📇 Rhumatologue · MUIZON · (51) · Libéral

M Jean-Marie COCHEPIN

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Auteur de référence en rhumatologie
21 articles scientifiques publiés — un praticien à la pointe de la recherche
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134.8 rhumatos / 100 000 hab. — département bien doté

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📍 MUIZON (51)LibéralRPPS 10001712891

✨ Génération du profil synthétique IA en cours…

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Top publications · les plus citées

Ill Effects and Complications Associated to Removable Dentures With Improper Use and Poor Oral Hygiene: A Systematic Review

Cureus · 2022

📚 11 citations🎯 RCR 1.83🔓 Open Access📄 PDF gratuit ↗

Prospect of Alpha-Synuclein (A-Syn) Isolation From Saliva as a Promising Diagnostic Biomarker Alternative in Parkinson's Disease (PD): A Systematic Review

Cureus · 2022

📚 8 citations🔓 Open Access📄 PDF gratuit ↗

Genome-Wide Mutant Screening in Yeast Reveals that the Cell Wall is a First Shield to Discriminate Light From Heavy Lanthanides

Frontiers in microbiology · 2022

📚 8 citations🔓 Open Access

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The rapidly expanding utilization of lanthanides (Ln) for the development of new technologies, green energies, and agriculture has raised concerns regarding their impacts on the environment and human health. The absence of characterization of the underlying cellular and molecular mechanisms regarding their toxicity is a caveat in the apprehension of their environmental impacts. We performed genomic phenotyping and molecular physiology analyses of Saccharomyces cerevisiae mutants exposed to La and Yb to uncover genes and pathways affecting Ln resistance and toxicity. Ln responses strongly differed from well-known transition metal and from common responses mediated by oxidative compounds. Shared response pathways to La and Yb exposure were associated to lipid metabolism, ion homeostasis, vesicular trafficking, and endocytosis, which represents a putative way of entry for Ln. Cell wall organization and related signaling pathways allowed for the discrimination of light and heavy Ln. Mutants in cell wall integrity-related proteins (e.g., Kre1p, Kre6p) or in the activation of secretory pathway and cell wall proteins (e.g., Kex2p, Kex1p) were resistant to Yb but sensitive to La. Exposure of WT yeast to the serine protease inhibitor tosyl phenylalanyl chloromethyl ketone mimicked the phenotype of kex2∆ under Ln, strengthening these results. Our data also suggest that the relative proportions of chitin and phosphomannan could modulate the proportion of functional groups (phosphates and carboxylates) to which La and Yb could differentially bind. Moreover, we showed that kex2∆, kex1∆, kre1∆, and kre6∆ strains were all sensitive to light Ln (La to Eu), while being increasingly resistant to heavier Ln. Finally, shotgun proteomic analyses identified modulated proteins in kex2∆ exposed to Ln, among which several plasmalemma ion transporters that were less abundant and that could play a role in Yb uptake. By combining these different approaches, we unraveled that cell wall components not only act in Ln adsorption but are also active signal effectors allowing cells to differentiate light and heavy Ln. This work paves the way for future investigations to the better understanding of Ln toxicity in higher eukaryotes.

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M Jean-Marie COCHEPIN

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Top publications · les plus citées

Publications scientifiques (21) — classées par pathologie

Revue générale6

Revue / méta-analyse5

Transversal5

Case report / série2

Biomarqueurs / Auto-Ac1

Biothérapies non-anti-TNF1

Essai clinique1

Génétique1

Lupus1

Santé mentale / fatigue1

SAPL1

Sclérodermie1

Sjögren1

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