📇 Rhumatologue · LONGJUMEAU · (91) · Salarié

MME Cécile CELLIER

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Auteur de référence en rhumatologie
20 articles scientifiques publiés — un praticien à la pointe de la recherche
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Rhumatologue

📍 LONGJUMEAU (91)SalariéRPPS 10001421659

🇫🇷 Publications académiques françaises (1)

✨ Génération du profil synthétique IA en cours…

Publications académiques en France

Articles déposés en accès libre sur l'archive ouverte des universités françaises (HAL) — gage d'activité de recherche en France.

Does ATRX germline variation predispose to osteosarcoma? Three additional cases of osteosarcoma in two ATR-X syndrome patients
2018
Article

Données ANS publiques (Licence Ouverte 2.0) · Enrichissements MonRhumato 100 % opt-in · Toute personne référencée peut demander la suppression ou la rectification.

Top publications · les plus citées

Long-term follow-up of 61 coeliac patients diagnosed in childhood: evolution toward latency is possible on a normal diet

Gut · 2007

📚 104 citations🎯 RCR 3.03Top 16% NIH🔓 Open Access📄 PDF gratuit ↗

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Background/Aims: Whether a life-long gluten-free diet (GFD) is necessary in all children with diagnosed coeliac disease (CD) remains debated. To address this question, a retrospective analysis of the clinical and biological status of adult coeliac patients diagnosed in childhood, who remained on a normal diet after gluten challenge and were clinically silent, was carried out. Methods: Patients aged 18–65 years with CD diagnosed in childhood were included. Clinical status, gluten intake, biological parameters of malabsorption, bone mineral density, human leucocyte antigen (HLA) genotype, serological markers of CD, and histological and immunohistochemical parameters in duodenal biopsies were recorded. Results: Sixty-one patients had resumed a normal diet and were asymptomatic. Forty-eight showed different degrees of villous atrophy (silent CD), while 13 had no detectable atrophy (latent CD) on duodenal biopsies. Latent CD patients had significantly less osteopenia/osteoporosis (1/9 (11%) vs 23/33 (70%), p<0.001)), and lower T cell receptor (TCR) αβ+ intraepithelial T cell counts (38±20 vs 55±15, p<0.01) than silent CD patients. The mean age at diagnosis and first GFD was lower in latent than in silent patients (14.4±5 vs 40.1±47 months, p<0.05). Latent patients did not differ significantly from the seven control patients on a long-term GFD, except for a higher frequency of CD-specific serum antibodies. However, two latent patients relapsed clinically and histologically during subsequent follow-up. Conclusions: Long-term latency developed in about 20% of CD patients who remained symptom free after gluten reintroduction. This latency can be transient and thus a regular follow-up is mandatory. In silent patients, the increased risk of osteoporosis substantiates the need for a GFD.

Ewing-like sarcomas with BCOR-CCNB3 fusion transcript: a clinical, radiological and pathological retrospective study from the Société Française des Cancers de L'Enfant

Pediatric blood & cancer · 2014

📚 97 citations🎯 RCR 3.56Top 13% NIH

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BackgroundThis retrospective multicenter study assessed the clinical, radiological and pathological presentation, treatment and outcome of 26 patients with Ewing‐like sarcoma harboring BCOR‐CCNB3 gene fusion transcript. Tumor samples had been collected between 1994 and April 2012.ProcedureEligibility criteria included assessment of a BCOR‐CCNB3 transcript‐positive tumor after molecular analysis and availability of minimal clinical and pathological data. Radiological data were also retrieved when possible. Data were analyzed by descriptive statistics and methods for survival analysis.ResultsMedian age at diagnosis was 13.1 years (5.9 to 25.6 years). Most patients (24/26) had localized tumors. All tumors but five were localized to bone. CCNB3 immunochemistry showed strong nuclear staining on all samples. No specific radiological features were found. Most patients received chemotherapy (15 according to protocols designed for Ewing tumors), before and/or after local treatment (surgery and/or radiotherapy, with 46.2% receiving both). Local and metastatic relapses were of poor prognosis. Induction chemotherapy and treatment according to an Ewing protocol might influence survival for patients with localized tumors. Sixteen patients are alive in complete remission with a median follow‐up of 86 months. Five year overall survival and disease‐free survival were respectively 76.5% (95% CI, 58%–95%) and 67.9% (95% CI, 48%–88%).ConclusionsBCOR‐CCNB3 transcript‐positive Ewing‐like sarcoma diagnosis should be discussed for a transcript‐negative small round cell sarcoma in a child, adolescent or young adult patient. Diagnosis needs to be stated through CCNB3 immunochemistry or transcript identification. The exquisite chemosensitivity of these tumors should encourage the use of polychemotherapy for appropriate care, associated with best local tumor control. Pediatr Blood Cancer 2014;61:2191–2198. © 2014 Wiley Periodicals, Inc.

Celiac Disease-Related Conditions: Who to Test?

Gastroenterology · 2024

📚 46 citations🎯 RCR 13.85Top 1% NIH🔓 Open Access📄 PDF gratuit ↗

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MME Cécile CELLIER

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Publications académiques en France

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Publications scientifiques (20) — classées par pathologie

Pédiatrie10

Transversal9

Économie santé1

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