📇 Rhumatologue · MONTPELLIER · (34) · Libéral

MME Valerie COCHEN-DE COCK

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4 raisons identifiées

Auteur de référence en rhumatologie
45 articles scientifiques publiés — un praticien à la pointe de la recherche
Référence presse grand public
Cité 5 fois dans les médias — pédagogie reconnue
Disponibilité géographique
2 lieux d'exercice — choisissez celui qui vous arrange
Délais de RDV courts dans la région
153.9 rhumatos / 100 000 hab. — département bien doté

Rhumatologue

📍 MONTPELLIER (34)LibéralRPPS 10001601417

📊 Reconnaissance scientifique : 41/100📝 168 articles publiés🇫🇷 Publications académiques françaises (8)

✨ Génération du profil synthétique IA en cours…

Activité de recherche & publications

Indicateurs publics agrégés sur 250 M+ d'œuvres scientifiques (OpenAlex, PubMed). Traduits ici en langage patient.

Influence scientifique

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Articles de presse (5)

Source : Google News (recherche par nom complet — homonymes possibles, vérifier le contenu).

Maladie de Parkinson : à Montpellier, on se soigne en rythme et en musique - Midi Libre

📰 Midi Libre · 10/04/2021

<a href="https://news.google.com/rss/articles/CBMiuwFBVV95cUxOaFZLWGNzZnd6cFl2MElHbVVhbjBYai1QeU5ZY1JqQWlhWWhCUGNTbU9GMHVGNHY3Wk56NFBsQVZuQnpKTF9GY2d6QjhqMzFwUXV0WUVJa3lfa0dBWXMtSGpPVGpBTzNLWEgtMUFwdlRSWFBNYnFkay1sSkxGc2ZCbjBVaG5KTGswR0VyUDhEczF5VU5lNE1FMUhXRHByVnV2OFhpTEhXenV1OTl5bURhcDF1OWdGR0pGX3

Efficacité de la pompe à apomorphine chez des personnes atteintes de maladie de Parkinson se plaignant d'une insomnie sévère - AP-HP Assistance publique - Hôpitaux de Paris

📰 AP-HP Assistance publique - Hôpitaux de Paris · 10/02/2025

<a href="https://news.google.com/rss/articles/CBMiugFBVV95cUxOdHM5MzcyRExzWnNNUTBMajh5SEV0NWZyOTdZSTZsV2pMcGhybVlSV3ZZNnZ2U1F4S01QUE1ZN01sbGRFX2ZibVFHTFhuOVk4U0xoSng4RnFTb1dmbVc0alBuemdWbl9YbHZoR19JUENvZnpWWFVQOHVQaEdUMWk2ZFc4Rkh4ZEdVRWlLT3lXODNDeW5tMjdmNDNDOXVfaGFEdzA2RjMyMzZ6Ny00RWJUOU1iaG5kZlZ2Q3

Parkinson : ces patients mystérieusement « guéris » pendant leurs rêves - Alternative Santé

📰 Alternative Santé · 24/03/2021

<a href="https://news.google.com/rss/articles/CBMimgFBVV95cUxQYjZ4cDNNU1BaZjA5SUdfRHNLTWZlQ0tSbFhIYXgxTnVuV0FxSHYtLVlyUGVUOHJXLVR6azAtdXVsTkV5RnNwQXh3NXhKSlA3Y2NhS2E5U1ZFYklHNkpobUhUOXJLZ2szeXp5SFNGLVVRT1o5Qk81WFhIbWtxRDdJWGJkaXdPczVkXzVQNHltaU9TM2xXSENlTWV3?oc=5" target="_blank">Parkinson : ces pat

"Une mauvaise nuit, c'est une journée horrible" : les troubles du sommeil en question, ce jeudi soir, à Montpellier - Midi Libre

📰 Midi Libre · 25/01/2023

<a href="https://news.google.com/rss/articles/CBMi7AFBVV95cUxQbTR1QkdqbzM0RmlYTDJsR2htV0NoSVFvRFVfajUwNEFDd010WGctUFRIb1c3bE91YmVmLTdfS2M2M2x0d19zcDM5Uk5ROFdUYU9rdWg2bFpWaVVBQjRFSTdrR3o5aEx4cWdlVW9ZNklwb0ZrbzNLeGZMTE9YNXJCQmRtUk9VQlNkdTdYaEI1SWtYeEUtRlhkMWtrYTVyX0dWbjhXRkl4VTBIbHZoR1lPZjJUS0FmcEF6bn

Les secrets de la mémoire presque révélés ! - Midi Libre

📰 Midi Libre · 23/04/2019

<a href="https://news.google.com/rss/articles/CBMikwFBVV95cUxOczJEVy14REcyVTR6bVlXbTZXM1lKX0FTMWl1N2pQcVRaSWpkZDI5bkJRT3VXLTR6X01OVWhRbmtuVUtOdEwtY3BjSWxMY3BxNUJPa3NIOUpMeVJOWENLZXpoX20wYUljTlMwM0gzUUgzalkta2l6WWJScThzclJBVDFiNFhPbXE5NnFKSzdVUkhncTg?oc=5" target="_blank">Les secrets de la mémoire pr

Top publications · les plus citées

Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study

Brain : a journal of neurology · 2019

📚 833 citations🎯 RCR 50.53Top 0% NIH🩺 Clinique🔓 Open Access📄 PDF gratuit ↗

A single-question screen for rapid eye movement sleep behavior disorder: a multicenter validation study

Movement disorders : official journal of the Movement Disorder Society · 2012

📚 338 citations🎯 RCR 12.81Top 2% NIH

Lire l'abstract Crossref ↓

AbstractBackground:Idiopathic rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia that is an important risk factor for Parkinson's disease (PD) and Lewy body dementia. Its prevalence is unknown. One barrier to determining prevalence is that current screening tools are too long for large‐scale epidemiologic surveys. Therefore, we designed the REM Sleep Behavior Disorder Single‐Question Screen (RBD1Q), a screening question for dream enactment with a simple yes/no response.Methods:Four hundred and eighty‐four sleep‐clinic–based participants (242 idiopathic RBD patients and 242 controls) completed the screen during a multicenter case‐control study. All participants underwent a polysomnogram to define gold‐standard diagnosis according to standard criteria.Results:We found a sensitivity of 93.8% and a specificity of 87.2%. Sensitivity and specificity were similar in healthy volunteers, compared to controls or patients with other sleep diagnoses.Conclusions:A single‐question screen for RBD may reliably detect disease, with psychometric properties favorably comparable to those reported for longer questionnaires. © 2012 Movement Disorder Society

Progression of clinical markers in prodromal Parkinson's disease and dementia with Lewy bodies: a multicentre study

Brain : a journal of neurology · 2023

📚 97 citations🎯 RCR 17.11Top 1% NIH🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

Abstract The neurodegenerative synucleinopathies, including Parkinson’s disease and dementia with Lewy bodies, are characterized by a typically lengthy prodromal period of progressive subclinical motor and non-motor manifestations. Among these, idiopathic REM sleep behaviour disorder is a powerful early predictor of eventual phenoconversion, and therefore represents a critical opportunity to intervene with neuroprotective therapy. To inform the design of randomized trials, it is essential to study the natural progression of clinical markers during the prodromal stages of disease in order to establish optimal clinical end points. In this study, we combined prospective follow-up data from 28 centres of the International REM Sleep Behavior Disorder Study Group representing 12 countries. Polysomnogram-confirmed REM sleep behaviour disorder subjects were assessed for prodromal Parkinson’s disease using the Movement Disorder Society criteria and underwent periodic structured sleep, motor, cognitive, autonomic and olfactory testing. We used linear mixed-effect modelling to estimate annual rates of clinical marker progression stratified by disease subtype, including prodromal Parkinson’s disease and prodromal dementia with Lewy bodies. In addition, we calculated sample size requirements to demonstrate slowing of progression under different anticipated treatment effects. Overall, 1160 subjects were followed over an average of 3.3 ± 2.2 years. Among clinical variables assessed continuously, motor variables tended to progress faster and required the lowest sample sizes, ranging from 151 to 560 per group (at 50% drug efficacy and 2-year follow-up). By contrast, cognitive, olfactory and autonomic variables showed modest progression with higher variability, resulting in high sample sizes. The most efficient design was a time-to-event analysis using combined milestones of motor and cognitive decline, estimating 117 per group at 50% drug efficacy and 2-year trial duration. Finally, while phenoconverters showed overall greater progression than non-converters in motor, olfactory, cognitive and certain autonomic markers, the only robust difference in progression between Parkinson’s disease and dementia with Lewy bodies phenoconverters was in cognitive testing. This large multicentre study demonstrates the evolution of motor and non-motor manifestations in prodromal synucleinopathy. These findings provide optimized clinical end points and sample size estimates to inform future neuroprotective trials.

Cookies & analyse de trafic

MME Valerie COCHEN-DE COCK

Pourquoi vous devez consulter ce praticien

Activité de recherche & publications

Publications académiques en France

Lieux de consultation(2)

Tarifs & secteur de conventionnement

Prendre rendez-vous & contact

Articles de presse (5)

Top publications · les plus citées

Publications scientifiques (45) — classées par pathologie

Santé mentale / fatigue34

Transversal9

Génétique4

Biomarqueurs / Auto-Ac1

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