M MICHEL CLOT

Rhumatologue

RPPS 10001296358

📊 Reconnaissance scientifique : 3/100📝 21 articles publiés

✨ Génération du profil synthétique IA en cours…

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3 articles ont été cités au moins 3fois par d'autres chercheurs — preuve que ses travaux sont repris par la communauté médicale.

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Top publications · les plus citées

Involvement of the mural thrombus as a site of protease release and activation in human aortic aneurysms

The American journal of pathology · 2002

📚 271 citations🎯 RCR 6.54Top 5% NIH🔓 Open Access📄 PDF gratuit ↗

Differential inflammatory activity across human abdominal aortic aneurysms reveals neutrophil-derived leukotriene B4 as a major chemotactic factor released from the intraluminal thrombus

FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009

📚 95 citations🎯 RCR 2.59Top 20% NIH🔓 Open Access📄 PDF gratuit ↗

Lire l'abstract Crossref ↓

Development and progression of acquired abdominal aortic aneurysms (AAAs) have been associated with different inflammatory mediators. The aim of the present study was to elucidate the topology and the potential mechanisms linking the leukotriene pathway to human AAAs. Human aneurysmal lesions were obtained from 24 patients undergoing surgery, and the intraluminal thrombus was separated from the vascular wall. Histological examination revealed major expression of the leukotriene‐producing enzymes 5‐lipoxygenase and LTA 4 hydrolase, as well as the two receptors for leukotriene B 4 (BLT1R and BLT2R), corresponding to neutrophils in the luminal part of the thrombus. In contrast, in the vascular wall, the leukotriene pathway mainly localized in macrophage‐rich adventitial areas. Furthermore, conditioned media of the intraluminal thrombus contained significantly higher concentrations of leukotriene B 4 than that derived from the vascular wall, which were significantly correlated to other neutrophil‐derived mediators, such as elastase/a 1 ‐antitrypsin complexes, myeloperoxidase, and MMP9/NGAL complexes. Finally, the neutrophil‐chemotactic activity of the conditioned media from the intraluminal thrombus exhibited major inhibition by antagonists of the leukotriene B 4 receptors. Taken together, these results indicate neutrophil‐derived leukotriene B 4 as a major neutrophil chemotactic factor released from the intraluminal thrombus of human AAAs and suggest that targeting BLT receptors may represent a potential medical therapeutic strategy in the prevention of AAA progression in humans.— Houard, X., Ollivier, V., Louedec, L., Michel, J.‐B., Back, M. Differential inflammatory activity across human abdominal aortic aneurysms reveals neutrophil‐derived leukotriene B4 as a major chemotactic factor released from the intraluminal thrombus. FASEBJ. 23, 1376–1383 (2009)

Lymphocyte subpopulations in bronchoalveolar lavages of patients with sarcoidosis and hypersensitivity pneumonitis

Chest · 1981

📚 62 citations🎯 RCR 2.93Top 17% NIH

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Publications scientifiques (31) — classées par pathologie

Transversal25

Épidémiologie & registres3

Fièvres auto-inflammatoires1

Pharmacovigilance1

Revue générale1

Vraie vie / RWE1

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