This review discusses and summarises the recent research progress of these novel approaches for vaginal drug delivery against various vaginal diseases. An overview of the concept and challenges of vaginal infections, anatomy and physiology of the vagina, and barriers to vaginal drug delivery are also addressed.

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MME CARINE DAVOUX

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Top publications · les plus citées

Publications scientifiques (30) — classées par pathologie

Transversal11

Case report / série6

Lupus4

Épidémiologie & registres2

Génétique2

Revue générale2

Corticothérapie1

Gériatrie1

Pédiatrie1

Pharmacovigilance1

SAPL1

Vascularites des gros vaisseaux1

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